Cocaethylene's effects on coronary artery blood flow and cardiac function in a canine model

Journal of Toxicology - Clinical Toxicology

Volumn 40, Issue 5, 2002, Pages 535-546

  Wilson, Lance D ^a   French, Scott ^a  

^a METROHEALTH MEDICAL CENTER   (United States)

Author keywords

Arrhythmias; Cardiac conduction; Cocaethylene; Coronary blood flow; Myocardial function

Indexed keywords

ALCOHOL; COCAINE; HOMOCOCAINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DOG; DOPPLER FLOWMETRY; DRUG EFFECT; HEART ARRHYTHMIA; HEART CONDUCTION; HEART FUNCTION; HYPERTENSION; NEUROTRANSMITTER RELEASE; NONHUMAN; SYSTEMIC VASCULAR RESISTANCE; TRANSESTERIFICATION;

ANIMALS; COCAINE; CORONARY CIRCULATION; DOGS; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; HEART; HEMODYNAMIC PROCESSES; INFUSIONS, INTRAVENOUS;

ANIMALIA; CANIS FAMILIARIS; CYGNUS; PISUM SATIVUM;

EID: 0036354553     PISSN: 07313810     EISSN: None     Source Type: Journal    
DOI: 10.1081/CLT-120014642     Document Type: Article

References (60)

1. Concurrent and Simultaneous Use of Alcohol and Cocaine: Results of a National Survey
2. Cardiac arrhythmia and myocardial ischemia related to cocaine and alcohol consumption
3. Cocaethylene: A unique cocaine metabolite displays high affinity for the dopamine transporter
4. Sudden death from acute cocaine intoxication in Virginian 1988
5. An accidental death related to cocaine, cocaethylene, and caffeine
6. Cocaine, alcohol mix in body to form even longer lasting, more lethal drug
7. Cocaine plus alcohol is more cardiotoxic than cocaine or alcohol alone
8. Additive myocardial depressant effects of cocaine and ethanol
9. Alcohol and cocaine interaction in humans
10. Ethanol/cocaine interaction: Cocaine and cocaethylene plasma concentrations and their relationship to subjective and cardiovascular effects
11. Effects of ethanol and cocaethylene on cocaine pharmacokinetics in conscious dogs
12. Concurrent cocaine-ethanol ingestion in humans: Pharmacology, physiology, behavior, and the role of cocaethylene
13. Prospective multicenter evaluation of cocaine-associated chest pain
14. Cocaethylene: A neuropharmacologically active metabolite associated with concurrent cocaine-ethanol ingestion
15. Comparative behavioral pharmacology and toxicology of cocaine and its ethanol-derived metabolite, cocaine ethyl-ester, (Cocaethylene)
16. Effects of cocaine and ethylcocaine on schedule-controlled responding in rats
17. Cocaethylene is more potent than cocaine in mediating lethality
18. Plasma cocaethylene concentrations in patients treated in the emergency room or trauma unit
19. Cocaethylene: Pharmacologic activity and clinical significance
20. Cocaethylene causes dose-dependent reductions in cardiac function in anesthetized dogs
21. 2+ and myocardial contraction in cardiac myocytes
22. Direct cardiotoxic effects of cocaine and cocaethylene on isolated cardiomyocytes
23. Human liver esterases: Ethanol-mediated formation of ethylcocaine
24. Recurrent coronary vasoconstriction caused by intranasal cocaine: Possible role for metabolites
25. Effect of cocaine and cocaine metabolites on cerebral arteries in vitro
26. The effects of acute and chronic cocaine use on the heart
27. Cocaine-induced coronary artery vasoconstriction
28. Alpha-chloralose as a canine anesthetic
29. Left Ventricular Dynamics in Dogs During Anesthesia with Alpha-Chloralose and Sodium Pentobarbital
30. Accuracy and clinical utility of an oxygen saturation catheter
31. New technique for measurement of cardiac output by thermodilution in man
32. Comprehensive review of cocaethylene and cocaine concentrations in patients
33. Formation and elimination kinetics of cocaethylene in humans
34. Analysis of cocaine and cocaethylene in blood and tissues by GCNPD and GC-ion trap mass spectrometry
35. Site-dependent postmortem changes in blood cocaine concentrations
36. Cocaethylene: Pharmacological, physiological, and behavioral effects in humans
37. Comparison in humans of the potence and pharmacokinetics of IV injected cocaethylene and cocaine
38. Alcohol plus cocaine: The whole is more than the sum of its parts
39. Relating cocaine blood concentration to toxicity-an autopsy study of 99 cases
40. Brain concentrations of cocaine and benzoylecognine in fatal cases
41. Tolerance develops to the sympathomimetic but not the local anesthetic effects of cocaine
42. Cocaethylene toxicity in rat primary myocardial cell cultures
43. Cocaethylene, a metabolite of cocaine and ethanol, is a potent blocker of cardiac sodium channels
44. Characterization of the sodium channel blocking properties of the major metabolites of cocaine in single cardiac myocytes
45. Inhibition by cocaine of excitation-contraction coupling in isolated cardiomyocytes
46. Cocaine, ethanol, and cocaethylene cardiotoxicity in an animal model of cocaine and ethanol abuse
47. Electrophysiologic in vitro effects of cocaine and its metabolites
48. Early repolarizations and triggered activity induced by cocaine: A possible mechanism of cocaine arrhythmogenesis
49. Direct actions of cocaine on cardiac cellular electrical activity
50. Reversal of the electrocardiographic effects of cocaine by lidocaine. Part 2. Concentration-effect relationships
51. Cocaine and sudden 'Natural' death
52. Cocaine and cardiovascular function in dogs: Effects on heart and peripheral circulation
53. Mechanism of cocaine-induced myocardial depression in dogs
54. Cocaine and its metabolites constrict cerebral arterioles in newborn pigs
55. Hemodynamic and cerebral blood flow effects of cocaine, cocaethylene and benzoylecognine in conscious and anesthetized fetal lambs
56. Influence of cocaine, ethanol, or their combination on epicardial coronary arterial dimensions in humans
57. Cocaine-induced microvascular spasm in yucatan miniature swine: In vivo and in vitro evidence of spasm