Evaluation of capacity-limited first-pass effect through liver by three-points sampling in portal and hepatic veins and systemic artery

Pharmaceutical Research

Volumn 19, Issue 6, 2002, Pages 852-857

  Ueda, Shinya ^a   Yamaoka, Kiyoshi ^a   Yui, Jyoji ^b   Shigematsu, Akio ^b   Nakagawa, Terumichi ^a  

^a KYOTO UNIVERSITY   (Japan)

^b Institute of Whole Body Metabolism   (Japan)

Author keywords

Capacity limited first pass effect; Hepatic vein sampling; Local disposition; Nonlinear pharmacokinetics

Indexed keywords

FLUOROURACIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISPOSITION; DRUG ELIMINATION; FEMORAL ARTERY; FIRST PASS EFFECT; HEPATIC VEIN; MALE; MICHAELIS CONSTANT; NONHUMAN; NONLINEAR SYSTEM; PORTAL VEIN; PRIORITY JOURNAL; RAT;

EID: 0036288653     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016165101921     Document Type: Article

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