Elongation factor 2 as a target for selective inhibition of protein synthesis in vitro by the novel aromatic bisamidine

Molecular and Cellular Biochemistry

Volumn 233, Issue 1-2, 2002, Pages 159-164

  Gajko Galicka, Anna ^a   Bielawski, Krzysztof ^a   Sredzinska, Krystyna ^a   Bielawska, Anna ^a   Gindzienski, Andrzej ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

Aromatic bisamidines; Eukaryotic elongation factor 2; Protein synthesis

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; ADENOSINE DIPHOSPHATE; AMIDINE; ANTINEOPLASTIC AGENT; AROMATIC COMPOUND; BISAMIDINE 1; CARBON 14; CISPLATIN; CONGOCIDINE; DIPHTHERIA TOXIN; ELONGATION FACTOR 1; ELONGATION FACTOR 2; FURIMIDAZOLINE; IMIDAZOLINE DERIVATIVE; LEUCINE; PENTAMIDINE; UNCLASSIFIED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL CULTURE; CELL FREE SYSTEM; CELL ISOLATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG TARGETING; EUKARYOTIC CELL; GENE TRANSLOCATION; IN VITRO STUDY; LIVER CELL; NONHUMAN; PROTEIN PURIFICATION; PROTEIN SYNTHESIS INHIBITION; RAT; RIBOSOME; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL-FREE SYSTEM; FURANS; LEUCINE; MICROSOMES, LIVER; PEPTIDE ELONGATION FACTOR 2; PROTEIN SYNTHESIS INHIBITORS; RATS; RIBOSOMES;

ANIMALIA; EUKARYOTA;

EID: 0036307138     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015548131930     Document Type: Article

References (24)

1. Relationships between inhibition, sequence-specificity and DNA binding mode of dicationic diphenylfuran derivatives
2. New direction in the design of anticancer drugs
3. Dicationic diarylfurans as anti-Pneumocystis carinii agents
4. DNA-binding activity and biological effects of aromatic polyamides
5. Effects of minor groove binding drugs on the interaction of TATA box binding protein and TFIIA with DNA
6. Sequence-specific DNA minor groove binders. Design and synthesis of netropsin and distamycin analogues
7. Cytotoxicity of bis(phenylamidinium)furan alkyl derivatives in human tumour cell lines: Relation to DNA minor groove binding
8. Eukaryotic protein synthesis
9. Eukaryotic protein elongation factors
10. Purification and characterization of the protein kinase eEF-2 isolated from rat liver cells
11. 2+ and calmodulin-dependent protein kinase III
12. Cellular ADP-ribosyltransferase with the same mechanism of action as diphtheria toxin and Pseudomonas toxin A
13. Mechanism of action of Pseudomonas aeruginosa exotoxin A: Adenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivo
14. Inhibitory effects of pentamidine analogues on protein biosynthesis in vitro
15. The binding of amino acyl transferase II to ribosomes
16. Purification of aminoacyltransferase II (translocation factor) from rat liver
17. 14C-amino acyl soluble-tRNA
18. Multiformity of elongation factor eEF-2 isolated from rat liver cells
19. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
20. Estimating the amounts of ADP-ribosylatable active elongation factor-2 in mammalian cell-free extracts
21. 14C in polyacrylamide gels by fluorography
22. Possibility of the transformation of eEF-2 (100 kDa) to eEF-2 (65 kDa) in the peptide elongation process in vitro
23. Cytoplasmic inhibitor of eEF-2ADP-ribosylation catalyzed by diphtheria toxin or endogenous transferase in rat liver cells
24. Characterization of the ribosomal properties required for formation of a GTPase active complex with the eukaryotic elongation factor 2