Dioxin-induced adseverin expression in the mouse thymus is strictly regulated and dependent on the aryl hydrocarbon receptor1

Biochemical and Biophysical Research Communications

Volumn 291, Issue 5, 2002, Pages 1194-1200

  Svensson, Camilla ^a   Lundberg, Katarina ^a   Silverstone, Allen E ^b   Lai, Zhi Wei ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

Author keywords

2, 3, 7, 8 tetrachlorodibenzo p dioxin; Ad severin; AhR; Chim era; TCDD; Thymocyte; Thymus

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; DEXAMETHASONE; DIOXIN; ESTRADIOL; PROTEIN; PROTEIN ADSEVERIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INDUCTION; HEMATOPOIETIC CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA; THYMOCYTE; THYMUS ATROPHY;

EID: 0036295453     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2002.6582     Document Type: Article

References (26)

1. Non-carcinogenic effects of TCDD in animals
2. The PAS superfamily: Sensors of environmental and developmental signals
3. Immune-specific up-regulation of adseverin gene expression by 2, 3, 7, 8-tetrachloro-dibenzo-p-dioxin
4. Calcium regulation of gelsolin and adseverin: A natural test of the helix latch hypothesis
5. Chromaffin cell scinderin, a novel calcium-dependent actin filament-severing protein
6. An antisense oligodeoxynucleotide targeted to chromaffin cell scinderin gene decreased scinderin levels and inhibited depolarization-induced cortical F-actin disassembly and exocytosis
7. Cortical filamentous actin disassembly and scinderin redistribution during chromaffin cell stimulation precede exocytosis, a phenomenon not exhibited by gelsolin
8. Expression of scinderin in megakaryoblastic leukemia cells induces differentiation, maturation, and apoptosis with release of platelet-like particles and inhibits proliferation and tumorigenesis
9. Thymic alterations induced by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin are strictly dependent on aryl hydrocarbon receptor activation in hemopoietic cells
10. Thymic stroma exposed to arylhydrocarbon receptor-binding xenobiotics fails to support proliferation of early thymocytes but induces differentiation
11. Evidence for direct action of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on thymic epithelium
12. Effect of chronic or cyclic exposure to estradiol on the humoral immune response and the thymus
13. Glucocorticoid action on the immune system
14. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) alters intrathymic T-cell development in mice
15. Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: Application in the production of chimeric thymus rudiments
16. Cytokine gene expression during ontogeny in murine thymus on activation of the aryl hydrocarbon receptor by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin
17. Overexpression of the anti-apoptotic oncogene, bcl-2, in the thymus does not prevent thymic atrophy induced by estradiol or 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin
18. Dexamethasone and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin can induce thymic atrophy by different mechanisms in mice
19. Ontogenic development of murine fetal thymocytes is accelerated by 3, 3′, 4, 4′-tetrachlorobiphenyl
20. 2+-mediated endonuclease activation
21. The immunological synapse and the actin cytoskeleton: Molecular hardware for T cell signaling
22. The actin cytoskeleton and lymphocyte activation
23. Cytoskeletal rearrangement during migration and activation of T lymphocytes
24. The murine IL-2 promoter contains distal regulatory elements responsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family
25. Dexamethasone, beta-estradiol, and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin elicit thymic atrophy through different cellular targets