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5 D'Amico AV, Whittington R, Malkowicz SB, et al.: Clinical utility of the percentage of positive prostate biopsies in defining biochemical outcome after radical prostatectomy for patients with clinically localized prostate cancer. J Clin Oncol 2000, 18:1164-1172. This study is an important study testing the hypothesis that the percentage of positive prostate biopsies provides clinically relevant information about early biochemical failure after radical prostatectomy. In this study, controlling for known prognostic factors, the percentage of positive biopsy samples was an independent predictor of time to PSA failure and was particularly useful in an intermediate-risk group of patients.
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6 Kupelian PA, Mohan DS, Lyons J, et al.: Higher than standard radiation doses (≥ 72 Gy) with or without androgen deprivation in the treatment of localized prostate cancer. Int J Radiat Oncol Biol Phys 2000, 46:567-574. This is an important retrospective analysis of 1041 consecutive localized prostate cancer cases treated with external beam radiotherapy. These preliminary data suggest that patients receiving radiation doses exceeding 72 Gy had significantly better PSA progression-free survival.
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8 D'Amico AV, Schultz D, Loffredo M, et al.: Biochemical outcome following external beam radiation therapy with or without androgen suppression therapy for clinically localized prostate cancer. JAMA 2000, 284:1280-1283. This article is another retrospective study that nevertheless suggests that the addition of 6 months of androgen deprivation to conformal beam radiotherapy improved 5-year biochemical outcome in groups of intermediate-and high-risk patients but not in low-risk patients.
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21 Herr HW, O'Sullivan M: Quality of life of asymptomatic men with nonmetastatic prostate cancer on androgen deprivation therapy. J Urol 2000, 163:1743-1746. This article is a longitudinal evaluation of quality of life in patients treated with androgen deprivation therapy. It is an important study that quantifies what many physicians already know: androgen deprivation may significantly impair the physical and emotional health of otherwise asymptomatic patients with nonmetastatic prostate cancer.
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24 Daniell HW, Dunn SR, Ferguson DW, et al.: Progressive osteoporosis during androgen deprivation therapy for prostate cancer. J Urol 2000, 163:181-186. This important study measured bone marrow density loss in men undergoing androgen deprivation. Although the study did not correlate this bone mineral loss with the likelihood of osteoporotio fractures, it clearly identifies a growing area of interest.
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