Acute modulation of aged human memory by pharmacological manipulation of glucocorticoids

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 8, 2002, Pages 3798-3807

  Lupien, S J ^a   Wilkinson, C W ^b   Briere S ^c   Ng Ying Kin, N M K ^a   Meaney, M J ^b   Nair, N P V ^c  

^a MCGILL UNIVERSITY   (Canada)

^b CENTRE DE RECHERCHE   (Canada)

^c GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; HYDROCORTISONE; METYRAPONE;

AGED; AMNESIA; ARTICLE; CASE REPORT; COGNITION; CONTROLLED STUDY; HORMONE SUBSTITUTION; HUMAN; HYDROCORTISONE RELEASE; MEMORY; PRIORITY JOURNAL;

EID: 0036348292     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jcem.87.8.8760     Document Type: Article

References (56)

1. Hippocampal aging and adrenocorticoids: Quantitative correlations
2. Brain aging correlates: Retardation by hormonal-pharmacological treatments
3. The neuroendocrinology of stress and aging: The glucocorticoid cascade hypothesis
4. Stress hormones and brain aging
5. Basal cortisol levels and cognitive deficits in human aging
6. Increase in urinary cortisol excretion and memory declines: MacArthur studies of successful aging
7. Longitudinal study of basal cortisol levels in healthy elderly subjects: Evidence for subgroups
8. Longitudinal increase in cortisol during human aging predicts hippocampal atrophy and memory deficits
9. Selective loss of hippocampal granule cells in the mature rat brain after adrenalectomy
10. Adrenal steroid influences on the survival of hippocampal neurons
11. Restoring production of hippocampal neurons in old age
12. Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation
13. 5-Hydroxytryptamine and the mediation of pituitary-adrenocortical hormones in the extinction of active avoidance behavior
14. The acute effects of corticosteroids on cognition: Integration of animal and human model studies
15. Decreased memory performance in healthy humans induced by stress-level cortisol treatment
16. Acute cortisone administration impairs retrieval of long-term declarative memory in humans
17. Modulation of behavioral inhibition in appetitive extinction following manipulation of adrenal steroids in rats: Implications for involvement of the hippocampus
18. Glucocorticoids, the hippocampus, and behavior: Interactive relation between task activation and steroid hormone binding specificity
19. Effects of corticosterone on response consolidation and retrieval in the forced swim test
20. Adrenal steroids and extinction behavior: Antagonism by progesterone, deoxycorticosterone and dexamethasone of a specific effect of corticosterone
21. Glucocorticoids facilitate the retention of acquired immobility during forced swimming
22. Antiglucocorticoid RU 38486 attenuates retention of a behaviour and disinhibits the hypothalamic-pituitary adrenal axis at different brain sites
23. Decreased hypothalamic-pituitary-adrenal axis sensitivity to cortisol feedback inhibition in human aging
24. Relationships among cortisol (CRT), dehydroepiandrosterone-sulfate (DHEA-S), and memory in a longitudinal study of healthy elderly men and women
25. Development and validation of a geriatric depression screening scale: A preliminary report
26. Human glucocorticoid feedback inhibition is reduced in older individuals: Evening study
27. Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans
28. On methods in the analysis of profile data
29. Dose-dependent suppression of adrenocortical activity with metyrapone: Effects on emotion and memory
30. The modulatory effects of corticosteroids on cognition: Studies in young human populations
31. Abnormal cortisol response in Alzheimer's disease linked to hippocampal atrophy
32. Cortisol reduces hippocampal glucose metabolism in normal elderly, but not in Alzheimer's disease
33. The pathophysiologic significance of hyperadrenocorticism: Antiglucocorticoid strategies
34. Antiglucocorticoid therapies in major depression: A review
35. Antidepressant effects of treatments with metyrapone and hydrocortisone
36. Antidepressant effects of metyrapone
37. Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome
38. Decrease in cortisol reverses human hippocampal atrophy following treatment of Cushing's disease
39. Stress and cognition: Are corticosteroids good or bad guys?
40. Stress regulation of mineralocorticoid receptor heteronuclear RNA in rat hippocampus
41. Regulation of hippocampal glucocorticoid receptor gene transcription and protein expression in vivo
42. Regulation of serotonin 1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: Implications for the neurobiology of depression
43. Alpha, beta, and gamma mineralocorticoid receptor messenger ribonucleic acid splice variants: Differential expression and rapid regulation in the developing hippocampus
44. Glucocorticoid receptor mRNA in Alzheimer's disease hippocampus
45. Corticosterone, brain mineralocorticoid receptor (MRs) and the activity of the hypothalamic-pituitary-adrenal (HPA) axis: The Lewis rats as an example of increased central MR capacity and a hyporesponsive HPA axis
46. Modulatory actions of steroid hormones and neuropeptides on electrical activity in brain
47. Corticosteroid-mediated modulation of carbachol responsiveness in CA1 pyramidal neurons: A voltage clamp analysis
48. Modulation of 5HT1A responsiveness in CA1 pyramidal neurons by in vivo activation of corticosteroid receptors
49. Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems
50. Induction of anesthesia, seizures and sleep by steroid hormones
51. Steroid hormones are barbiturate-like modulators of the GABA receptor
52. Treatment of major depression with steroid suppressive drugs
53. Neuroendocrine developments in psychiatric research
54. The relationship between the effects of metyrapone treatment on depressed mood and urinary steroid profiles