The enteropathy of celiac disease

Journal of Pediatric Gastroenterology and Nutrition

Volumn 34, Issue SUPPL. 1, 2002, Pages

  Lionetti, Paolo ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD94 ANTIGEN; CYTOKINE; GAMMA INTERFERON; HLA ANTIGEN CLASS 2; HLA DP ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 8; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; CELIAC DISEASE; CONFERENCE PAPER; CYTOKINE RELEASE; ENTEROPATHY; HUMAN; INTESTINE EPITHELIUM; LAMINA PROPRIA; PRIORITY JOURNAL; T LYMPHOCYTE;

CELIAC DISEASE; CHILD; CHILD DEVELOPMENT; HUMANS; INTESTINAL MUCOSA; INTESTINE, SMALL; LYMPHOCYTES;

EID: 0036266302     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005176-200205001-00005     Document Type: Conference Paper

References (50)

1. Observations on the aetiology of idiopathic steatorrhoea
2. Coeliac disease with atrophy of the small intestine mucosa
3. Coeliac disease
4. Intraepithelial lymphocytes of the small intestine
5. Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiological approach to the spectrum of gluten sensitivity ("coeliac sprue")
6. Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in celiac disease
7. Increased jejunal intraepithelial lymphocytes bearing γ/δ T-cell receptor in dermatitis herpetiformis
8. Intraepithelial γ/δ T-cell-receptor lymphocytes and genetic susceptibility to celiac disease
9. Increase in γ/δ T cell receptor bearing lymphocytes in normal small bowel mucosa in latent celiac disease
10. Ulceration of the small intestine in children with coeliac disease
11. Morphometric analysis of small intestinal mucosa II. Determination of lamina propria volumes, plasma cell and neutrophil populations within control and coeliac disease mucosa
12. Epithelial-cell renewal in cultured duodenal biopsies in coeliac sprue
13. Cell kinetics in flat (avillous) mucosa of the human small intestine
14. The use of a stathmokinetic technique with crypt microdissection to estimate the crypt cell production rate in cultured explants of the duodenal mucosa in coeliac disease
15. Novel insights into human intestinal epithelial cell proliferation in health and disease using confocal microscopy
16. Celiac disease: A study of the jejunal epithelium before and after a gluten-free diet
17. Expression of major histocompatibility complex class II subregion product by jejunal epithelium in patients with celiac disease
18. HLA-DR DP and DQ expression in the small intestine of patients with coeliac disease
19. Fibroblasts and transforming growth factor β induce organization and differentiation of T84 human epithelial cells
20. Differing patterns of transforming growth factor β expression in normal intestinal mucosa and in active celiac disease
21. Increased small intestinal apoptosis in coeliac disease
22. Specificity of ultrastructural changes of small intestinal epithelium in early childhood
23. Selective alteration of brush-border hydrolyses in intestinal disease in childhood
24. Intestinal proliferation in coeliac disease: Looking into the crypt
25. Triggered human mucosal T cells release tumour necrosis factor-alpha and interferon-gamma which kill human colonic epithelial cells
26. T cells orchestrate intestinal mucosal shape and integrity
27. T-cell activation can induce either mucosal destruction or adaptation in cultured human fetal small intestine
28. Interaction between stromal cell-derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia
29. A major role of matrix metalloproteinases in T cell injury in the gut
30. Interleukin 15 mediates epithelial changes in celiac disease
31. Numbers of T cell receptor TCR αβ+ but not of TcR γδ + intraepithelial lymphocytes correlate with the grade of villous atrophy in coeliac patients on a long term normal diet
32. Activated T lymphocytes in celiac lesion: Non-proliferative activation (CD25) of CD4+ αβ cells in the lamina propria but proliferation (Ki-67) of αβ and γ/δ cells in the epithelium
33. + phenotypes are increased in coeliac disease
34. Expression of disulphide-linked and non-disulphide-linked forms of the T cell receptor γ/δ heterodimer in human intestinal intraepithelial lymphocytes
35. Recognition of stress-induced MHC molecules by intestinal epithelial γ/δ T cells
36. Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions
37. Evidence that intestinal intraepithelial lymphocytes are activated cytotoxic T cells in celiac disease but not in giardiasis
38. Selective expansion of intraepithelial lymphocytes expressing the HLA-E-specific natural killer receptor CD94 in celiac disease
39. Expression of major histocompatibility complex class II subregion products by jejunal epithelium in patients with coeliac disease
40. Differential upregulation of intercellular adhesion molecule-1 in coeliac disease
41. Intrepithelial TcRαβ+ lymphocytes express CD45RO more often than the TcRγδ+ counterparts in celiac disease
42. Gliadin-specific, HLA-DQ (al*0501,bl*0201) restricted T cells isolated from the small intestinal mucosa of celiac disease patients
43. T cells from the small intestinal mucosa of a DR4, DQ7/DR4, DQ8 celiac disease patient preferentially recognize gliadin when presented by DQ8
44. Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease
45. Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity
46. Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th 1 or ThO profile dominated by interferon γ
47. Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease
48. Mucosal interferon gamma production in latent-potential celiac disease
49. Role of interferon α in promoting T helper cell type 1 responses in the small intestine in celiac disease
50. Increased expression of mRNA for matrix metalloproteinase-1 and -3 and tissue inhibitor of metalloproteinases-1 in intestinal biopsy specimens from patients with coeliac disease