Antagonism of activin by inhibin and inhibin receptors: A functional role for betaglycan-glycan

Molecular and Cellular Endocrinology

Volumn 180, Issue 1-2, 2001, Pages 47-53

  Gray, Peter C ^a   Bilezikjian, Louise M ^a   Vale, Wylie ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Activin; Betaglycan; Follistatin; Inhibin; Receptor, (pituitary, gonadotrope)

Indexed keywords

ACTIVIN; ACTIVIN A; FOLLISTATIN; GLYCAN; GLYCAN DERIVATIVE; INHIBIN; INHIBIN A; RECEPTOR;

ANIMAL CELL; CONFERENCE PAPER; DRUG ANTAGONISM; HUMAN; HYPOPHYSIS; MODEL; NONHUMAN; PRIORITY JOURNAL;

ACTIVIN RECEPTORS; ACTIVINS; ANIMALS; HUMANS; INHIBINS; PITUITARY GLAND; PROTEOGLYCANS; RECEPTORS, PEPTIDE; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA;

EID: 0035974481     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(01)00515-9     Document Type: Conference Paper

References (88)

1. Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members
2. Role of activin and other peptide growth factors in body patterning in the early amphibian embryo
3. Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors
4. Activation of signaling by the activin receptor complex
5. Activin-A inhibits proopiomelanocortin messenger RNA accumulation and adrenocorticotropin secretion of AtT20 cells
6. Activin-A regulates follistatin secretion from cultured rat anterior pituitary cells
7. Characterization and the regulation of inhibin/activin subunit proteins of cultured rat anterior pituitary cells
8. Pituitary follistatin and inhibin subunit mRNA levels are differentially regulated by local and hormonal factors
9. Inhibition of somatotroph growth and GH biosynthesis by activin in vitro
10. A large domain common to sperm receptors (Zp2 and Zp3) and TGF-beta type III receptor
11. Requirement of type III TGF-beta receptor for endocardial cell transformation in the heart
12. Selective and indirect modulation of human multipotential and erythroid hematopoietc progenitor cell proliferation by recombinant human activin and inhibin
13. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin
14. Transforming growth factor-beta (TGF-beta) receptor proteoglycan. Cell surface expression and ligand binding in the absence of glycosaminoglycan chains
15. Isoform-specific transforming growth factor-beta binding proteins with membrane attachments sensitive to phosphatidylinositol-specific phospholipase C
16. The transforming growth factor-beta system, a complex pattern of cross-reactive ligands and receptors
17. The transforming growth factor-B receptor type III is a membrane proteoglycan
18. Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to 3 TGF-beta isoforms
19. Endoglin is a component of the transforming growth factor-p receptor system in human endothelial cells
20. Structure and expression of a membrane component of the inhibin receptor system
21. Evidence for an autocrine role of activin B within rat anterior pituitary cultures
22. Gonadotropin-releasing hormone regulation of gonadotropin subunit gene expression in female rats: actions on follicle-stimulating hormone Betaglycan messenger ribonucleic acid (mRNA) involve differential expression of pituitary activin (Betaglycan-B) and follistatin mRNAS
23. TGF-beta receptor signaling
24. Identification of an inhibin receptor in gonadal tumors from inhibin alpha-subunit knockout mice
25. Purification and characterization of erythroid differentiation factor (EDF) isolated from human leukemia cell line THP-1
26. Activins and the receptor serine kinase superfamily
27. Activin-A modulates gonadotropin-releasing hormone secretion from a gonadotropin-releasing hormone-secreting neuronal cell line
28. Pituitary follicular cells secrete both vascular endothelial growth factor and follistatin
29. Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells
30. Identification of a binding site on the type II activin receptor for activin and inhibin
31. Identification of high affinity binding sites for inhibin on ovine pituitary cells in culture
32. Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells
33. The roles of inhibin and related peptides in gonadal function
34. Gonadotropin-releasing hormone pulse frequency regulates expression of pituitary follistatin messenger ribonucleic acid: a mechanism for differential gonadotrope function
35. Activin-A: a modulator of multiple types of anterior pituitary cells
36. Localization of inhibin and activin binding sites in the testis during development by in situ ligand binding
37. Activin and inhibin have antagonistic effects on ligand-dependent heterodimerization of the type I and type II activin receptors and human erythroid differentiation
38. Roles of pathway-specific and inhibitory Smads in activin receptor signaling
39. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
40. r 32,000 protein with inhibin activity from porcine follicular fluid
41. A homodimer of the beta-subunits of inhibin A stimulates the secretion of pituitary follicle stimulating hormone
42. Pituitary FSH is released by a heterodimer of the P-subunits from the two forms of inhibin
43. Structure and expression of the membrane proteoglycanBetaglycan, a component of the TGF-beta receptor system
44. Betaglycan presents ligand to the TGF beta signaling receptor
45. Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites
46. Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells
47. Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-beta
48. The transforming growth factor-Betaglycan family
49. TGF-beta signal transduction
50. Expression cloning of an activin receptor, a predicted transmembrane serine kinase
51. Cloning of a second type of activin receptor and functional characterization in Xenopus embryos
52. Inhibin-α is a tumour-suppressor gene with gonadal specificity in mice
53. Transgenic models to study the roles of inhibins and activins in reproduction, oncogenesis, and development
54. Inhibin α-subunit cDNAs from porcine ovary and human placenta
55. Dual endocrine activity of the testes
56. Isolation of porcine follicular fluid inhibin of 32K daltons
57. The transforming growth factor beta receptors types I, II, and III form hetero-oligomeric complexes in the presence of ligand
58. A novel role for activin in inflammation and repair
59. Transforming growth factor-beta and activin inhibit basal secretion of prolactin in a pituitary monolayer culture system
60. Activin-binding protein from rat ovary is follistatin
61. Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
62. Bovine bone activin enhances bone morphogenetic protein-induced ectopic bone formation
63. Effect of local injection of activin A on bone formation in newborn rats
64. Activin signal transduction pathways
65. Activins and their receptors in female reproduction
66. Central activin administration modulates corticotropin-releasing hormone and adrenocorticotropin secretion
67. Role of activins in the male reproductive tract
68. Purification and partial characterization of inhibin from porcine follicular fluid
69. Production and regulation of inhibin subunits in pituitary gonadotropes
70. Hybridization histochemical and immunohistochemical localization of inhibin/activin subunits and messenger ribonucleic acids in the rat brain
71. Isolation of inhibin from bovine follicular fluid
72. Expression of transforming growth factor type III receptor in vascular endothelial cells increases their responsiveness to transforming growth factor beta 2
73. Inhibinin central neural pathways involved in the control of oxytocin secretion
74. Activin is a nerve cell survival molecule
75. The high molecular weight receptor to transforming growth factor-Betaglycan contains glycosaminoglycan chains
76. Binding of transforming growth factor-beta to cell surface proteins varies with cell type
77. Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A
78. r 35,000 monomeric protein that inhibits the release of follicle stimulating hormone
79. Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid
80. Expression cloning and characterization of the TGF-beta type III receptor
81. In situ ligand binding of recombinant human [1-125]Activin-A and recombinant human [I-125]Inhibin-A to the adult rat ovary
82. The Smad pathway
83. Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism
84. Activins and activin receptors in cell growth
85. The role of FSH releasing protein and inhibin in erythrodifferentiation
86. Amino acid determinants that drive heparan sulfate assembly in a proteoglycan