Endocytosis of pro-cathepsin D into breast cancer cells is mostly independent of mannose-6-phosphate receptors

Journal of Cell Science

Volumn 111, Issue 17, 1998, Pages 2539-2549

  Laurent Matha, Valérie ^a   Farnoud, Mohamad Reza ^a,b   Lucas, Annick ^a   Rougeot, Christian ^a   Garcia, Marcel ^a   Rochefort, Henri ^a  

^a INSERM   (France)

^b HÔPITAL TENON   (France)

Author keywords

Breast cancer; Cathepsin D; Endocytosis; Mannose 6 phosphate IGFII receptor

Indexed keywords

CATHEPSIN D; MANNOSE 6 PHOSPHATE; SOMATOMEDIN B RECEPTOR;

ARTICLE; CANCER CELL; CELL STRAIN MCF 7; CONFOCAL MICROSCOPY; ENDOCYTOSIS; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; INTERNALIZATION; PRIORITY JOURNAL;

ANTIBODIES; ANTIBODY SPECIFICITY; BIOLOGICAL TRANSPORT, ACTIVE; BREAST NEOPLASMS; CATHEPSIN D; ENDOCYTOSIS; ENZYME PRECURSORS; FEMALE; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INTRACELLULAR FLUID; MANNOSEPHOSPHATES; PROTEIN BINDING; RECEPTOR, IGF TYPE 2; SULFUR RADIOISOTOPES; TUMOR CELLS, CULTURED;

