Down-regulation of a gene-expression by an antisense BNA oligonucleotide

Folia Pharmacologica Japonica

Volumn 120, Issue 2, 2002, Pages 85-90

  Imanishi, Takeshi ^a   Obika, Satoshi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

Antisense strategy; BNA; Down regulation of a gene expression; Hepatitis C Virus; Oligonucleotide analogue

Indexed keywords

BRIDGED COMPOUND; BRIDGED NUCLEIC ACID; NUCLEIC ACID; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG; VIRUS RNA;

ARTICLE; DOWN REGULATION; GENE EXPRESSION REGULATION; HEPATITIS C VIRUS; INTERNAL RIBOSOME ENTRY SITE; METHODOLOGY; NONHUMAN; NUCLEIC ACID ANALYSIS;

DOWN-REGULATION; GENE EXPRESSION; HEPACIVIRUS; OLIGONUCLEOTIDES, ANTISENSE;

EID: 0036339891     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: 10.1254/fpj.120.85     Document Type: Article

References (15)

1. Antisense oligonucleotides: A new therapeutic principle
2. The synthesis of modified oligonucleotides by the phosphoramidite approach and their applications
3. Current concepts in antisense drug design
4. Synthesis of 2′-O,4′-C-methyle-neuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3′-endo sugar puckering
5. Syntheses and properties of novel conformationally restrained nucleoside analogues
6. BNAs: Novel nucleic acid analogs with a bridged sugar moiety
7. Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyl-eneribonucleosides
8. Inhibition of ICAM-I gene expression by antisense 2′,4′-BNA oligonucleotides
9. Locked nucleic acid (LNA): Fine-tuning the recognition of DNA and RNA
10. DNA analogues: From supramolecular principles to biological properties
11. Inhibition of translation of hepatitis C virus RNA by 2′-modified antisense oligonucleotides
12. 2′-O,4′-C-Methylene bridged nucleic acid (2′,4′-BNA): Synthesis and triplex-forming properties
13. Triplex-forming enhancement with high sequence selectivity by single 2′-O,4′-C-methylene bridged nucleic acid (2′,4′-BNA) modification
14. 2′-O,4′-C-Methylene bridged nucleic acid modification promotes pyrimidine motif triplex DNA formation at physiological pH: Thermodynamic and kinetic studies
15. A 2′, 4′-bridged nucleic acid containing 2-pyridone as a nucleobase: Efficient recognition of a C·G interruption by triplex formation with a pyrimidine motif