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Volumn 24, Issue 2, 1996, Pages 148-155

Tissue distribution and pharmacokinetics of centchroman: A new nonsteroidal postcoital contraceptive agent and its 7-desmethyl metabolite in female rats after a single oral dose

Author keywords

[No Author keywords available]

Indexed keywords

7 NORCENTCHROMAN; CENTCHROMAN; DRUG METABOLITE; POSTCOITUS CONTRACEPTIVE AGENT; UNCLASSIFIED DRUG;

EID: 0030029342     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (26)

References (39)
  • 1
    • 0000790950 scopus 로고
    • New synthesis of cis- And trans-3 phenyl-4-[4-(β-pyrolidinoethoxy)phenyl]-7-methoxychromans
    • S. Ray, P. K. Grover, and N. Anand: New synthesis of cis- and trans-3 phenyl-4-[4-(β-pyrolidinoethoxy)phenyl]-7-methoxychromans. Indian J. Chem. 9, 727-728 (1971).
    • (1971) Indian J. Chem. , vol.9 , pp. 727-728
    • Ray, S.1    Grover, P.K.2    Anand, N.3
  • 2
    • 0017236436 scopus 로고
    • Antifertility agents. 12. Structure-activity relationship of 3,4-diphenyl-chromenes and chromans
    • S. Ray, P. K. Grover, V. P. Kamboj, B. S. Setty, A. B. Kar, and N. Anand: Antifertility agents. 12. Structure-activity relationship of 3,4-diphenyl-chromenes and chromans. J. Med. Chem. 19, 276-279 (1976).
    • (1976) J. Med. Chem. , vol.19 , pp. 276-279
    • Ray, S.1    Grover, P.K.2    Kamboj, V.P.3    Setty, B.S.4    Kar, A.B.5    Anand, N.6
  • 3
    • 0000686316 scopus 로고
    • Antifertility activity of 3-4-trans-2,2-dimethyl-3-phenyl-4-[4-(β-pyrolidinoethoxy-)phenyl]-7- methoxychromans
    • V. P. Kamboj, A. B. Kar, S. Ray, P. K. Grover, and N. Anand: Antifertility activity of 3-4-trans-2,2-dimethyl-3-phenyl-4-[4-(β-pyrolidinoethoxy-)phenyl]-7- methoxychromans. Indian J. Exp. Biol. 9, 103-105 (1971).
    • (1971) Indian J. Exp. Biol. , vol.9 , pp. 103-105
    • Kamboj, V.P.1    Kar, A.B.2    Ray, S.3    Grover, P.K.4    Anand, N.5
  • 4
    • 0017240148 scopus 로고
    • Nature of estrogenic and anti-estrogenic actions of centchroman on rat uterus
    • S. Roy and J. K. Dutta: Nature of estrogenic and anti-estrogenic actions of centchroman on rat uterus. Contraception 13, 597-604 (1976).
    • (1976) Contraception , vol.13 , pp. 597-604
    • Roy, S.1    Dutta, J.K.2
  • 5
    • 0017565333 scopus 로고
    • Biological profile of centchroman - A new post-coital contraceptive
    • V. P. Kamboj, B. S. Setty, H. Chandra, S. K. Roy, and A. B. Kar: Biological profile of centchroman - a new post-coital contraceptive. Indian J. Exp. Biol. 15, 1141-1150 (1977).
    • (1977) Indian J. Exp. Biol. , vol.15 , pp. 1141-1150
    • Kamboj, V.P.1    Setty, B.S.2    Chandra, H.3    Roy, S.K.4    Kar, A.B.5
  • 6
    • 0016176805 scopus 로고
    • Antiestrogenicity of some nonsteroidal compounds
    • P. K. Mehrotra, J. N. Karkun, and A. B. Kar: Antiestrogenicity of some nonsteroidal compounds. Indian J. Exp. Biol. 12, 133-135 (1974).
