On the scientific and ethical issues of fetal somatic gene therapy

Gene Therapy

Volumn 9, Issue 11, 2002, Pages 670-673

  Coutelle, C ^a   Rodeck, C ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

Ethics; Fetal in utero gene therapy

Indexed keywords

BLOOD CLOTTING FACTOR 9;

ABORTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA MODIFICATION; DNA VECTOR; FETUS; GENE THERAPY; GENETIC SELECTION; GERM LINE; HYPOTHESIS; MEDICAL DECISION MAKING; MEDICAL ETHICS; MOUSE; NIDATION; NONHUMAN; POSTNATAL CARE; PREIMPLANTATION EMBRYO; PRENATAL PERIOD; PRIORITY JOURNAL; RISK ASSESSMENT; TREATMENT PLANNING;

GENETICS AND REPRODUCTION;

ABORTION, THERAPEUTIC; ANIMALS; ETHICS, MEDICAL; FEMALE; FETAL DISEASES; GENE THERAPY; GENETIC VECTORS; HUMANS; MICE; MODELS, ANIMAL; PREGNANCY; SHEEP;

ANIMALIA;

EID: 0036272667     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301761     Document Type: Article

References (14)

1. The challenge of fetal gene therapy
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3. Towards an ovine model of cystic fibrosis
4. Gene transfer into the fetal primate: Evidence for the secretion of transgene product
5. Rhesus monkey model for fetal gene transfer: Studies with retroviral- based vector systems
6. In utero gene delivery by intraamniotic injection of a retroviral vector producer cell line in a nonhuman primate model
7. Foetal gene delivery in mice by intra-amniotic administration of retroviral producer cells and adenovirus
8. Therapeutic concentrations of human factor IX in mice after gene delivery into the amniotic cavity: A model for the prenatal treatment of haemophilia B
9. Sustained delivery of therapeutic concentrations of human clotting factor IX - A comparison of adenoviral and AAV vectors administered in utero
10. High level expression of β-galactosidase and factor IX transgenes in fetal and neonatal sheep after ultrasound-guided transcutaneous adenovirus vector administration into the umbilical vein
11. Effect of amniotic fluid on cationic lipid mediated transfection and viral infection
12. In utero gene therapy: Transfer and long-term expression of the bacterial neo(r) gene in sheep after direct injection of retroviral vectors into preimmune fetuses
13. An estimated frequency of endogenous insertional mutations in humans
14. Human fetal gene therapy: Moral and ethical questions