SCOPUS 정보 검색 플랫폼

Volumn 10, Issue 9, 2002, Pages 3001-3010

Structural studies on bioactive compounds. Part 36: Design, synthesis and biological evaluation of pyrimethamine-based antifolates against Pneumocystis carinii

(4) Chan, David C M a Laughton, Charles A a Queener, Sherry F b Stevens, Malcolm F G a

a UNIVERSITY OF NOTTINGHAM (United Kingdom)

b INDIANA UNIVERSITY SCHOOL OF MEDICINE (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINO 5 (3 BENZOYLAMINO 4 CHLOROPHENYL) 6 ETHYLPYRIMIDINE; 2,4 DIAMINO 5 [3 (3,4,5 TRIMETHOXYBENZOYL)AMINO 4 CHLOROPHENYL] 6 ETHYLPYRIMIDINE; 2,4 DIAMINO 5 [3 [N (BENZYL) N METHYLAMINO] 4 CHLOROPHENYL] 6 ETHYLPYRIMIDINE; 2,4 DIAMINO 5 [4 CHLORO 3 (1,2,3 TRIAZOL 1 YL)PHENYL] 6 ETHYLPYRIMIDINE; 2,4 DIAMINO 5 [4 CHLORO 3 (4 PHENYL 1,2,3 TRIAZOL 1 YL)PHENYL] 6 ETHYLPYRIMIDINE; 2,4 DIAMINO 5 [4 CHLORO 3 (4 TRIMETHYLSILYL 1,2,3 TRIAZOL 1 YL)PHENYL] 6 ETHYLPYRIMIDINE; 2,4 DIAMINO 5 [4 CHLORO 3 [N (BENZYL)AMINO]PHENYL] 6 ETHYLPYRIMIDINE; ANTIPROTOZOAL AGENT; FOLIC ACID ANTAGONIST; PYRIMETHAMINE; UNCLASSIFIED DRUG; DIHYDROFOLATE REDUCTASE; TRIAZINE DERIVATIVE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; IC 50; NONHUMAN; PNEUMOCYSTIS CARINII; PNEUMOCYSTIS PNEUMONIA; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL STRUCTURE; DRUG EFFECT; ENZYMOLOGY; LIVER; MYCOBACTERIUM AVIUM; PNEUMOCYSTIS; SPECIES DIFFERENCE; SYNTHESIS; TOXOPLASMA;

PNEUMOCYSTIS CARINII;

ANIMALS; DRUG DESIGN; FOLIC ACID ANTAGONISTS; INHIBITORY CONCENTRATION 50; LIVER; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM AVIUM; PNEUMOCYSTIS; PYRIMETHAMINE; RATS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROFOLATE DEHYDROGENASE; TOXOPLASMA; TRIAZINES;

EID: 0036314961 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/S0968-0896(02)00128-1 Document Type: Article

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