    • (1974) Indian J. Exp. Biol. , vol.12 , pp. 133-135
    • Mehrotra, P.K.1    Karkun, J.N.2    Kar, A.B.3
  • 7
    • 0024337412 scopus 로고
    • Centchroman - A non-steroidal anticancer agent for advanced breast cancer. Phase II study
    • N. C. Misra, P. K. Nigam, R. Gupta, A. K. Agarwal, and V. P. Kamboj: Centchroman - a non-steroidal anticancer agent for advanced breast cancer. Phase II study. Int. J. Cancer 43, 781-783 (1989).
    • (1989) Int. J. Cancer , vol.43 , pp. 781-783
    • Misra, N.C.1    Nigam, P.K.2    Gupta, R.3    Agarwal, A.K.4    Kamboj, V.P.5
  • 9
    • 9044241070 scopus 로고    scopus 로고
    • Methods for reducing bone loss using centchroman derivatives. U.S. Patent 5280040. Zymogenetics, Inc., Seattle, WA
    • V. M. Labro, M. Creek, J. R. Piggott, Bothell, and S. D. Bain: Methods for reducing bone loss using centchroman derivatives. U.S. Patent 5280040. Zymogenetics, Inc., Seattle, WA.
    • Labro, V.M.1    Creek, M.2    Piggott, J.R.3    Bothell4    Bain, S.D.5
  • 10
    • 0019796653 scopus 로고
    • Effect of centchroman on preimplantation embryonic development and tubal transport in truce
    • M. M. Singh and V. P. Kamboj: Effect of centchroman on preimplantation embryonic development and tubal transport in truce. Biol. Reprod. 25, 171-180 (1981).
    • (1981) Biol. Reprod. , vol.25 , pp. 171-180
    • Singh, M.M.1    Kamboj, V.P.2
  • 11
    • 0002450420 scopus 로고
    • Clinical evaluation of centchroman: A new oral contraceptive
    • C. P. Puri and P. F. A. Van Look, eds.. Indian Society for the Studies on Reproduction and Fertility. Bombay. India
    • S. Nityanand, C. Wati, L. Singh, J. S. Srivastava, and V. P. Kamboj: Clinical evaluation of centchroman: a new oral contraceptive. In "Hormone Antagonists for Fertility Regulation" (C. P. Puri and P. F. A. Van Look, eds.). Indian Society for the Studies on Reproduction and Fertility. Bombay. India, 1988.
    • (1988) Hormone Antagonists for Fertility Regulation
    • Nityanand, S.1    Wati, C.2    Singh, L.3    Srivastava, J.S.4    Kamboj, V.P.5
  • 12
    • 0024789137 scopus 로고
    • High-performance liquid Chromatographic (HPLC) determination of centchroman in human serum and application to single-dose pharmacokinetics
    • J. K. Paliwal, R. C. Gupta, P. K. Grover, O. P. Asthana, J. S. Srivastava, and S. Nityanand: High-performance liquid Chromatographic (HPLC) determination of centchroman in human serum and application to single-dose pharmacokinetics. Pharm. Res. 6, 991-993 (1989).
    • (1989) Pharm. Res. , vol.6 , pp. 991-993
    • Paliwal, J.K.1    Gupta, R.C.2    Grover, P.K.3    Asthana, O.P.4    Srivastava, J.S.5    Nityanand, S.6
  • 13
    • 0028857057 scopus 로고
    • Pharmacokinetics of centchroman in healthy female subjects after oral administration
    • in press
    • J. Lal, O. P. Asthana, S. Nityanand, and R. C. Gupta: Pharmacokinetics of centchroman in healthy female subjects after oral administration. Contraception in press, 1995.
    • (1995) Contraception
    • Lal, J.1    Asthana, O.P.2    Nityanand, S.3    Gupta, R.C.4
  • 14
    • 0001929759 scopus 로고
    • Centchroman: Tissue distribution and excretion profile in albino rats after oral and intravenous administration
    • S. Ratna, N. Mishra, S. Ray, and S. K. Roy: Centchroman: tissue distribution and excretion profile in albino rats after oral and intravenous administration. J Basic Appl. Biomed. 2, 31-36 (1994).
