Identification of a class of sulfonamides highly active against dihydropteroate synthase from Toxoplasma gondii, Pneumocystis carinii, and Mycobacterium avium

Antimicrobial Agents and Chemotherapy

Volumn 40, Issue 3, 1996, Pages 727-733

  Chio, Li Chun ^a   Bolyard, Lori A ^a   Nasr, Mohamed ^b   Queener, Sherry F ^a  

^a INDIANA UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; DIHYDROPTEROATE SYNTHASE; PROTOZOAL PROTEIN; SULFADIAZINE; SULFAMETHOXAZOLE; SULFONAMIDE;

ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG EFFECT; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; ESCHERICHIA COLI; MYCOBACTERIUM AVIUM; NONHUMAN; PNEUMOCYSTIS CARINII; PRIORITY JOURNAL; TOXOPLASMA GONDII;

EID: 0030052421     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.40.3.727     Document Type: Article

References (22)

1. Allegra, C. J., D. Boarman, J. A. Kovacs, et al. 1990. Interaction of sulfonamide and sulfone compounds with Toxoplasma gondii dihydropteroate synthase. J. Clin Invest 85:371-379.
2. Atzori, C., A. Bruno, G. Chichino, E. Bombardelli, M. Scaglia, and M. Ghione. 1993. Activity of bilobalide, a sesquiterpene from Ginkgo biloba, on Pneumocystis carinii. Antimicrob. Agents Chemother. 37:1492-1496.
3. Bartlett, M. S., T. D. Edlind, M. M. Durkin, M. M. Shaw, S. F. Queener, and J. W. Smith. 1992. Antimicrotubule benzimidazoles inhibit in vitro growth of Pneumocystis carinii Antimicrob. Agents Chemother. 36:779-782.
4. Bartlett, M. S., J. A. Fishman, M. M. Durkin, S. F. Queener, and J. W. Smith. 1990. Pneumocystis carinii: improved models to study efficacy of drugs for treatment or prophylaxis of Pneumocystis pneumonia in the rat (Rattus spp.) Exp. Parasitol. 70:100-106.
5. Bartlett, M. S., S. F. Queener, M. M. Shaw, J. D. Richardson, and J. W. Smith. 1994. Pneumocystis carinii is resistant to imidazole antifungal agents. Antimicrob Agents Chemother. 38:1859-1861.
6. Broughton, M. C., and S. F. Queener. 1991. Pneumocystis carinii dihydrofolate reductase used to screen potential antipneumocystis drugs. Antimicrob. Agents Chemother. 35:1348-1355.
7. Chio, L. C., and S. F. Queener. 1993. Identification of highly potent and selective inhibitors of Toxoplasma gondii dihydrofolate reductase Antimicrob. Agents Chemother. 37:1914-1923
8. Durkin, M. M., M. S. Bartlett, S. F. Queener, M. M. Shaw, C. H. Lee, and J. W. Smith. 1992. An enzyme-linked immunosorbent assay for enumeration of Pneumocystis carinii in vitro and in vivo. J. Clin. Microbiol. 30:3258-3262.
9. Eagon, R. G., and A. T. McManus. 1989. Phosphanilic acid inhibits dihydropteroate synthase. Antimicrob. Agents Chemother. 33:1936-1938.
10. Fedrick, J. L., and R. G. Shepherd. 1961 Fluorosulfanilanilides. J. Org. Chem 26:4715-4716.
11. Fishman, J. A., S. F. Queener, R. S. Roth, and M. S. Bartlett. 1993. Activity of topoisomerase inhibitors against Pneumocystis cannii in vitro and in an inoculated mouse model. Antimicrob. Agents Chemother. 37:1543-1546.
12. Hong, Y. L., P. A. Hossler, D. H. Calhoun, and S. R. Meshnick. 1995. Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob. Agents Chemother. 39:1756-1763
13. Lever, O. W., Jr., L. N. Bell, H. M. McGuire, and R. Ferone. 1985. Monocyclic pteridine analogues. Inhibition of Eschenchia coli dihydropteroate synthase by 6-amino-5-nitrosoisocytosines. J. Med. Chem. 28:1870-1874
14. Merali, S., and S. R. Meshnick. 1991. Susceptibility of Pneumocystis carinii to artemisinin in vitro Antimicrob. Agents Chemother. 35:1225-1227.
15. Merali, S., Y. Zhang, D. Sloan, and S. Meshnick. 1990. Inhibition of Pneumocystis curinii dihydropteroate synthetase by sulfa drugs. Antimicrob. Agents Chemother. 34:1075-1078.
16. Nasr, M., K. D. Paull, and V. L. Narayanan. 1984. Computer assisted structure-activity correlations. Adv. Pharmacol Chemother. 20:123-190.
17. Queener, S. F., M. S. Bartlett, M. Nasr, and J. W. Smith. 1993. 8-Aminoquinolines effective against Pneumocystis carinii in vitro and in vivo. Antimicrob. Agents Chemother. 37:2166-2172.
18. Queener, S. F., M. S. Bartlett, J. D. Richardson, M. M. Durkin, M. A. Jay, and J. W. Smith. 1988. Activity of clindamycin with primaquine against Pneumocystis carinii in vitro and in vivo. Antimicrob. Agents Chemother. 32: 807-813.
19. Queener, S. F., II. Fujioka, Y. Nishiyama, H. Furukawa, M. S. Bartlett, and J. W. Smith. 1991. In vitro activities of acridone alkaloids against Pneumocystis carinii Antimicrob Agents Chemother. 35:377-379.
20. Rosowsky. A., J. II. Freisheim, J. B. Hynes, et al. 1989 Tricyclic 2,4-diaminopyrimidines with broad antifolate activity and the ability to inhibit Pneumocystis carinii growth in cultured human lung fibroblasts in the presence of leucovonn. Biochem. Pharmacol. 38:2677-2684.
21. Segel, I. H. 1975. Enzyme kinetics. Behavior and analysis of rapid equilibrium and steady-state enzyme systems, p. 957. Wiley-Interscience, New York.
22. Voeller, D., J. Kovacs, V. Andrawis, E. Chu, H. Masur, and C. Allegra. 1994. Interaction of Pneumocystis carinii dihydropteroate synthase with sulfonamides and diaminodiphenyl sulfone (dapsone). J. Infect Dis 169:456-459.