Involvement of DNA polymerase β in DNA replication and mutagenic consequences

Journal of Molecular Biology

Volumn 315, Issue 5, 2002, Pages 1039-1047

  Servant, Laurence ^a   Bieth, Anne ^a   Hayakawa, Hiroshi ^b   Cazaux, Christophe ^a   Hoffmann, Jean Sébastien ^a  

^a CNRS   (France)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

Cancer; DNA polymerases; DNA replication; Mutagenesis

Indexed keywords

CELL EXTRACT; DNA DIRECTED DNA POLYMERASE BETA; DOUBLE STRANDED DNA; GUANOSINE TRIPHOSPHATE DERIVATIVE; NUCLEOTIDE;

ARTICLE; CANCER CELL; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYME PURIFICATION; ERROR; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MAMMAL CELL; MUTAGENESIS; OXIDATION; PRIORITY JOURNAL; PROTEIN STABILITY;

MAMMALIA;

EID: 0036300448     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5307     Document Type: Article

References (30)

1. Requirement of mammalian DNA polymerase-beta in base-excision repair
2. Characterization of DNA polymerase beta mRNA: Cell-cycle and growth response in cultured human cells
3. Delayed DNA joining at 3′ mismatches by human DNA ligases
4. Over-expression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs
5. Overexpression of DNA polymerase beta: A genomic instability enhancer process
6. Overexpression of DNA polymerase β sensitizes mammalian cells to 2′,3′-dideoxyxytidine and 3′-azido-3′-deoxythymidine
7. Incorporation of the guanosine triphosphate analogs 8-oxo-dGTP and 8-NH2-dGTP by reverse transcriptases and mammalian DNA polymerases
8. Frame-shift fidelity during replication of double-stranded DNA in HeLa cell extracts
9. DNA polymerase beta expression differences in selected human tumors and cell lines
10. The fidelity of the human leading and lagging strand DNA replication apparatus with 8-oxodeoxy-guanosine triphosphate
11. Human breast cancer cells contain an error-prone DNA replication apparatus
12. The mutational specificty of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations
13. DNA replication fidelity with 8-oxo-deoxyguanosine triphosphate
14. Hetero-duplex repair in extracts of human Hela cells
15. 8-OxodGTP incorporation by DNA polymerase beta is modified by active-site residue Asn279
16. Mammalian base excision repair and DNA polymerase beta
17. Mammalian DNA polymerase beta can substitute for DNA polymerase I during DNA replication in Escherichia coli
18. Nucleotide excision repair DNA synthesis by excess DNA polymerase beta: A potential source of genetic instability in cancer cells
19. Fidelity and processivity of Saccharomyces cerevisiae of DNA polymerase eta
20. Low fidelity DNA synthesis by human DNA polymerase-eta
21. A plethora of lesion-replicating DNA polymerases
22. Enzymes of evolutionary change
23. Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa
24. Poliota, a remarkably error-prone human DNA polymerase
25. Proofreading of DNA polymerase eta-dependent replication errors
26. Different mutator phenotypes in Mlh1- versus Pms2- deficient mice
27. Studies of the domain structure of mammalian DNA polymerase beta
28. Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: Sanitization of nucleotide pool
29. Fidelity of DNA replication