CC chemokine receptor 4 as a possible target for therapy of atopic dermatitis

Drug News and Perspectives

Volumn 15, Issue 3, 2002, Pages 175-179

  Wakugawa, Motoshi ^a   Nakamura, Koichiro ^a   Kakinuma, Takashi ^a   Tamaki, Kunihiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR4; THYMUS AND ACTIVATION REGULATED CHEMOKINE;

ATOPIC DERMATITIS; CELL ACTIVATION; CELL INFILTRATION; CELL POLARITY; PATHOGENESIS; REVIEW; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

EID: 0036271104     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2002.15.3.704686     Document Type: Review

References (31)

1. Topical tacrolimus (FK 506): A new milestone in the management of atopic dermatitis
2. Ascomycin: An advance in the management of atopic dermatitis
3. Decreased level of ceramides in stratum corneum of atopic dermatitis: An etiologic factor in atopic dry skin?
4. Skinderived aeroallergen-specific T-cell clones of Th2 phenotype in patients with atopic dermatitis
5. Differential cytokine profiles in peripheral blood lymphocyte supernatants and skin biopsies from patients with different forms of atopic dermatitis, psoriasis and normal individuals
6. Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis
7. Biomolecular regulation of the IgE immune response. II. In vitro IgE synthesis and spontaneous production of cytokines
8. Lesional expression of interferon-gamma in atopic eczema
9. Analysis of the cytokine pattern expressed in situ in inhalant allergen patch test reactions of atopic dermatitis patients
10. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: An immunocytochemical study
11. Chemokines and leukocyte traffic
12. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s
13. CCR5 is characteristic of Th1 lymphocytes
14. Chemokine and chemokine receptors in T-cell priming and Th1/Th2-mediated response
15. TCR-mediated activation of allergen-specific CD45RO(+) memory T lymphocytes results in down-regulation of cell-surface CXCR4 expression and a strongly reduced capacity to migrate in response to stromal cell-derived factor-1
16. Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells
17. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
18. CC chemokine receptor 4 expression on peripheral blood CD4+ T cells reflects disease activity of atopic dermatitis
19. Elevated levels of interleukin 2 receptor in sera of patients with atopic dermatitis and psoriasis
20. Serum soluble IL2 receptor (sIL-2R) and eosinophil cationic protein (ECP) levels in atopic dermatitis
21. Atopic dermatitis: Correlation of peripheral blood T cell activation, eosinophilia and serum factors with clinical severity
22. Differential expression of the chemokine receptors by the Th1- and Th2-type effector populations within circulating CD4+ T cells
23. Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions
24. Thymus and activation-regulated chemokine (TARC) in atopic dermatitis: Serum TARC levels is closely related with disease activity
25. IL-10 augments the IFN-gamma and TNF-alpha induced TARC production in HaCaT cells: A possible mechanism in the inflammatory reaction of atopic dermatitis
26. Recombinant interferon gamma therapy for atopic dermatitis
27. Recombinant interferon gamma in severe atopic dermatitis
28. Intervention of thymus and activation regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice
29. A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock
30. Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice
31. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2