Leukotoxin-activated human pulmonary artery endothelial cell produces nitric oxide and superoxide anion

Pulmonary Pharmacology and Therapeutics

Volumn 15, Issue 1, 2002, Pages 25-33

  Okamura, Seitaro ^a   Ameshima, Shingo ^a   Demura, Yoshiki ^a   Ishizaki, Takeshi ^a   Matsukawa, Shigeru ^a   Miyamori, Isamu ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

Endothelial nitric oxide synthase (eNOS); Human pulmonary artery endothelial cells; Leukotoxin (Lx); Nitric oxide; Superoxide anion

Indexed keywords

ALLOPURINOL; ARGININE; CALCIUM ION; CITRULLINE; ETHIDIUM BROMIDE; LEUKOTOXIN; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGEN; SUPEROXIDE; XANTHINE OXIDASE INHIBITOR;

ANALYZER; ARTERY ENDOTHELIUM; ARTICLE; CELL ACTIVATION; CELL SUSPENSION; CHEMOLUMINESCENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; OXIDATION; PRIORITY JOURNAL; PULMONARY ARTERY; SPECTROFLUOROMETRY; SPECTROPHOTOMETER;

EID: 0036354862     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1006/pupt.2001.0322     Document Type: Article

References (34)

1. Hydroxyl radical and leukotoxin biosynthesis in neutrophil plasma membrane
2. Existence of leukotoxin 9, 10-epoxy-12-octadecenoate in lung lavages from rats breathing pure oxygen and from patients with the adult respiratory distress syndrome
3. Neutrophil-derived epoxide, 9, 10-epoxy-12-octadecenoate, induces pulmonary edema
4. Leukotoxin, 9, 10-epoxy-12-octadecenoate inhibits mitochondrial respiration of isolated perfused rat lung
5. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
6. Evidence for in vivo peroxynitrite production in human acute lung injury
7. Xanthine oxidase mediates elastase-induced injury to isolated lungs and endothelium
8. Pulmonary endothelial cell killing by human neutrophils: Possible involvement of hydroxyl radicals
9. Mechanisms of endothelial cell killing by H2O2 or products of activated neutrophils
10. Production of nitric oxide and peroxynitrite in the lung during acute endotoxemia
11. Leukotoxin, 9, 10-epoxy-12-octadecenoate causes edematous lung injury via activation of vascular nitric oxide synthase
12. Role of nitric oxide and superoxide anion in leukotoxin-, 9, 10-epoxy-12-octadecenoate-induced mitochondrial dysfunction
13. Leukotoxin, 9, 10-epoxy-12-octadecenoate causes pulmonary vasodilation in rats
14. Leukotoxin, 9, 10-epoxy-12-octadecenoate causes pulmonary vasodilation via stimulation of vascular eNOS and iNOS
15. Response of cultured human pulmonary artery endothelial cells to endotoxin
16. Nitric oxide synthesis in endothelial cells: Evidence for a pathway inducible by TNF-alpha
17. The activation of eNOS by copper ion (Cu2+) in human pulmonary arterial endothelial cells (HPAEC)
18. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum
19. Increased nitric oxide biosynthesis in leukotoxin, 9,10-epoxy-12-octadecenoate injured lung
20. Regulation of nitric oxide synthesis by oxygen in vascular endothelial cells
21. Measurement of intracellular fluorescence of human monocytes reactive to oxidative metabolism
22. Flow cytometric analysis of respiratory burst activity in phagocytes with hydroethidine and 2′, 7′-dichlorofluorescin
23. Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells
24. Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical
25. Peroxynitrite inhibits inducible (Type2) nitric oxide synthase in murine lung epithelial cells in vitro
26. Are leukotoxins toxic?
27. Leukotoxins and the lung
28. Linoleic acid and TNF-alpha cross-amplify oxidative injury and dysfunction of endothelial cells
29. Linoleic acid potentiates TNF-mediated oxidative stress, disruption of ancium homeostasis, and apoptosis of cultured vascular endothelial cells
30. ARDS and Leukotoxin
31. Bioactivation of leukotoxin to their toxic diols by epoxide hydrolase
32. Leukotoxin and its diol induce neutrophil chemotaxis through signal transudation different from that of fMLP
33. Regulation of endothelial nitric oxide synthase gene expression by oxidized linoleic acid
34. The role of endothelial cells in the relaxations induced by 13-hydroxy-and 13-hydroperoxylinoleic acid in canine arteries