The combination of ionizing radiation and expression of a wild type p53 gene via recombinant adenovirus induced a prominent tumour suppressing effect in human oral squamous cell carcinoma

British Journal of Radiology

Volumn 75, Issue 896, 2002, Pages 657-662

  Wakasa, T ^a   Inoue, T ^a   Kawai, N ^a   Murakami, J ^a   Kishi, K ^a   Fukui, K ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; PROTEIN P53;

ADENOVIRUS; ALLELE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL SURVIVAL; CLONOGENESIS; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; GENE EXPRESSION; GENE FUNCTION; GENE INDUCTION; GENE THERAPY; GENETIC CODE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IONIZING RADIATION; MOUTH CANCER; MUTANT; NONHUMAN; SQUAMOUS CELL CARCINOMA; VIRUS INFECTION; VIRUS RECOMBINANT; WESTERN BLOTTING; WILD TYPE;

EID: 0036342043     PISSN: 00071285     EISSN: None     Source Type: Journal    
DOI: 10.1259/bjr.75.896.750657     Document Type: Article

References (20)

1. Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus
2. In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma
3. Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck
4. Adenoviral-mediated wild-type p53 gene expression sensitizes colorectal cancer cells to ionizing radiation
5. Adenovirus-based transfer of wild-type p53 gene increases ovarian tumor radiosensitivity
6. Restoration of the G1 checkpoint and the apoptotic pathway mediated by wild-type p53 sensitizes squamous cell carcinoma of the head and neck to radiotherapy
7. The effects of combining ionizing radiation and adenoviral p53 therapy in nasopharyngeal carcinoma
8. Overexpression of p53 is an early event in the tumorigenesis of oral squamous cell carcinomas
9. High frequency of p53 alterations associated with protein overexpression in human squamous cell carcinoma of the larynx
10. Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome
11. High-efficiency transformation of mammalian cells by plasmid DNA
12. Adaptation of Karber's method for estimating the exponential parameter from quantal data, and its relationship to birth, death, and branching processes
13. Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers
14. Participation of p53 protein in the cellular response to DNA damage
15. Mutation in the p53 gene occur in diverse human tumour types
16. Wild-type p53 is a cell cycle checkpoint determinant following radiation
17. Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes
18. Screening the p53 status of human cell lines using a yeast functional assay
19. Dominant-negative p53 gene mutations selected in yeast hit cancer hot spots