Gene therapy for diabetic rats by electroporational transfer of naked plasmid with human pre-pro-insulin gene into skeletal muscle

Biotechnology Letters

Volumn 24, Issue 10, 2002, Pages 851-855

  Yang, Ji Chun ^a   Liu, Jian ^b   Yang, Xing Wen ^a   Tang, Jian Guo ^a  

^a PEKING UNIVERSITY   (China)

^b Peking Union University   (China)

Author keywords

Blood glucose; Diabetes mellitus; Electroporation; Gene therapy; Insulin like protein

Indexed keywords

GLUCOSE; INSULIN LIKE PROTEIN; PREPROINSULIN; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; ELECTROPORATION; GENE EXPRESSION; GENE THERAPY; GENE TRANSFER; GLUCOSE BLOOD LEVEL; MALE; NONHUMAN; PLASMID; RAT; SKELETAL MUSCLE;

ANIMALIA;

EID: 0036260261     PISSN: 01415492     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1015506822817     Document Type: Article

References (19)

1. Toward engineering skeletal muscle to release peptide hormone from the human pre-proinsulin gene
2. Neonatal treatment with beta-cell stimulatory agents reduces the incidence of diabetes in BB rats
3. Integrating retroviral cassette extends gene delivery of HSV-1 expression vectors to dividing cells
4. Hepatic insulin expression improves glycemic control in type 1 diabetic rats
5. Efficiency of in vivo gene transfer using murine retroviral vectors is strain-dependent in mice
6. Glucose control and long-term survival in biobreeding/Worcester rats after intraperitoneal implantation of hydrophilic macrobeads containing porcine islets without immunosuppression
7. Naked plasmid-mediated gene transfer to skeletal muscle ameliorates diabetes mellitus
8. Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogue
9. Optimisation of electrotransfer of plasmid into skeletal muscle by pretreatment with hyaluronidase - Increased expression with reduced muscle damage
10. High-efficiency gene transfer into skeletal muscle mediated by electric pulses
11. In vivo gene electroporation in skeletal muscle with special reference to the duration of gene expression
12. Comparison of three nonviral transfection methods for foreign gene expression in early chicken embryos in ovo
13. A novel non-viral gene transfer system, polycation liposomes
14. Adenovirus-mediated transfer of a human dystrophin gene to skeletal muscle of mdx mouse
15. Viral vectors for gene therapy
16. Reversal of diabetes in streptozotocin-treated rats by intramuscular injection of recombinant adeno-associated virus containing rat preproinsulin II gene
17. Direct gene transfer into rat liver cells by in vivo electroporation
18. Efficient long-term gene transfer into muscle tissue of immunocompetent mice by adeno-associated virus vector
19. Gene therapy for streptozotocin-induced diabetic mice by electroporational transfer of naked human insulin precursor DNA into skeletal muscle in vivo