Short-period double-dosing for simultaneous evaluation of intestinal absorption and hepatic disposition in a single conscious rat using cephalexin as test drug

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 12, 1997, Pages 1189-1194

  Ito, Takashi ^a   Yamaoka, Kiyoshi ^a   Nakagawa, Terumichi ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CEFALEXIN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CANNULATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISPOSITION; FEMORAL ARTERY; FLOW MEASUREMENT; INTESTINE ABSORPTION; INTRAARTERIAL DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PORTAL VEIN; PORTAL VEIN BLOOD; PORTAL VEIN BLOOD FLOW; RAT;

EID: 0031453773     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06068.x     Document Type: Article

References (27)

1. Cassidy, M. K., Houston, J. B. (1980) In vivo assessment of extrahepatic conjugative metabolism in first pass effects using the model compound phenol. J. Pharm. Pharmacol. 32: 57-59
2. Daemen, M. J. A. P., Thijssen, H. H. W., van Essen, H., Vervoort-Peters, H. T. M., Prinzen, F. W., Boudier, H. A. J. S., Smits, J. F. M. (1989) Liver blood flow measurement in the rat. J. Pharmacol. Methods 21: 287-297
3. Effeney, D. J., Pond, S. M., Lo, M. W., Silber, B. M., Riegelman, S. (1982) A technique to study hepatic and intestinal drug metabolism separately in the dog. J. Pharmacol. Exp. Ther. 221: 507-511
4. Fujieda, Y., Yamaoka, K., Ito, T., Nakagawa, T. (1996) Local absorption kinetics of levofloxacin from intestinal tract into portal vein in conscious rat using portal-venous concentration difference. Pharm. Res. 13: 1210-1213
5. Gibaldi, M., Perrier, D. (1975) Pharmacokinetics. Marcel Dekker, New York, p. 232
6. Greenblatt, D. J. (1993) Presystemic extraction: mechanisms and consequences. J. Clin. Pharmacol. 33: 650-656
7. Hadengue, A., Lee, S. S., Koshy, A., Girod, C., Lebrec, D. (1988) Regional blood flows by the microsphere method: reproducibility in portal hypertensive rats and influence of a portal vein catheter. Proc. Soc. Exp. Biol. Med. 187: 461-468
8. Harris, P. A., Riegelman, S. (1969) Influence of the route of administration on the area under the plasma concentration-time curve. J. Pharm. Sci. 58: 71-75
9. Hoffman, D. J., Seifert, T., Borre, A., Nellans, H. N. (1995) Method to estimate the rate and extent of intestinal absorption in conscious rats using an absorption probe and portal blood sampling. Pharm. Res. 12: 889-894
10. Lo, M. W., Effeney, D. J., Pond, S. M., Silber, B. M., Riegelman, S. (1982) Lack of gastrointestinal metabolism of propranolol in dogs after portacaval transposition. J. Pharmacol. Exp. Ther. 221: 512-515
11. Nakagawa, T., Haginaka, P., Yamaoka, K., Uno, T. (1978) High speed liquid chromatographic determination of cephalexin in human plasma and urine. J. Antibiot. 31: 769-775
12. Nightingale, C. H., Greene, D. S., Quintiliani, R. (1975) Pharmacokinetics and clinical use of cephalosporin antibiotics. J. Pharm. Sci. 64: 1899-1927
13. Pang, K. S., Gillette, J. R. (1978) Theoretical relationships between area under the curve and route of administration of drugs and their precursors for evaluating sites and pathways of metabolism. J. Pharm. Sci. 67: 703-704
14. Pang, K. S., Cherry, W. F., Ulm, E. H. (1985) Disposition of enalapril in the perfused rat intestine-liver preparation: absorption, metabolism and first-pass effect. J. Pharmacol. Exp. Ther. 233: 788-795
15. Pond, S. M., Tozer, T. N. (1984) First-pass elimination. Basic concepts and clinical consequences. Clin. Pharmacokinet. 9: 1-25
16. Soria, I., Zimmerman, C. L. (1993) Disposition of (-)carbovir in the in situ perfused rat liver and intestinal vasculature preparations. Drug Metab. Dispos. 21: 724-729
17. Souich, P. D., Maurice, H., Heroux, L. (1995) Contribution of the small intestine to the first-pass uptake and systemic clearance of propranolol in rabbits. Drug Metab. Dispos. 23: 279-284
18. 14C in mice and in rats. J. Antibiot. 22: 195-200
19. Tabata, K., Yamaoka, K., Fukuyama, T., Nakagawa, T. (1995) Evaluation of intestinal absorption into the portal system in enterohepatic circulation by measuring the difference in portal-venous blood concentrations of diclofenac. Pharm. Res. 12: 880-883
20. Thummel, K. E., O'Shea, D., Paine, M. F., Shen, D. D., Kunze, K. L., Perkins, J. D., Wilkinson, G. R. (1996) Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism. Clin. Pharmacol. Ther. 59: 491-502
21. Uhing, M. R., Kimura, R. E. (1995a) The effect of surgical bowel manipulation and anaesthesia on intestinal glucose absorption in rats. J. Clin. Invest. 95: 2790-2798
22. Uhing, M. R., Kimura, R. E. (1995b) Active transport of 3-O-methylglucose by the small intestine in chronically catheterized rats. J. Clin. Invest. 95: 2799-2805
23. Wang, S. X., Sutfin, T. A., Baarnhielm, C., Tegardh, C. G. (1989) Contribution of the intestine to the first-pass metabolism of felodipine in the rat. J. Pharmacol. Exp. Ther. 250: 632-636
24. Waynforth, H. B., Flecknell, P. A. (1992) Experimental and Surgical Technique in the Rat. 2nd edn, Academic Press, London, p. 279
25. Wu, C. Y., Benet, L. Z., Hebert, M. F., Gupta, S. K., Rowland, M., Gomez, D. Y., Wacher, V. J. (1995) Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine. Clin. Pharmacol. Ther. 58: 492-497
26. Yano, Y., Yamaoka, K., Yasui, H., Nakagawa, T. (1991) Analysis of arterial-venous blood concentration difference of drugs based on recirculatory theory with fast inverse Laplace transform (FILT). J. Pharmacokin. Biopharm. 19: 71-85
27. Zhong, W. Z., Williams, M. G., Cook, K. J., Van de Giessen, T. L., Jones, B. W., Rousch, K. E. (1994) First-pass effect of cis-3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)benzamide (U-54494) in rats-a model with multiple cannulas for investigation of gastrointestinal and hepatic metabolism. Pharm. Res. 11: 1524-1529