Enhancement of circulating dendritic cell activity by immunomodulators (OK432 and KP-40)

Anticancer Research

Volumn 22, Issue 4, 2002, Pages 2137-2145

  Toyokawa, Hideyoshi ^a   Inaba, Muneo ^a   Takai, Soichiro ^a   Satoi, Sohei ^a   Beuth, Josef ^a   Ko, H L ^a   Matsui, Yoichi ^a   Kwon, A Hon ^a   Kamiyama, Yasuo ^a   Ikehara, Susumu ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

BRM; Cancer therapy; Circulating dendritic cells; Immunostimulation; OK432; Propionibacterium avidum KP 40

Indexed keywords

BIOLOGICAL RESPONSE MODIFIER; GLYCOPROTEIN P 15095; IMMUNOMODULATING AGENT; KP 40; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PICIBANIL; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BONE MARROW CELL; CANCER IMMUNOTHERAPY; CELL ACTIVITY; CELL ADHESION; CELL ISOLATION; CELL LINEAGE; CELL TYPE; CONTROLLED STUDY; CORYNEBACTERIUM AVIDUM; CYTOKINE PRODUCTION; DENDRITIC CELL; HEAT TOLERANCE; HUMAN; HUMAN CELL; IMMUNOMODULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; PROPIONIBACTERIACEAE; STREPTOCOCCUS; VACCINATION; VACCINE PRODUCTION;

ADJUVANTS, IMMUNOLOGIC; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; CELLS, CULTURED; DENDRITES; FLOW CYTOMETRY; HUMANS; PICIBANIL; VACCINES, INACTIVATED;

EID: 0036331932     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Immunobiology of dendritic cells
2. Dendritic cells; unique leucocyte populations which control the primary immune response
3. Natural adjuvants: Endogenous activators of dendritic cells
4. A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells
5. Human blood contains two subsets of dendritic cells, one immunologically mature and the other immature
6. Differential regulation of human blood dendritic cell subsets by IFNs
7. The augmenting effect of OK432-stimulated B cells on the in vitro generation of anti-tumor cytotoxic T lymphocytes from tumor-draining lymph node cells: The possible role of interleukin-12
8. The concurrent administration of OK 432 augments the antitumor vaccination effect with tumor cells by sustaining locally infiltrating natural killer cells
9. Antitumor vaccination effect of dendritic cells can be augmented by locally utilizing Th1-type cytokines from OK432-reactive CD4+ T cells
10. Local injections of OK432 can help the infiltration on adoptively transferred CD8+ T cells into the tumor sites and synergistically induce the local production of Th1-type cytokines and CXC3 chemokines
11. The role of hepatic lectins and activity of the mononuclear phagocyte system in systemic Listeria monocytogenes infection in Balb/c mice
12. Combined immunostimulation (Propionibacterium avidum KP-40) and anticoagulation (heparin) prevents metastatic lung and liver colonization in mice
13. Immunostimulation by Propionibacteria-Effects on immune status and antineoplastic treatment
14. Local immunotherapy with Propionibacterium granulosum KP-45 in advanced breast cancer
15. Stimulatory effect of Propionibacterium granulosum KP-45, glucan and pyran copolymer on the activity of natural killer (NK) cells in murine lungs
16. Fermentative and serological studies on Propionibacterium acnes
17. Preoperative immunostimulation by Propionibacterium granulosum KP-45 in colorectal cancer
18. Effect of three strains of Propionibacteria and cell wall preparations on lymphocytes and macrophages
19. Studies on the anticancer and streptolysin S-forming abilities of hemolytic streptococci
20. A MCM is more effective than defined cytokines in mediating the terminal maturation of human DCs
21. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor-α
22. Vaccination with mage-3A1 peptide-pulsed mature, monocyte-derived dendritic cells expands specific cytotoxic T cells and induces regression of some metastases in advanced stage IV melanoma
23. DNA vaccination: Transfection and activation of dendritic cells as key events for immunity
24. In situ tetramer staining of antigen-specific T cells in tissues
25. Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells
26. Reciprocal control of T helper cells and dendritic cell differentiation
27. Dendritic cells produce IL-12 and direct the development of Th1 cells from naïve CD4+ T cells
28. Bone marrow-derived dendritic cells pulsed with synthetic tumor peptides elicit protective and therapeutic antitumor immunity
29. Human dendritic cell responses lipopolysaccharide and CD40 ligation are differentially regulated by interleukin-10
30. Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells