Simultaneous measurement of serum thrombopoietin and expression of megakaryocyte c-Mpl with clinical and laboratory correlates for Myelofibrosis with Myeloid Metaplasia

European Journal of Haematology

Volumn 68, Issue 3, 2002, Pages 175-179

  Elliott, Michelle A ^a   Yoon, Soo Young ^a   Kao, Pai ^a   Li, Chin Yang ^a   Tefferi, Ayalew ^a  

^a MAYO CLINIC   (United States)

Author keywords

Megakaryocytes; Myelofibrosis; Myeloid metaplasia; Platelet count; Thrombopoietin

Indexed keywords

MONOCLONAL ANTIBODY; THROMBOPOIETIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; FEMALE; HEMATOLOGICAL PARAMETERS; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MYELOFIBROSIS; MYELOID METAPLASIA; PRIORITY JOURNAL; THROMBOCYTE COUNT;

ADULT; AGED; BONE MARROW CELLS; CELL COUNT; CHEMILUMINESCENT MEASUREMENTS; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOASSAY; IMMUNOENZYME TECHNIQUES; IMMUNOHISTOCHEMISTRY; MALE; MEGAKARYOCYTES; MIDDLE AGED; MYELOFIBROSIS; MYELOID METAPLASIA; NEOPLASM PROTEINS; PLATELET COUNT; PROTO-ONCOGENE PROTEINS; RECEPTORS, CYTOKINE; RECEPTORS, THROMBOPOIETIN; SPLEEN; THROMBOPOIETIN;

EID: 0036269583     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0609.2002.01534.x     Document Type: Article

References (14)

1. Thrombopoietin and the hematopoietic stem cell
2. Human platelets as a model for the binding and degradation of thrombopoietin
3. Interaction of thrombopoietin with the platelet c-mpl receptor in plasma: Binding, internalization, stability and pharmacokinetics
4. A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): Reversal of disease by bone marrow transplantation
5. Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily
6. Impaired expression of the thombopoietin receptor by platelets from patients with polycythemia vera
7. Post-translational processing of the thrombopoietin receptor is impaired in polycythemia vera
8. Immunohistochemical staining for megakaryocyte c-mpl may complement morphologic distinction between polycythemia vera and secondary crythrocytosis
9. Blood thrombopoietin, IL-6 and IL-11 levels in patients with agnogenic myeloid metaplasia
10. Polycythaemia vera and myelosclerosis: A bone marrow study
11. The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit
12. Hydroxyurea-induced marked oscillations of platelet counts in patients with polycythemia vera
13. Transforming growth factor-beta 1 (TGF-beta-1) induces thrombopoietin from bone marrow stromal cells, which stimulates the expression of TGF-beta receptor on megakaryocytes and, in turn, renders them susceptible to suppression by TGF-beta itself with high specificity
14. Autonomous megakaryocyte growth in essential thrombocythemia and idiopathic myelofibrosis is not related to a c-mpl mutation or to an autocrine stimulation by Mpl-L