    • (1994) J Basic Appl. Biomed. , vol.2 , pp. 31-36
    • Ratna, S.1    Mishra, N.2    Ray, S.3    Roy, S.K.4
  • 15
    • 0004061014 scopus 로고    scopus 로고
    • J. Swarbrick. ed., 2nd ed. Marcel Decker, Inc., New York
    • M. Gibaldi and D. Perrier: "Pharmacokinetics" (J. Swarbrick. ed.), 2nd ed. Marcel Decker, Inc., New York.
    • Pharmacokinetics
    • Gibaldi, M.1    Perrier, D.2
  • 16
    • 0025109566 scopus 로고
    • Analysis of drugs and other toxic substances in biological samples for pharmacokinetic studies
    • G. W. Peng and W. L. Chiou: Analysis of drugs and other toxic substances in biological samples for pharmacokinetic studies. J. Chromatogr. 531, 3-50 (1990).
    • (1990) J. Chromatogr. , vol.531 , pp. 3-50
    • Peng, G.W.1    Chiou, W.L.2
  • 17
    • 0019948955 scopus 로고
    • Universal multichannel ultraviolet detection in the purity analysis of 2-ethyl-3-(4-hydroxybenzoyl)indolizine by high-performance liquid chromatography
    • B. F. H. Drenth, R. T. Ghijsen, and R. A. Dezeeuw: Universal multichannel ultraviolet detection in the purity analysis of 2-ethyl-3-(4-hydroxybenzoyl)indolizine by high-performance liquid chromatography. J Chromatogr. 238, 113-120 (1982).
    • (1982) J Chromatogr. , vol.238 , pp. 113-120
    • Drenth, B.F.H.1    Ghijsen, R.T.2    Dezeeuw, R.A.3
  • 18
    • 0019967385 scopus 로고
    • Multichannel detection in high-performance liquid chromatography
    • J. C. Miller, S. A. George, and B. G. Willis: Multichannel detection in high-performance liquid chromatography. Science 218, 241-245 (1982).
    • (1982) Science , vol.218 , pp. 241-245
    • Miller, J.C.1    George, S.A.2    Willis, B.G.3
  • 19
    • 0020974382 scopus 로고
    • On-line screening for drug metabolites by high-performance liquid chromatography with a diode array detector
    • K. Zech, R. Huber, and H. Elgass: On-line screening for drug metabolites by high-performance liquid chromatography with a diode array detector. J. Chromatogr. 282, 161-167 (1983).
    • (1983) J. Chromatogr. , vol.282 , pp. 161-167
    • Zech, K.1    Huber, R.2    Elgass, H.3
  • 20
    • 9044248762 scopus 로고
    • Advances in multichannel photodiode-array based LC detection
    • T. Alfredson and T. Sheehan: Advances in multichannel photodiode-array based LC detection. Am. Lab. 17, 40-54 (1985).
    • (1985) Am. Lab. , vol.17 , pp. 40-54
    • Alfredson, T.1    Sheehan, T.2
  • 21
    • 0011779055 scopus 로고
    • Determination of compound identity by group type and class using diodearray detection in high-performance liquid chromatography
    • T. Alfredson, T. Sheehan, T. Lenert, S. Aamodt, and L. Correia: Determination of compound identity by group type and class using diodearray detection in high-performance liquid chromatography. J. Chromatogr. 385, 213-223 (1987).
    • (1987) J. Chromatogr. , vol.385 , pp. 213-223
    • Alfredson, T.1    Sheehan, T.2    Lenert, T.3    Aamodt, S.4    Correia, L.5
  • 23
    • 0001929759 scopus 로고
    • Centchroman: Tissue distribution and excretion profile in albino rats after oral and intravenous administration
    • S. Ratna, N. C. Mishra, S. Ray, and S. K. Roy: Centchroman: tissue distribution and excretion profile in albino rats after oral and intravenous administration. J. Basic Appl. Biomed. 2, 31-36 (1994).
