Synthesis and D2-like binding affinity of new derivatives of N-(1-ethyl-2-pyrrolidinylmethyl)-4,5-dihydro-1H-benzo[g]indole-3-carboxamide and related 4H-[1]benzothiopyrano[4,3-b]pyrrole and 5,6-dihydro-4H-benzo[6,7]cyclohepta[b]pyrrole-3-carboxamide analogues

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 8, 2002, Pages 2485-2496

  Pinna, Gérard A ^a   Pirisi, Maria A ^a   Chelucci, Giorgio ^a   Mussinu, Jean M ^a   Murineddu, Gabriele ^a   Loriga, Giovanni ^a   D'Aquila, Paolo S ^a   Serra, Gino ^a  

^a UNIVERSITY OF SASSARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO N (1 ETHYL 2 PYRROLIDINYLMETHYL) 4,5 DIHYDRO 1H BENZO[G]INDOLE 3 CARBOXAMIDE; 2 CHLORO N (1 ETHYL 2 PYRROLIDINYLMETHYL) 5,6 DIHYDRO 4H BENZO[6,7]CYCLOHEPTA[B]PYRROLE 3 CARBOXAMIDE; 6 CHLORO N (1 ETHYL 2 PYRROLIDINYLMETHYL) 4,5 DIHYDRO 1H BENZO[G]INDOLE 3 CARBOXAMIDE; 7 CHLORO N (1 ETHYL 2 PYRROLIDINYLMETHYL) 4,5 DIHYDRO 1H BENZO[G]INDOLE 3 CARBOXAMIDE; 7,8 DICHLORO N (1 ETHYL 2 PYRROLIDINYLMETHYL) 4,5 DIHYDRO 1H BENZO[G]INDOLE 3 CARBOXAMIDE; 8 CHLORO N (1 ETHYL 2 PYRROLIDINYLMETHYL) 4,5 DIHYDRO 1H BENZO[G]INDOLE 3 CARBOXAMIDE; AMIDE; AMPHETAMINE; DOPAMINE 2 RECEPTOR; N (1 ETHYL 2 PYRROLIDINYLMETHYL) 4,5 DIHYDRO 7 METHOXY 1H BENZO[G]INDOLE 3 CARBOXAMIDE; N (1 ETHYL 2 PYRROLIDINYLMETHYL) 4,5 DIHYDRO 8 METHYL 1H BENZO[G]INDOLE 3 CARBOXAMIDE; N (1 ETHYL 2 PYRROLIDINYLMETHYL) 4H [1]BENZOTHIOPYRANO[4,3 B]PYRROLE 1 CARBOXAMIDE; N (1 ETHYL 2 PYRROLIDINYLMETHYL) 5,6 DIHYDRO 4H BENZO[6,7]CYCLOHEPTA[B]PYRROLE 3 CARBOXAMIDE; NEUROLEPTIC AGENT; UNCLASSIFIED DRUG; DOPAMINE 1 RECEPTOR; INDOLE DERIVATIVE; PYRROLE DERIVATIVE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATALEPSY; CAUDATE NUCLEUS; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; HYPERACTIVITY; MALE; NONHUMAN; PHYSICAL CHEMISTRY; RAT; RECEPTOR AFFINITY; ANIMAL; METABOLISM; PROTEIN BINDING; RESTLESSNESS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMIDES; AMPHETAMINE; ANIMALS; ANTIPSYCHOTIC AGENTS; INDOLES; PROTEIN BINDING; PSYCHOMOTOR AGITATION; PYRROLES; RATS; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036286614     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00118-9     Document Type: Article

References (19)

1. Statistical Principles in Experimental Design