Characterization, heterologous expression and functional analysis of mevalonate diphosphate decarboxylase gene (MVD) of Candida albicans

Molecular Genetics and Genomics

Volumn 267, Issue 3, 2002, Pages 281-290

  Dassanayake, R ^a   Cao, L ^b   Samaranayake, L ^a   Berges, T ^c  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c IBMIG Institut de Biologie Moleculaire et dIngenierie Genetique   (France)

Author keywords

Candida albicans; Complementation; Mevalonate diphosphate decarboxylase; Saccharomyces cerevisiae

Indexed keywords

AMINO ACID; CARBOXYLYASE; GENOMIC DNA; MEVALONATE DIPHOSPHATE DECARBOXYLASE; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; ARTICLE; CANDIDA ALBICANS; CHROMOSOMAL LOCALIZATION; CHROMOSOME 1; CONTROLLED STUDY; FUNGUS GROWTH; GENE ACTIVITY; GENE CONTROL; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE LOCATION; GENE SEQUENCE; GENETIC CODE; GENETIC COMPLEMENTATION; GROWTH CURVE; INTRON; KARYOTYPE; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; NORTHERN BLOTTING; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PULSED FIELD GEL ELECTROPHORESIS; SACCHAROMYCES CEREVISIAE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SOUTHERN BLOTTING;

CANDIDA; CANDIDA ALBICANS; FUNGI; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0036273913     PISSN: 16174615     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00438-002-0648-7     Document Type: Article

References (53)

1. Positive and negative regulation of a sterol biosynthetic gene (ERG3) in the post-squalene portion of the yeast ergosterol pathway
2. Genome-wide expression patterns in Saccharomyces cerevisiae: Comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol
3. Cloning of a Candida albicans peptide transport gene
4. Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-methylglutaryl-coenzyme A reductase
5. Genetic dissimilarity of two fluconazole-resistant Candida albicans strains causing meningitis and oral candidiasis in the same AIDS patient
6. Synthetic lethality with fibrillarin identifies NOP77, a nucleolar protein required for pre-rRNA processing and modification
7. Characterisation of a Leuto-Pro mutation in a conserved sequence of mevalonate diphosphate decarboxylase in yeast
8. Cat8p, the activator of gluconeogenic genes in Saccharomyces cerevisiae, regulates carbon source-dependent expression of NADP-dependent cytosolic isocitrate dehydrogenase (Idp2p) and lactate permease (Jen1p)
9. Control of filament formation in Candida albicans by the transcriptional repressor TUP1
10. A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae
11. MPI encodes an abundant and highly antigenic cell wall mannoprotein in the pathogenic fungus Penicillium marneffei
12. Constitutive and carbon source-responsive promoter elements are involved in the regulated expression of the Saccharomyces cerevisiae malate synthase gene MLS1
13. Effect of phenylalanine derivatives on the main regulatory enzymes of hepatic cholesterogenesis
14. Biochemistry and molecular biology of the isoprenoid biosynthetic pathway in plants
15. Heterologous expression in Saccharomyces cerevisiae of an Arabidopsis thaliana cDNA encoding mevalonate diphosphate decarboxylase
16. The Saccharomyces cerevisiae mevalonate diphosphate decarboxylase (Erg19p) forms homodimers in vivo, and a single substitution in a structurally conserved region impairs dimerization
17. Inhibition by 6-fluoromevalonate demonstrates that mevalonate or one of the mevalonate phosphates is necessary for lymphocyte proliferation
18. Suppression of the proliferation of Ras-transformed cells by fluoromevalonate, an inhibitor of mevalonate metabolism
19. Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae
20. Genomic profiling of the response of Candida albicans to itraconazole treatment using a DNA microarray
21. Characterization and regulation of the genes encoding ribosomal proteins L39 and S7 of the human pathogen Candida albicans
22. Candida species
23. Antifungal drugs
24. Regulation of the mevalonate pathway
25. A hyphal-specific chitin synthase gene (CHS2) is not essential for growth, dimorphism, or virulence of Candida albicans
26. Purification of NSP1 reveals complex formation with "GLFG" nucleoporins and a novel nuclear pore proteins NIC96
27. 3'-End-forming signals of yeast. mRNA
28. Physiological aspects and mechanism of action of mevalonate 5-diphosphate decarboxylase
29. Cloning and characterization of the 2,3-oxidosqualene cyclase-coding gene of Candida albicans
30. Transcriptional regulation of the squalene synthase gene (ERG9) in the yeast Saccharomyces cerevisiae
31. Over-expression of a cloned IMP dehydrogenase gene confers resistance to the specific inhibitor mycophenolic acid
32. Antifungal agents
33. Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae
34. Oral colonization, phenotypic and genotypic profiles of Candida species in irradiated, dentate, xerostomic nasopharyngeal carcinoma survivors
35. Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homolog
36. Sequence of the Candida albicans gene encoding actin
37. Assignment of cloned genes to the seven electrophoretically separated Candida albicans chromosomes
38. A sequence pattern that occurs at the transcription initiation region of yeast RNA polymerase II promoters
39. Molecular cloning and characterization of a Candida albicans gene (EFB1) coding for the elongation factor EF-1 beta
40. Development of fluconazole resistance in Candida albicans causing disseminated infection in a patient undergoing marrow transplantation
41. Translation elongation factor 2 is encoded by a single essential gene in Candida albicans
42. Lower mevalonate pyrophosphate decarboxylase activity is caused by the reduced amount of enzyme in stroke-prone spontaneously hypertensive rat
43. Inhibition of cholesterol biosynthesis by fluorinated mevalonate analogues
44. The isolation and characterization of a calmodulin-encoding gene (CMDI) front the dimorphic fungus Candida albicans
45. Requirement of home to replace the sparking sterol function in the yeast Saccharomyces cerevisiae
46. Protein A-calmodulin fusions: A novel approach for investigating calmodulin function in yeast
47. Conservation of eukaryotic sterol homeostasis: New insights from studies in budding yeast
48. Systematic determination of genetic network architecture
49. Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase
50. Elevated phenotypic switching and drug resistance of Candida albicans from human immunodeficiency virus-positive individuals prior to first thrush episode
51. Candida species: Emerging hospital bloodstream pathogens
52. Infections due to resistant Candida species in patients with cancer who are receiving chemotherapy