Activation mechanism of solubilized epidermal growth factor receptor tyrosine kinase

Biochemical and Biophysical Research Communications

Volumn 290, Issue 3, 2002, Pages 914-920

  Ge, Gaoxiang ^a   Wu, Jing ^a   Wang, Yan ^a   Lin, Qishui ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

Activation; EGF receptor; Epidermal growth factor (EGF); Mechanism; Receptor tyrosine kinase

Indexed keywords

ADENOSINE TRIPHOSPHATE; DIMER; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; MUTANT PROTEIN; PHOSPHATE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DIMERIZATION; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME STABILITY; MOUSE; NONHUMAN; PHOSPHATE TRANSPORT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; WILD TYPE;

EID: 0036295963     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6285     Document Type: Article

References (45)

1. Tissue-specific transformation by oncogenic mutants of epidermal growth factor receptor
2. The epidermal growth factor
3. Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor
4. Self-phosphorylation of epidermal growth factor receptor: Evidence for a model of intermolecular allosteric activation
5. Signal transmission by epidermal growth factor receptor: Coincidence of activation and dimerization
6. Evidence that autophosphorylation of solubilized receptors for epidermal growth factor is mediated by intermolecular cross-phosphorylation
7. Self-phosphorylation of epidermal growth factor receptor is an intermolecular reaction
8. A point mutation at the ATP-binding site of the EGF-receptor abolishes signal transduction
9. Expression of epidermal growth factor receptors on human cervical, ovarian, and vulval carcinomas
10. Expression profiles of Erb B family receptors and prognosis in primary transitional cell carcinoma of the urinary bladder
11. Expression and clinical significance of erb-B receptor family in hepatocellular carcinoma
12. Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase
13. Tyrosine kinase signaling in breast cancer: Epidermal growth factor receptor and c-Src interactions in breast cancer
14. Evidence for the differential expression of a variant EGFR protein in human prostate cancer
15. The EGFR family as targets for cancer therapy
16. Epidermal growth factor receptor tyrosine kinase as target for anticancer therapy
17. Real-time measurement of kinetic of EGF binding to soluble EGFR monomers and dimers support the dimerization model for receptor activation
18. Activation of epidermal growth factor receptor by epidermal growth factor
19. EGF induces increased ligand binding affinity and dimerization of soluble epidermal growth factor (EGF) receptor extracellular domain
20. Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bond
21. Mechanism of epidermal growth factor receptor autophosphorylation and high-affinity binding
22. Antibody-induced dimerization activates the epidermal growth factor receptor tyrosine kinase
23. Stearylamine liposome as a new efficient reagent for DNA transfection of eukaryotic cells
24. Inhibition of tyrosine kinase activity of the epidermal growth factor (EGF) receptor by a truncated receptor form that binds to EGF: Role for interreceptor interaction in kinase regulation
25. The secreted form of the epidermal growth factor receptor. Characterization and crystallization of the receptor-ligand complex
26. Biological activities of EGF-receptor mutants with individually altered autophosphorylation sites
27. Anti-oncogenic activity of signaling-defective epidermal growth factor receptor mutants
28. A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization
29. Two EGF molecules contribute additively to stabilization of the EGF dimer
30. The kinase domain and membrane localization determine intracellular interactions between epidermal growth factor receptors
31. A model for the activation of the epidermal growth factor receptor kinase: Involvement of an asymmetric dimer?
32. Alteration of epidermal growth factor receptor activity by mutation of its primary carboxylterminal site of tyrosine self-phosphorylation
33. The biological activity of the human epidermal growth factor receptor is positively regulated by its C-terminal tyrosines
34. Multiple autophosphorylation site mutations of the epidermal growth factor receptor. Analysis of kinase activity and endocytosis
35. Insufficiency of self-phosphorylation for the activation of epidermal growth factor receptor
36. Identification of residues in the nucleotide binding site of the epidermal growth factor receptor/kinase
37. Nucleotide binding properties of kinase deficient epidermal growth factor receptor mutants
38. Kinetic model of the epidermal growth factor (EGF) receptor tyrosine kinase and a possible mechanism of its activation by EGF
39. Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor
40. Single-molecule imaging of EGFR signaling on the surface of living cells
41. Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: A mechanism for receptor transregulation
42. Secondary dimerization between the epidermal growth factor receptor family
43. Cholesterol and phosphoinositides increase affinity of the epidermal growth factor receptor
44. Sequence-related behaviour of transmembrane domains from class I receptor tyrosine kinases
45. Effect of membrane fluidity on tyrosine kinase activity of reconstituted growth factor receptor