Apoptosis Induction Mediated by Wild-Type p53 Adenoviral Gene Transfer in Squamous Cell Carcinoma of the Head and Neck

Cancer Research

Volumn 55, Issue 14, 1995, Pages 3117-3122

  Liu, Ta Jen ^a   El Naggar, Adel K ^a   McDonnell, Timothy J ^a   Steck, Kim D ^a   Wang, Mary ^a   Taylor, Dorothy L ^a   Clayman, Gary L ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER INHIBITION; DNA DEGRADATION; GENE EXPRESSION REGULATION; GENE THERAPY; GENE TRANSFER; GROWTH INHIBITION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

ADENOVIRIDAE; ANIMAL; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; DNA NUCLEOTIDYLEXOTRANSFERASE; DNA, NEOPLASM; DNA, VIRAL; FEMALE; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, P53; GENES, VIRAL; HEAD AND NECK NEOPLASMS; HUMAN; MICE; MICE, NUDE; MUTATION; NECROSIS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0029017333     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Linzer, D. I., and Levine, A. J. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell, 17: 43–52, 1979.
2. Lane, D. P., and Crawford, L. V. T antigen is bound to a host protein in SV40-transformed cells. Nature (Lond.), 278: 261–263, 1979.
3. Rodrigues, N. R., Rowan, A., Smith, M. E. F., Kerr, I. B., Bodmer, W. F., Gannon, J. V., and Lane, D. P. p53 mutations in colorectal cancer. Proc. Natl. Acad. Sci. USA, 87: 7555–7559, 1990.
4. Bartek, J., Iggo, R., Gannon, J., and Lane, D. P. Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines. Oncogene, 5: 893–899,1990.
5. Takahashi, T., Takahashi, T., Suzuki, H., Hida, T., Sekido, Y., Ariyoshi, Y., and Ueda, R. The p53 gene is very frequently mutated in small-cell lung cancer with a distinct nucleotide substitution pattern. Cancer Res., 52: 734–736, 1992.
6. Maestro, R., Dolcetti, R., Gasparotto, D., Doglioni, C., Pelucchi, S., Barzan, L., Grandi, E., and Boiocchi, M. High frequency of p53 gene alterations associated with protein overexpression in human squamous cell carcinoma of the larynx. Oncogene, 7: 1159–1166, 1992.
7. Martinez, J., Georgoff, I., Martinez, J., and Levine, A. J. Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein. Genes Dev., 5: 151–159, 1991.
8. Diller, L., Kassel, J., Nelson, C. E., Gryka, M. A., Litwak, G., Gebhardt, M., Bressac, B., Ozturk, M., Baker, S. J., Vogelstein, B. and Friend, S. p53 function as a cell cycle control protein in osteosarcomas. Mol. Cell. Biol., 10: 5772–5781, 1990.
9. Shaw, P., Bovey, R., Tardy, S., Sahli, R., Sordat, B., and Costa, J. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. USA, 89: 4495–4499, 1992.
10. Yonish-Rouach, E., Resnitzky, D., Lotem, J., Sachs, L., Kimchi, A., and Oren, M. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature (Lond.), 352: 345–347, 1991.
11. Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and Jacks, T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.), 362: 847–849, 1993.
12. Liu, T.-J., Zhang, W.-W., Taylor, D. L., Roth, J. A., Goepfert, H., and Clayman, G. L. Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Res., 54: 3662–3667, 1994.
13. Clayman, G. L., El-Naggar, A. K., Zhang, W.-W., Taylor, D. L., Roth, J. A., Goepfert, H., and Liu, T-J. In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma. Cancer Res., 55: 1–6, 1995.
14. Gorczyca, W., Gong, J., and Darzynkiewicz, Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res., 53: 1945–1951, 1993.
15. Wijsman, J. H., Jonker, R. R., Keijzer, R., Van De Velde, C. J. H., Cornelisse, C. J., and Van Dierendonck, J. H. A new method to detect apoptosis in paraffin section: in situ end-labeling of fragmented DNA. J. Histochem. Cytochem., 41: 7–12, 1993.
16. El-Deiry, W. S., Harper, J. W., O'Connor, P. M., Velculescu, V. E., Canman, C. E., Jackman, J., Pietenpol, J. A., Burrell, M., Hill, D. E., Wang, Y., Wiman, K. G., Mercer, W. E., Kastan, M. B., Kohn, K. W., Elledge, S. J., Kinzler, K. W., and Vogelstein B. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res., 54: 1169–1174, 1994.
17. Casey, G., Lo-Hsueh, M., Lopez, M. E., Vogelstein, B., and Stanbridge, E. J. Growth suppression of human breast cancer cells by the introduction of a wild-type p53 gene. Oncogene, 6: 1791–1797, 1991.
18. Chen, P. L., Chen, Y. M., Bookstein, R., and Lee, W. H. Genetic mechanisms of tumor suppression by the human p53 gene. Science (Washington DC), 250: 1576–1580, 1990.
19. Zhang, W-W., Fang, X., Mazur, W., French, B. A., Georges, R., and Roth, J. A. High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Ther., 1: 5–13, 1994.
20. Mietz, J. A., Unger, T., Huibregtse, J. M., and Howley, P. M. The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein. EMBO J., 11: 5013–5020, 1992.
21. Wilcock, D., and Lane, D. P. Localization of p53, retinoblastoma, and host replication proteins at sites of viral replication in herpes-infected cells. Nature (Lond.), 349: 429–431, 1991.
22. Clarke, A. R., Purdie, C. A., Harrison, D. J., Morris, R. G., Bird, C. C., Hooper, M. L., and Wyllie, A. H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature (Lond.), 362: 849–852, 1993.
23. Berges, R. R., Furuya, Y., Remington, L., English, H. F., Jacks, T., and Isaacs, J. T. Cell proliferation, DNA repair, and p53 function are not required for programmed cell death of prostatic glandular cells induced by androgen ablation. Proc. Natl. Acad. Sci. USA, 90: 8910–8914, 1993.
24. Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Jr., Butel, J. S., and Bradley, A. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature (Lond.), 356: 215–221, 1992.
25. Ramqvist, T., Magnusson, K. P., Wang, Y., Szekely, L., Klein, G., and Wiman, K. G. Wild-type p53 induces apoptosis in a Burkitt lymphoma (BL) line that carries mutant p53. Oncogene, 8: 1495–1500, 1993.
26. Rao, L., Debbas, M., Sabbatini, P., Hockenbery, D., Korsmeyer, S., and White, E. The adenovirus E1A proteins induce apoptosis which is inhibited by the E1B 19K and Bcl-2 proteins. Proc. Natl. Acad. Sci. USA, 89: 7742–7746, 1992.
27. Wu, X., and Levine, A. J. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA, 91: 3602–3606, 1994.