Procathepsin D interacts with prosaposin in cancer cells but its internalization is not mediated by LDL receptor-related protein

Experimental Cell Research

Volumn 277, Issue 2, 2002, Pages 210-219

  Laurent Matha, Valérie ^a   Lucas, Annick ^a   Huttler, Silke ^b   Sandhoff, Konrad ^b   Garcia, Marcel ^a   Rochefort, Henri ^a  

^a INSERM   (France)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Breast cancer; Cathepsin D; Endocytosis; LDL receptor related protein; M6P receptors; Prosaposin

Indexed keywords

AMMONIUM CHLORIDE; CATHEPSIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; PROCATHEPSIN D; PROSAPOSIN; RECEPTOR ASSOCIATED PROTEIN; RECEPTOR PROTEIN; SOMATOMEDIN B RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER CELL; CONTROLLED STUDY; CROSS LINKING; ENDOCYTOSIS; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTERNALIZATION; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; RAT;

EID: 0036311034     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2002.5556     Document Type: Article

References (45)

1. Endocytosis of pro-cathepsin D into breast cancer cells is mostly independent of mannose-6-phosphate receptors
2. The prognostic value of cathepsin D in breast cancer. A long road to the clinic
3. Relationship between cathepsin D content and disease-free survival in node-negative breast cancer patients: A meta-analysis
4. Cathepsin D in primary breast cancer: Prognostic evaluation involving 2810 patients
5. Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency
6. Cathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signal
7. Cathepsin D in cancer metastasis: A protease and a ligand
8. Autocrine growth stimulation of the MCF-7 breast cancer cells by the estrogen regulated 52 K protein
9. Specific mannose-6-phosphate receptor-independent sorting of pro-cathepsin D in breast cancer cells
10. Mis-sorting of procathepsin D in metastogenic tumor cells is not due to impaired synthesis of the phosphomannosyl signal
11. Phosphorylation, glycosylation and proteolitye activity of the 52 kDa oestrogen-induced protein secreted by MCF-7 cells
12. Cathepsin D is membrane associated in macrophage endosomes
13. Mannose-6-phosphate independent targeting of cathepsin D to lysosomes in HepG2 cells
14. Procathepsin L and D are membrane bound in acidic microsomal vesicles
15. Saposins proteins: Structure, function, and role in human lysosomal storage disorders
16. Activator proteins and topology of lysosomal sphingolipid catabolism
17. Saposins and their interaction with lipids
18. Intermolecular association of lysosomal protein precursors during biosynthesis
19. Expression of the three alternative forms of the sphingolipid activator protein precursor in baby hamster kidney cells and functional assays in a cell culture system
20. Biosynthesis, processing, and targeting of sphingolipid activator protein (SAP) precursor in cultured human fibroblasts
21. Cellular uptake of saposin (SAP) precuror and lysosomal delivery by the low density lipoprotein receptor-related protein (LRP)
22. Structures and functions of multiligand lipoprotein receptors: Macrophage scavenger receptors and LDL receptor-related protein (LRP)
23. 39 kDa protein modulates binding of ligands to low density lipoprotein receptor related protein α2-macroglobulin receptor
24. RAP, a novel type of ER chaperone
25. Characterisation of monoclonal antibodies to the estrogen-regulated Mr 52,000 glycoprotein and their use in MCF-7 cells
26. pH dependent conformational properties of saposins and their interactions with phospholipid membranes
27. Human cathepsin precursor is associated with a 60 kDa glycosylated polypeptide
28. Estradiol. stimulates cell growth and secretion of procathepsin D and a 120 kDa protein in the human ovarian cancer cell line BG1
29. 2-macroglobulin receptor in human breast carcinomas
30. Cathepsin D in breast cancer: Mechanism and clinical applications, a 1999 overview
31. A mutated cathepsin D devoid of its catalytic activity stimulates the growth of cancer cells
32. A mutated cathepsin D devoid of its catalytic activity stimulated the growth of cancer cells
33. Secretion of prosaposin, a multifunctional protein, by breast cancer cells
34. Alternative mechanisms for trafficking of lysosomal enzymes in mannose-6-phosphate receptor-deficient mice are cell type-specific
35. Differential sorting of lysosomal enzymes in mannose-6-phosphate receptor deficient fibroblasts
36. Mannose-6-phosphate independent targeting of lysosomal enzyme in I cell disease B lymphoblasts
37. Prosaposin receptor: Evidence for a G protein associated receptor
38. Prosaposin, a neurotrophic factor: Presence and properties in milk
39. Human breast milk contains pro-cathepsin D detection by specific antibodies
40. Mice deficient for lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells
41. Lysosomal proteolysis of prosaposin, the precursor of saposins (sphingolipid activator protein): Its mechanism and inhibition by ganglioside
42. Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides
43. 2-macroglobulin receptor regulates cell surface plasminogen activator activity on human trophoblast cells
44. r 40,000 receptor associated protein