Leukotoxin, 9,10-epoxy-12-octadecenoate, causes pulmonary vasodilation by stimulation of vascular eNOS and iNOS

Lung

Volumn 178, Issue 3, 2000, Pages 137-148

  Nakanishi, M ^a   Ishizaki, T ^a   Demura, Y ^a   Okamura, S ^a   Ameshima, S ^a   Sasaki, F ^a   Matsukawa, S ^a   Miyamori, I ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

CyclicGMP; Human pulmonary artery smooth muscle cell (HPASMC); Leukotoxin; NOS inhibitor; Rat pulmonary artery

Indexed keywords

AMINOGUANIDINE; CYCLIC GMP; LEUKOTOXIN; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; LUNG BLOOD VESSEL; LUNG INJURY; LUNG LAVAGE; LUNG VASOCONSTRICTION; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; RAT; SMOOTH MUSCLE FIBER; VASCULAR ENDOTHELIUM;

EID: 0033930218     PISSN: 03412040     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00408000000017     Document Type: Article

References (24)

1. Ameshima S, Ishizaki T, Demura Y, Matsukawa S, Sasaki F, Nakai T, Hayakawa M, Ozawa T (1997) Production of Superoxide anion and cell injury induced in human pulmonary artery endothelial cells by Leukotoxin. Am J Respir Crit Care Med 155:A241
2. Garland CJ, Plane F, Kemp BK, Cocks TM (1995) Endothelium dependent hyperpolarization: a role in the control of vascular tone. Trends Pharmacol Sc 16:23-30
3. Griffiths MJD, Liu S, Curzen NP, Messent M, Evans TW (1995) In vivo treatment with endotoxin induces nitric oxide synthase in rat main pulmonary artery. Am J Physiol 268 (Lung Cell Mol Physiol):L509-518
4. Griffiths MJD, Messent M, MacAllister RJ, Evans TW (1993) Aminoguanidine selectively inhibits inducible nitric oxide synthase. Br J Pharmacol 110:963-968
5. Hayakawa M, Sugiyama S, Takamura T, Yokoo K, Iwata M, Suzuki K, Taki F, Takahashi S, Ozawa T (1986) Neutrophils biosynthesize leukotoxin, 9,10-epoxy-12-octadecenate. Biochem Biophys Res Commun 137:424-430
6. Ishizaki T, Ozawa T, Voelkel NF (1999) Leukotoxins and the lung. Pulm Pharmacol Ther 12:145-155
7. Ishizaki T, Shigemori K, Nakai T, Miyabo S, Ozawa T, Chang S, Voelkel NF (1995) Leukotoxin, 9, 10-epoxy-12-octadecenoate, causes edematous lung injury via activation of vascular nitric oxide synthase. Am J Physiol 269 (Lung Cell Mol Physiol 13):L65-L70
8. Ishizaki T, Shigemori K, Yamamura Y, Matsukawa S, Nakai T, Miyabo S, Hayakawa M, Ozawa T, Voelkel NF (1995) Increased nitric oxide biosynthesis in leukotoxin, 9-10-epoxy-12-octadecenate, injured lung. Biochem Biophys Res Commun 210:133-137
9. Ishizaki T, Takahashi H, Ozawa T, Shin-Wen Chang, Voelkel NF (1995) Leukotoxin, 9,10-epoxy-12-octadecenate causes pulmonary vasodilation in rats. Am J Physiol 268 (Lung Cell Mol Physiol 12):L123-L128
10. Jia-ning H, Taki F, Sugiyama S, Asai J, Izawa Y, Satake T, Ozawa T (1988) Neutrophil-derived epoxide, 9-10-Epoxy-12-octadecenoate, induces pulmonary edema. Lung 166:327-337
11. Jourdan KB, Evans TW, Lamb NJ, Goldstraw P, Mitchell JA (1999) Autocrine function of inducible nitric oxide synthase and cyclooxygenase-2 in proliferation of human and rat pulmonary artery smooth-muscle cells. Species variation. Am J Respir Cell Mol Biol 21:105-110
12. Liu S, Adcock IM, Robert WO, Barnes PJ, Evans TW (1993) Lipopolysaccharide treatment in vivo induces widespread tissue expression of inducible nitric oxide synthase mRNA+. Biochem Biophys Res Commun 196:1208-1213
13. Liu S, Crawley D, Barnes P, Evans T (1991) Endothelium-derived relaxing factor inhibits hypoxic pulmonary vasoconstriction in rats. Am Rev Respir Dis 143:32-37
14. Melot C, Lejeune P, Leeman M, Moraine JJ, Naeije R (1989) Prostaglandin E1 in adult respiratory distress syndrome. Benefit for pulmonary hypertension and cost for pulmonary gas exchange. Am Rev Respir Dis 139:106-110
15. Nakayama DK, David AG, Lowenstein CJ, Davies P, Pitt BR, Simmons RL, Billiar TR (1992) Cytokines and lipopolysaccharide induce nitric oxide synthase in cultured rat pulmonary artery smooth muscle. Am J Respir Cell Mol Biol 7:471-476
16. Okamura S, Ishizaki T, Demura Y, Ameshima S, Sasaki F, Miyamori I, Matsukawa S (1998) Leukotoxin, 9,10-epoxy-12-octadecenate increases nitric oxide production caused by activation of nitric oxide synthase in cultured human pulmonary artery endothelial cells. Am J Respir Crit Care Med 157:A229
17. Ozawa T, Hayakawa M, Takamura T, Sugiyama S, Suzuki K, Iwata M, Taki F, Tomita T (1998) Biosynthesis of leukotoxin, 9-10-epoxy-12-octadecenate, by leukocytes in lung lavages of rat after exposure to hyperoxia. Biochem Biophys Res Commun 134:1071-1078
18. Ozawa T, Sugiyama S, Hayakawa M, Satake T, Taki F, Iwata M, Taki K (1988) Existence of leukotoxin, 9,10-epoxy-12-octadecenoate in lung lavages from rats breathing pure oxygen and from patients with the adult respiratory distress syndrome. Am Rev Respir Dis 137:535-540
19. Ozawa T, Sugiyama S, Hayakawa M, Taki T (1991) ARDS and Leukotoxin. Jpn J Thorac Dis 29:159-164
20. Ozawa T, Sugiyama S, Hayakawa M, Taki F, Hanaki Y (1988) Neutrophil microsomes biosynthesize linoleate epoxide (9,10-epoxy-12-octadecenoate), a biological active substance. Biochem Biophys Res Commun 152:1310-1318
21. Palmer RMJ, Ferrige AG, Moncada S (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327:524-526
22. Walmarath D, Schneider T, Pilch J, Grimminger F, Seeger W (1993) Aerosolized prostacyclin in adult respiratory distress syndrome. Lancet 342:961-962
23. Wang R, Wang Z, Wu L (1997) Carbon monoxide-induced vasorelaxation and the underlying mechanisms. Br J Pharmacol 121:927-934
24. Zimmerman GA, Renzetti AD, Hill HR (1983) Functional and metabolic activity of granulocytes from patients with adult respiratory distress syndrome. Evidence for activated neutrophils in pulmonary circulation. Am Rev Respir Dis 127:290-300