Evaluation of interaction potential of certain concurrently administered drugs with pharmacological and pharmacokinetic profile of centchroman in rats

Contraception

Volumn 66, Issue 1, 2002, Pages 47-56

  Khurana, M ^a   Lal, J ^a   Singh, M M ^a   Paliwal, J K ^a   Kamboj, V P ^a   Gupta, R C ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

7 desmethyl centchroman; Bile; Centchroman; Diazepam; Feces; Haloperidol; Ibuprofen; Interaction; Lactic acid bacillus spores; Nifedipine; Ormeloxifene; Paracetamol; Rifampicin; Salbutamol; Sporlac; Tetracycline

Indexed keywords

CENTCHROMAN; DIAZEPAM; DRUG METABOLITE; HALOPERIDOL; IBUPROFEN; NIFEDIPINE; PARACETAMOL; RIFAMPICIN; SALBUTAMOL; TETRACYCLINE;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL SPORE; BILE; CIRCULATION; COITUS; CONTRACEPTION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG EXCRETION; FECES; FEMALE; GENDER; LACTIC ACID BACTERIUM; MALE; NONHUMAN; RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; BILE; BIOLOGICAL AVAILABILITY; CENTCHROMAN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONTRACEPTIVES, POSTCOITAL, SYNTHETIC; DRUG INTERACTIONS; FECES; FEMALE; MALE; RATS; RATS, SPRAGUE-DAWLEY; TETRACYCLINES;

EID: 0036348954     PISSN: 00107824     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0010-7824(02)00318-9     Document Type: Article

References (59)

1. New synthesis of cis- and trans-3-phenyl-4-[4-(β-pyrolidinoethoxy) phenyl]-7-methoxy chromans
2. Antifertility agents. 12. Structure activity relationship of 3,4- diphenyl chromenes and chromans
3. Antifertility activity of 3-4-trans-2,2-dimethyl-3-phenyl-4-[4-(β-pyrolidinoethoxy)phenyl]-7- methoxychromans
4. Centchroman, a selective estrogen receptor modulator, as a contraceptive and for the management of hormone-related clinical disorders
5. Effect of centchroman on tubal transport and pre-implantation embryonic developments in rats
6. Fetal resorption in rats treated with an antiestrogen in relation to luteal phase nidatory estrogen secretion
7. Time related effects of a triphenylethylene antiestrogen on estrogen induced changes in uterine weight, estrogen receptors, and endometrial sensitivity in immature rats
8. Inhibition of progesterone induced development of giant mitochondria in uterine glandular epithelial cells by an antiestrogen in rat
9. Duration of anti-implantation action of a triphenylethylene antiestrogen centchroman in adult female rats
10. Correlation of pinopod development on uterine luminal epithelial surface with hormonal events and endometrial sensitivity in rat
11. Uterine estradiol and progesterone receptor concentration, activities of certain antioxidant enzymes and dehydrogenases and histoarchitecture in relation to time of secretion of nidatory estrogen and high endometrial sensitivity in rat
12. Uterine luminal epithelial alkaline phosphatase activity and pinopod development in relation to endometrial sensitivity in rat
13. Clinical evaluation of centchroman: A new oral contraceptive
14. Centchroman
15. Biological profile of centchroman: A new post-coital contraceptive
16. Centchroman: A nonsteroidal anticancer agent for advanced breast cancer. Phase II study
17. Interaction with anti-implantation and estrogen antagonistic activities of dl-ormeloxifene, a selective estrogen receptor modulator, by tetracycline in female Sprague-Dawley rats
18. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man
19. Local absorption kinetics into the portal system using the portal venous concentration difference after an oral dose of diclofenac in the awakening rat
20. Simultaneous liquid chromatographic determination of centchroman and its 7-demethylated metabolite in serum and milk
21. Tissue distribution and pharmacokinetics of centchroman, a new nonsteroidal post-coital contraceptive agent and its 7-desmethyl metabolite in female rats after a single oral dose
22. The influence of variable gastric emptying and intestinal ransit rates on the plasma level curve of cimetidine: An explanation of the double peak phenomenon
23. Ranitidine bioavailability and kinetics in normal male subjects
24. Pharmacokinetics of furosemide in man after intravenous and oral administration: Application of moment analysis
25. Penicillamine pharmacokinetics in normal subjects
26. Pharmacokinetics and multiple peaking of acebutolol enantiomers in rats
27. A double peak phenomenon in the pharmacokinetics of veralipride after oral administration: A double-site model for drug absorption
28. A double peak phenomenon in the pharmacokinetics of alprazolam after oral administration
29. Discontinuous oral absorption of cimetroprium bromide, a new antispasmodic drug
30. Pharmacokinetics and bioavailability of cimetidine in humans
31. Pharmacokinetic analysis by linear system approach. I: Cimetidine bioavailability and second peak phenomenon
32. Biopharmaceutics
33. Further studies using carbamate esters as model compounds to investigate the role of lipophilicity in the gastrointestinal absorption of foreign compounds
34. Centchroman: Tissue distribution and excretion profile in albino rats after oral and intravenous administration
35. Physiological parameters in laboratory animals and humans
36. Effect of caffeine on ibuprofen-induced gastric mucosal damage in rats
37. Nonsteroidal anti-inflammatory drugs: How do they damage gastroduodenal mucosa
38. A tuberculosis survey based on symptoms questioning and sputum examination
39. Pharmacokinetic drug interactions with rifampicin
40. Rifampicin drastically reduces plasma concentration and effect of oral midazolam
41. Rifampicin drug interactions
42. Rifampin, oral contraceptives, and pregnancy
43. Effect of rifampicin on norethistrone pharmacokinetics
44. The effect of rifampicin on the pharmacokinetics of ethynylestradiol in women
45. Enzyme induction and inhibition
46. Clinically important pharmacokinetic drug-drug interactions: Role of cytochrome P450 enzymes
47. Centchroman: In vitro metabolism by rat liver homogenate
48. Antifertility agents. 38. Effect of side chain and its position on the activity of 3,4-diarylchromans
49. Inducing properties of rifampicin and rifabutin for selected enzyme activities of the cytochrome P-450 and UDP-glucuronosyltransferase superfamilies in female rat liver
50. Role of pharmacokinetics and metabolism in drug discovery and development
51. Hepatic drug metabolism enzyme induction and serum triacylglycerol elevation in rats treated with chlordiazepoxide, griseofulvin, rifampicin, and phenytoin
52. Influence of the combined chemotherapeutic drug tuboprim on drug metabolism
53. Haloperidol decanoate: A preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in psychosis
54. Interaction between broad-spectrum antibiotics and the combined oral contraceptive pill
55. Interactions between oral contraceptives and antifungals/antibacterials. Is contraceptive failure the result?