Cell-specific expression of the diphtheria toxin A-chain coding sequence induces cancer cell suicide

Chinese Medical Journal

Volumn 115, Issue 6, 2002, Pages 869-873

  Rui, Hongbing ^a   Chen, Yuanzhong ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Diphtheria toxin; Gene therapy; Immunoglobulin light chain

Indexed keywords

BETA GALACTOSIDASE; DIPHTHERIA TOXIN; IMMUNOGLOBULIN KAPPA CHAIN; LIPOSOME; PLASMID DNA;

ALPHA CHAIN; ANIMAL CELL; ANTIBODY PRODUCING CELL; ARTICLE; BACTERIAL GENE; CANCER CELL; CANCER THERAPY; CELL DEATH; CELL GROWTH; CELL LINE; CELL SPECIFICITY; CONTROLLED STUDY; CYTOMEGALOVIRUS; ENHANCER REGION; ENZYME ACTIVITY; GENE CONSTRUCT; GENE CONTROL; GENE EXPRESSION; GENETIC CODE; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROMOTER REGION;

DIPHTHERIA TOXIN; ENHANCER ELEMENTS (GENETICS); GENE THERAPY; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN KAPPA-CHAINS; NEOPLASMS; PEPTIDE FRAGMENTS; PROMOTER REGIONS (GENETICS); TUMOR CELLS, CULTURED;

EID: 0036290816     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Regulated expression of a diphtheria toxin A-chain gene transfected into human cells: Possible strategy for inducing cancer cell suicide
2. Cell-specific expression of the diphtheria toxin A-chain coding sequence under the control of the upstream region of the human alpha-fetoptrotein gene
3. Diphtheria toxin
4. Diphtheria toxin: Mode of action and structure
5. Cell lineage ablation in transgeinc mice by cell-specific expression of a toxin gene
6. Genetic ablation: Programmed lineage suicide by tissue-specific expression of the diphtheria toxin A gene in transgenic mice
7. Expression of the diphtheria toxin A-chain coding sequence under the control of promoters and enhancers from immunoglobulin genes as a means of directing toxicity to B-lymphoid cells
8. Highly efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene
9. Regulated expression of the diphtheria toxin A chain by a tumor-specific chimeric transcription factor results in selective toxicity for alveolar rhabdomyosarcoma cells
10. Targeting and eradicating cancer cells by a prostate-specific vector carrying the diphtheria toxin A gene
11. Cancer gene therapy: Hard lessons and new courses
12. Liposomes in gene therapy
13. Target-cell specificity of fusogenic liposomes: Membrane fusion-mediated macromolecule delivery into human blood mononuclear cells
14. Gene delivery mediated by cationic liposomes: From biophysical aspects to enhancement of transfection