Development of plasmid and oligonucleotide nanometric particles

Gene Therapy

Volumn 9, Issue 11, 2002, Pages 743-748

  Dauty, E ^a   Behr, J P ^a   Remy, J S ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Cationic detergent; DNA condensation; Gene delivery; Oligonucleotide; Poly(ethylene glycol)

Indexed keywords

ANION; CATION; CELL SURFACE RECEPTOR; DETERGENT; LIPID; MACROGOL; OLIGONUCLEOTIDE; PLASMID DNA; PROTEOHEPARAN SULFATE; THIOL DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL LINE; CELL NUCLEUS; COMPLEX FORMATION; CONTROLLED STUDY; DIMERIZATION; DISULFIDE BOND; DNA TEMPLATE; DNA VECTOR; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG SYNTHESIS; DRUG TRANSPORT; ELECTROPHORETIC MOBILITY; FIBROBLAST; GEL ELECTROPHORESIS; INTRACELLULAR TRANSPORT; KIDNEY CELL; LIVER CELL; MATERIAL COATING; MOLECULAR SIZE; MOLECULAR STABILITY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NUCLEAR PORE COMPLEX; PARTICLE SIZE; PLASMID; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

BIOLOGICAL TRANSPORT; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; NANOTECHNOLOGY; OLIGONUCLEOTIDES; PLASMIDS;

ANIMALIA;

EID: 0036268306     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301759     Document Type: Article

References (19)

1. Size-dependent DNA mobility in cytoplasm and nucleus
2. Signal-mediated nuclear transport in proliferating and growth-arrested BALB/c 3T3 cells
3. The influence of polymer structure on the interactions of cationic polymers with DNA and morphology of the resulting complexes
4. DNA strongly binds to micelles and vesicles containing lipopolyamines or lipointercalants
5. Discrete coil-globule transition of large DNA induced by cationic surfactant
6. Gene transfer with a series of lipophilic DNA-binding molecules
7. Gene transfer by cationic surfactants is essentially limited by the trapping of the surfactant/DNA complexes onto the cell membrane: A fluorescence investigation
8. Template oligomerization of DNA-bound cations produces calibrated nanometric particles
9. Monomolecular collapse of plasmid DNA into stable virus-like particles
10. Dimerizable cationic detergents with a low cmc condense plasmid DNA into nanometric particles and transfect cells in culture
11. An electron microscopy study into the mechanism of gene transfer with lipopolyamines
12. Evidence for the role of proteoglycans in cation-mediated gene transfer
13. Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA
14. Optimized galenics improve in vitro gene transfer with cationic molecules up to thousand-fold
15. Sterically stabilized liposomes
16. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo
17. Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery
18. PEGylated DNA/transferrin-PEI complexes: Reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery
19. In vitro gene delivery to hepatocytes with galactosylated polyethylenimine