EID: 0031709904     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Brouillet, J. P., Spyratos, F., Hacene, K., Fauque, J., Freiss, G., Dupont, F., Maudelonde, T. and Rochofort, H. (1993). Immunoradiometric assay of pro-cathepsin D in breast cancer cytosol: Relative prognostic value versus total calhepsin D. Eur. J. Cancer 29A, 1248-1251.
2. Bnmillet, J. P., Dufour, F., Lemamy, G., Garcia, M. Schlup N., Grenier, J., Manni, J. C. and Rochefort, H. (1997). Increased calhepsin D level in serum of metasiatic breast cancer patients detected with a specific procathepsin-D immunoassay. Cancer 79, 2132-2136.
3. Cailleau, R., Young, R., Olive, M. and Reeves, W. J. (1974). Breast tumor cell lines from pleural effusions. J. Natl. Cancer Inst. 53, 661-674.
4. Capony, F., Morisset, M., Barrett, A. J., Capony, JP, Broquet, P., Vignon, F., Chambon, M., Louisot, P. and Rochefort, H. (1987). Phosphorylation, glycosylation and proteolytic activity of the 52 kD estrogen-induced protein secreted by MCF7 cells. J. Cell Biol. 104, 253-262.
5. Capony, F., Braulke, T., Rougeot, C., Roux, S., Montcourrier, P. and Rochefort H. (1994). Specific Mannose-6-Phosphate receptor-independant sorting of pro-cathepsin D in breast cancer cells. Exp. Cell Res. 215, 154-163.
6. Capony, F., Rougeot, C., Montcourier, P., Cavaillès, V., Salazar, G. and Rochefort H. (1989). Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cells. Cancer Res. 49, 3904-3909.
7. Chapman, R. E. and Munro, S. (1994). Retrieval of TGN proteins from the cell surface requires endosomal acidification. EMBO J. 13, 2305-2312.
8. Confort, C., Rochefort, H. and Vignon, F. (1995). Insulin-like growth factors (IGFs) stimulate the release of 1-antichymotrypsin and soluble IGF-II/mannose-6-Phosphate receptor from MCF-7 breast cancer cells. Endocrinology 136, 3759-3766
9. Corvera, S., Folander, K., Clairmont, K. B. and Czech, M. P. (1988). A highly phosporylated subpopulation of insulin-like growth factor II/mannose 6-Phosphate receptors is concentrated in a clathrin-enriched plasma membrane fration. Proc. Natl. Acad. Sci. USA 85, 7567-7571.
10. De Souza, A., Hankins, G. R., Washington, M. K., Orton, T. C. and Jirtle, R. L. (1995). M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. Nature Genetics 11, 447-449.
11. Diment, S., Leech, M. S. and Stahl, P. D. (1988). Cathepsin D is membrane-associated in macrophages endosomes. J. Biol. Chem. 263, 6901-6907.
12. r 52,000 precursor of cathepsin D in human breast cancer cells. Cancer Res. 48, 3709-3715.
13. Fusek, M. and Vetvicka, V. (1994). Mitogenic function of human procathepsin D: the role of the propeptide. Biochem J. 303, 775-780.
14. r 52,000 glycoprotein and their use in MCF-7 cells. Cancer Res. 45, 709-716.
15. Gottesman, M. M. (1990). Introduction: Do proteases play a role in cancer? Semin. Cancer Biol. 1, 97-98.
16. Griffiths, J. R. (1991). Are cancer cells acidic? Br. J. Cancer 64, 425-427.
17. Harter, C. and Mellman, I. (1992). Transport of the lysosomal membrane glycoprotein Igp120 (Igp-A) to lysosomes does not require appearance on the plasma membrane. J. Cell Biol. 117, 311-325.
18. Isodoro, C., Baccino, F. M. and Hasilik, A. (1997). Mis-sorting of procathepsin D in metastogenic tumor cells is not due to impaired synthesis of the phosphomannosyl signal. Int. J. Cancer 70, 561-566.
19. Kiess, W., Haskell, J. F., Lee, L., Greenstein, L. A., Miller, B. E., Aarons, A. L., Rechler, M. M. and Nissley, S. P. (1987). An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimuluted biologic responses in L6 Myoblasts. J. Biol Chem. 262, 12745-12751.
20. Klumperman, J., Mille, A., Veenendaal, T., Oorschot, V., Stoorvogel, W., Von Figura, K. and Geuze, H. J. (1993). Differences in the endosomal distribution of the two Mannose 6-Phosphate receptors. J. Cell. Biol. 121, 997-1010.
21. Liaudet, E., Garcia, M. and Rochefort H. (1994). Cathepsin D maturation and its stimulatory effect on metastasis are prevented by addition of KDEL retention signal. Oncogene 9, 1145-1154.
22. Mathieu, M., Vignon, F., Capony, F. and Rochefort, H. (1991). Estradial down-regulates the Mannose-6-Phosphate/insulin-like growth factor-11 receptor gene and induces cuthepsin-D in breast cancer cells: A receptor saturation mechanism to increase the secretion of lysosomal proenzymes. Molecular Endocrinol. 5, 815-822.
23. Maudelonde, T. and Rochefort, H. (1987). A 51 progestin-regulated protein secreted by human endometrial cells in primary culture. J. Clin. Enodocrinal. Metab. 64, 1294-1301.
24. McIntyre, G. F. and Krickson, A. H. (1993). The lysosomal proenzyme receptor that binds procathepsin L to microsomal membranes at pH 5 is a 43-kDa integral membrane protein. Proc. Nat. Acad. Sci. USA 90, 10588-10592.
25. Montcourrier, P. Mangeat, P. H., Valembois, C., Salazar, G., Sahuquet, J., Duperray, C. and Rochefort, H. (1994) Characterization of very acidic phagosomes in breast cancer cells and their association with invasion. J. Cell Sci. 107, 2381-2391, 1994.
26. Montcourrier, P., Silver, I. A., Farnoud, R., Bird, I. and Rochefort, H. (1997). Invasive breast cancer cells have a high capacity to acidify extracellular milieu. Exp. Clin. Metast. 15, 382-392.
27. Pohlmann, R., Wendland, M., Boeker, C. and Von Figura, K. (1995). The two Mannose-6-Phosphate receptors transport distinct complements of lysosomal proteins. J. Biol. Chem. 270, 27311-27318.
28. Reilly, J. J., Jr., Chen, P., Zenzius, L., Sailor, Mason, R. W. and Chapman, H. A., Jr. (1990). Uptake of extracellular enzyme by a novel pathway is a major determinant of calhepsin L levels in human macrophages. J. Clin. Invest. 86, 176-183.
29. Rijnboutt, S., Kal, A., Geuze, H., Aerts, H. and Strous, G. (1991). Munnose-6-Phosphate-independent targeting of cathepsin D to lysosomes in hepG2 cells. J. Biol. Chem. 266, 23586-23592.
30. Rio, M. C., Bellocq, J. P., Gairard, B. Rasmussen, U. B., Krust, A. Koehl, C., Calderoli, H., Schiff, V., Renaud, R. and Chambon, P. (1987) Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogcne ERBB2. Proc. Nat. Acad. Sci. USA 84, 9243-9247.
31. Rochefort, H., Capony, F., Garcia, M., Cavaillès, Y., Freiss, G., Chambun, M., Morisset, M. and Vignon, F. (1987). Estrogen-induced lysosomal proteases secreted by breast cancer cells. A role in carcinogenesis? J. Cell Biochem. 35, 17-29.
32. Sloane, B. F. (1990). Cathepsin B and cystatins: evidence for a role in cancer progression. Semin. Cancer Biol. 1, 137-152.
33. Soule, H. D., Vazquez, J., Long, A., Albert, S. and Bernnan, M. B. (1973). A human cell line from a pleural effusion derived from a breast carcinoma. J. Nat. Cancer Inst. 51, 1409-1416.
34. Unkeless, J. C., Scigliono, E. and Freedman, F. H. (1988). Structure and function of human and murine receptors for IgG. Ann. Rev. Iminunol. 6, 251-281.
35. Vetvicka, V., Vetvickava, J., Hilbery, I., Voburka, Z. and Fusek, M. (1997). Analysis of the interaction of pro-cathepsin-D activation peptide with breast cancer cells. Int. J. Cancer 73, 403-409.
36. Vignon, F., Capony, F., Chambon, M., Freiss, G., Garcia, M. and Rochefort, H. (1986). Autocrine growth stimulation of the MCF7 breast cancer cells by the estrogen-regulated 52K protein. Endocrinologv 118, 1537-1545.
37. Von Figura, K. and Hasilik, A. (1986). Lysosomal enzymes and their receptors. Ann. Rev. Riochem. 55, 167-193.
38. Westley, B. and Rochefort, H. (1980). A secreted glycoprotein induced by estrogen in human breast cancer cell lines. Cell 20, 352-362.
39. Zhao, Y., Escot, C., Maudelonde, T., Puech, C., Rouanet, P. and Rochefort, H. (1993). Correlation between Mannose-6-Phosphate/IGFII receptor and cathepsin D RNA levels by in situ hybridization in benign and malignant mammary tumors. Cancer Res. 53, 2901-2905.
40. Zhu, Y. and Conner, G. E. (1994). Imermolecuiar association of lysosomal protein precursors during biosynthesis. J. Biol. Chem. 269, 3846-3851.