    • (1994) J. Basic Appl. Biomed. , vol.2 , pp. 31-36
    • Ratna, S.1    Mishra, N.C.2    Ray, S.3    Roy, S.K.4
  • 24
    • 0015763703 scopus 로고
    • The metabolism of tamoxifen (I.C.I. 46,474). Part I. in laboratory animals
    • J. M. Fromson, S. Pearson, and S. Bramah: The metabolism of tamoxifen (I.C.I. 46,474). Part I. In laboratory animals. Xenobiotica 3, 693-709 (1973).
    • (1973) Xenobiotica , vol.3 , pp. 693-709
    • Fromson, J.M.1    Pearson, S.2    Bramah, S.3
  • 25
    • 0015748908 scopus 로고
    • The metabolism of tamoxifen (I.C.I. 46,474). Part II. in female patients
    • J. M. Fromson, S. Pearson, and S. Bramah: The metabolism of tamoxifen (I.C.I. 46,474). Part II. In female patients. Xenobiotica 3, 711-714 (1973).
    • (1973) Xenobiotica , vol.3 , pp. 711-714
    • Fromson, J.M.1    Pearson, S.2    Bramah, S.3
  • 26
    • 0025663351 scopus 로고
    • Preclinical studies with toremifene as an antitumor agent
    • S. P. Robinson, C. J. Parker, and V. C. Jordan: Preclinical studies with toremifene as an antitumor agent. Breast Cancer Res. Treat. 16 (Suppl.), S9-S17 (1990).
    • (1990) Breast Cancer Res. Treat. , vol.16 , Issue.SUPPL.
    • Robinson, S.P.1    Parker, C.J.2    Jordan, V.C.3
  • 27
    • 9044233073 scopus 로고
    • Properties of high affinity intracellular binding sites for antiestrogens
    • V. C. Jordan, ed., University of Wisconsin Press, Madison, WI
    • C. K. W. Watts, L. C. Murphy, and R. L. Sutherland: Properties of high affinity intracellular binding sites for antiestrogens. In "Estrogen/Antiestrogen Action and Breast Cancer Therapy" (V. C. Jordan, ed.), pp. 93-114. University of Wisconsin Press, Madison, WI, 1986.
    • (1986) Estrogen/Antiestrogen Action and Breast Cancer Therapy , pp. 93-114
    • Watts, C.K.W.1    Murphy, L.C.2    Sutherland, R.L.3
  • 28
    • 0020713776 scopus 로고
    • Antiestrogen-binding sites distinct from the estrogen receptor: Subcellular localization, ligand specificity, and distribution in tissues of the rat
    • K. Sudo, F. J. Monsma, and B. S. Katzenellenbogen: Antiestrogen-binding sites distinct from the estrogen receptor: subcellular localization, ligand specificity, and distribution in tissues of the rat. Endocrinology 112, 425-434 (1983).
    • (1983) Endocrinology , vol.112 , pp. 425-434
    • Sudo, K.1    Monsma, F.J.2    Katzenellenbogen, B.S.3
  • 29
    • 9044234198 scopus 로고
    • Antiestrogen binding to estrogen receptors and additional antiestrogen binding sites in human breast cancer cells
    • V. C. Jordan, ed., University of Wisconsin Press, Madison, WI
    • M. A. Miller, Y. Y. Sheen, A. Mullick, and B. S. Katzenellenbogen: Antiestrogen binding to estrogen receptors and additional antiestrogen binding sites in human breast cancer cells. In "Estrogen/Antiestrogen Action and Breast Cancer Therapy" (V. C. Jordan, ed.), pp. 127-148. University of Wisconsin Press, Madison, WI, 1986.
