Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit the MEKK1/MEK4/JNK signaling pathway in endotoxin-activated microglia

Biochemical and Biophysical Research Communications

Volumn 293, Issue 2, 2002, Pages 771-776

  Delgado, Mario ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Inflammation; Microglia; Neuroimmunomodulation; Neuropeptides; SAPK JNK

Indexed keywords

CYCLIC AMP; ENDOTOXIN; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; NEUROPEPTIDE; PROTEIN C FOS; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; VASOACTIVE INTESTINAL POLYPEPTIDE;

ARTICLE; CELL ACTIVATION; CENTRAL NERVOUS SYSTEM; ENZYME ACTIVATION; INFLAMMATION; MICROGLIA; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; CYCLIC AMP; ENZYME INHIBITORS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KINETICS; LIPOPOLYSACCHARIDES; MACROPHAGES; MAP KINASE KINASE KINASE 4; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROPEPTIDES; PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTORS, VASOACTIVE INTESTINAL PEPTIDE; RECEPTORS, VASOACTIVE INTESTINAL POLYPEPTIDE, TYPE I; TRANSCRIPTION FACTOR AP-1; VASOACTIVE INTESTINAL PEPTIDE;

EID: 0036290059     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00283-8     Document Type: Article

References (26)

1. Microglia in human disease, with an emphasis on acquired immune deficiency syndrome
2. Immunology of VIP: A review and therapeutical perspectives
3. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit endotoxin-induced TNFα production by macrophages: In vitro and in vivo studies
4. Vasoactive intestinal peptide and pituitary adenylate cyclase activating polypeptide inhibit TNFα transcriptional activation by regulating NF-κB and CREB/c-Jun
5. VIP and PACAP prevent inducible nitric oxide synthase transcription in macrophages by inhibiting NF-κB and interferon regulatory factor 1 activation
6. VIP and PACAP inhibit IL-12 production in LPS-stimulated macrophages. Subsequent effect on IFNγ synthesis by T Cells
7. Inhibition of endotoxin-induced macrophage chemokine production by VIP and PACAP in vitro and in vivo
8. VIP and PACAP protect mice from lethal endotoxemia through the inhibition of TNFα and IL-6
9. Molecules that protect: The defense of neurons and other cells
10. Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia
11. Activation of JNK/SAPK in primary glial cultures: II. Differential activation of kinase isoforms corresponds to their differential expression
12. JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
13. An osmosensing signal transduction pathway in mammalian cells
14. MAP kinase pathways
15. Neuroprotective role of IL-4 against activated microglia
16. Role of SAPK/ERK kinase 1 in the stress-activated pathway regulating transcription factor c-Jun
17. Activation of multiple proline-directed kinases by bacterial lipopolysaccharide in murine macrophages
18. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
19. Phosphorylation of c-Jun mediated by MAP kinases
20. Nomenclature of receptors for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP)
21. In vitro properties of a high affinity selective antagonist of the VIP1 receptor
22. AP-1 function and regulation
23. Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun
24. Jun-B differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers
25. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit interleukin 2 transcription by decreasing c-Jun and increasing Jun-B expression in T cells
26. Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit the MEKK1/MEK4/JNK signaling pathway in LPS-stimulated macrophages