CTLA-4 49 A/G dimorphism and type 1 diabetes susceptibility: A French case-control study and segregation analysis. Evidence of a maternal effect

European Journal of Immunogenetics

Volumn 29, Issue 3, 2002, Pages 251-257

  Fajardy, I ^a   Vambergue, A ^a   Stuckens, C ^a   Weill, J ^a   Danze, P M ^a   Fontaine, P ^a  

^a LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA DR ANTIGEN; ADENINE; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4; DIFFERENTIATION ANTIGEN; GUANINE; LEUKOCYTE ANTIGEN;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MEIOSIS; PLACENTAL TRANSFER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGENY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEGREGATION ANALYSIS; VARIABLE NUMBER OF TANDEM REPEAT; CASE CONTROL STUDY; FRANCE; GENETICS; GENOME IMPRINTING; PRESCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

ADENINE; ADOLESCENT; ADULT; AGED; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; FRANCE; GENE FREQUENCY; GENOMIC IMPRINTING; GUANINE; HUMANS; MALE; MINISATELLITE REPEATS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 0036281953     PISSN: 09607420     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2370.2002.00309.x     Document Type: Article

References (34)

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3. A new member of the immunoglobulin superfamily CTLA-4
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5. An improved strategy for HLA-DRB1 subtyping by digestion of PCR-am plified DNA with allele specific restriction endonucleases
6. Increased risk of insulin-dependent diabetes for siblings of diabetic children with the DR3 haplotype of the mother
7. No major role for the CTLA-4 gene in the association of autoimmune thyroid disease with IDDM
8. CTLA-4 gene polymorphism is associated with predisposition to coeliac disease
9. Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease
10. CTLA-4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus
11. CTLA-4 gene haplotypes cannot protect from IDDM in the presence of high-risk HLA DQ8 or DQ2 alleles in German families
12. HLA-DRB1*04 and susceptibility to type 1 diabetes mellitus in a German/Belgian family and German case-control study
13. CTLA-4 promoter and exon 1 dimorphisms in multiple sclerosis
14. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q
15. CD28/CTLA-4 gene region on chromosome 2q33 confers genetic susceptibility to celiac disease. A linkage and family-based association study
16. Genetic association of CTLA-4 to myasthenia gravis with thymoma
17. Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility
18. ACTLA-4 gene polymorphism is associated with both Graves disease and autoimmune hypothyroidism
19. CTLA-4 gene polymorphism is associated with predisposition to IDDM in a population from central Poland
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21. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA-4 polymorphisms in multiple ethnic groups
22. Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33
23. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes
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25. The search for type I diabetes susceptibility genes; the next generation
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27. CTLA-4 codon 17 dimorphism in patients with rheumatoid arthritis
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29. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
30. Preferential transmission of diabetic alleles within the HLA gene complex
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32. CTLA-4 gene polymorphism confers susceptibility to insulin-dependent diabetes mellitus (IDDM) independently from age and from other genetic or immune disease markers
33. CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population