    • (1986) Estrogen/Antiestrogen Action and Breast Cancer Therapy , pp. 127-148
    • Miller, M.A.1    Sheen, Y.Y.2    Mullick, A.3    Katzenellenbogen, B.S.4
  • 30
    • 84911663683 scopus 로고
    • A possible basis for structure-function relationship of estrogens
    • S. Durrani and N. Anand: A possible basis for structure-function relationship of estrogens. Int. J. Quant. Chem. 20, 71-83 (1981).
    • (1981) Int. J. Quant. Chem. , vol.20 , pp. 71-83
    • Durrani, S.1    Anand, N.2
  • 31
    • 0020692891 scopus 로고
    • Antifertility agents 38: Effect of the side chain and its position on its activity of 3,4-diarylchromans
    • M. Salman, S. Ray, A. K. Agarwal, S. Durrani, B. S. Setty, V. P. Kamboj, and N. Anand: Antifertility agents 38: effect of the side chain and its position on its activity of 3,4-diarylchromans. J. Med. Chem. 26, 592-595 (1983).
    • (1983) J. Med. Chem. , vol.26 , pp. 592-595
    • Salman, M.1    Ray, S.2    Agarwal, A.K.3    Durrani, S.4    Setty, B.S.5    Kamboj, V.P.6    Anand, N.7
  • 32
    • 0018099203 scopus 로고
    • Receptors for androgen and estrogen in rat lung
    • W. K. Morishige and C. A. Uetake: Receptors for androgen and estrogen in rat lung. Endocrinology 102, 1827-1837 (1978).
    • (1978) Endocrinology , vol.102 , pp. 1827-1837
    • Morishige, W.K.1    Uetake, C.A.2
  • 34
    • 0020402019 scopus 로고
    • Metabolites of tamoxifen in animals and man: Identification, pharmacology, and significance
    • V. C. Jordan: Metabolites of tamoxifen in animals and man: identification, pharmacology, and significance. Breast Cancer Res. Treat. 2, 123-138 (1982).
    • (1982) Breast Cancer Res. Treat. , vol.2 , pp. 123-138
    • Jordan, V.C.1
  • 35
    • 0020120541 scopus 로고
    • 3H]monohydroxy tamoxifen by immature rat tissue in vivo
    • 3H]monohydroxy tamoxifen by immature rat tissue in vivo. Endocrinology 110, 1281-1291 (1982).
    • (1982) Endocrinology , vol.110 , pp. 1281-1291
    • Jordan, V.C.1    Browser-Finn, R.A.2
  • 36
    • 0020003085 scopus 로고
    • Tamoxifen and metabolite in MCF7 cells: Correlation between binding to estrogen receptor and inhibition of cell growth
    • E. Coezy, J. L. Borgna, and H. Rochefort. Tamoxifen and metabolite in MCF7 cells: correlation between binding to estrogen receptor and inhibition of cell growth. Cancer Res. 42, 317-323 (1982).
    • (1982) Cancer Res. , vol.42 , pp. 317-323
    • Coezy, E.1    Borgna, J.L.2    Rochefort, H.3
  • 37
    • 0025609120 scopus 로고
    • Introduction to toremifene
    • L. Kangas: Introduction to toremifene. Breast Cancer Res. Treat. 16 (Suppl.), S3-S7 (1990).
    • (1990) Breast Cancer Res. Treat. , vol.16 , Issue.SUPPL.
    • Kangas, L.1
  • 38
    • 0019411776 scopus 로고
    • Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues
    • J. L. Borgna and H. Rochefort: Hydroxylated metabolites of tamoxifen are formed in vivo and bound to estrogen receptor in target tissues. J. Biol. Chem. 256, 859-868 (1981).
    • (1981) J. Biol. Chem. , vol.256 , pp. 859-868
    • Borgna, J.L.1    Rochefort, H.2
  • 39
    • 0022335204 scopus 로고
    • Physiologic pharmacokinetic model for interanimal species scaling
    • M. Rowland: Physiologic pharmacokinetic model for interanimal species scaling. Pharmacol. Ther. 29, 49-69 (1985).
    • (1985) Pharmacol. Ther. , vol.29 , pp. 49-69
    • Rowland, M.1


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