Adenosine production and its role in protection against ischemic and reperfusion injury of the myocardium

Folia Pharmacologica Japonica

Volumn 119, Issue 5, 2002, Pages 273-279

  Obata, Toshio ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Adenosine; ATP sensitive K+ (KATP) channel; Free radical; Microdialysis; Norepinephrine

Indexed keywords

ADENOSINE; ADENOSINE PHOSPHATE; ALPHA 1 ADRENERGIC RECEPTOR; CYCLIC GMP; ECTO 5' NUCLEOTIDASE; HISTAMINE; HYDROXYL RADICAL; NICORANDIL; NITRATE; NITRIC OXIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL AFFECTING AGENT; PROTEIN KINASE C; SINGLET OXYGEN;

CHANNEL GATING; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HEART PROTECTION; HUMAN; IN VIVO STUDY; MEDIATOR RELEASE; MICRODIALYSIS; NONHUMAN; NORADRENALIN RELEASE; NUCLEOTIDE METABOLISM; RECEPTOR BINDING; REPERFUSION INJURY; REVIEW;

5'-NUCLEOTIDASE; ADENOSINE; ANIMALS; HYDROXYL RADICAL; MICRODIALYSIS; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NOREPINEPHRINE; POTASSIUM CHANNELS; RATS;

EID: 0036256479     PISSN: 00155691     EISSN: None     Source Type: Journal    
DOI: 10.1254/fpj.119.273     Document Type: Review

References (37)

1. Myocardial reperfusion injury: Role of oxygen radicals and potential therapy with antioxidants
2. Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium
3. Oxygen radicals can induce preconditioning in rabbit hearts
4. Formation of S-adenosylhomocysteine in the heart. I: An index of free intracellular adenosine
5. Regulation of adenosine formation by the heart
6. Coronary vasoactivity of adenosine in the conscious dog
7. Measurement of neurotransmitter release by intracranial dialysis
8. In vivo monitoring of myocardial interstitial norepinephrine by dialysis technique
9. Cardiac microdialysis in isolated rat hearts: Interstitial purine metabolites during ischemia
10. In vivo monitoring of norepinephrine and ·OH generation on myocardial ischemic injury by dialysis technique
11. 1-adrenoceptors and protein kinase C-mediated activation of ecto-5′-nucleotidase in rat hearts in vivo
12. Alpha 1-adrenoceptor activity regulates release of adenosine from the ischemic myocardium in dogs
13. Beneficial effects of alpha 1-adrenoceptor activity on myocardial stunning in dogs
14. Protein kinase C regulates production of adenosine in hypoxic myocytes of rats
15. Chelerythrine is a potent and specific inhibitor of protein kinase C
16. 1-adrenoceptors in myocardium functional aspects and transmembrane signaling mechanism
17. Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics
18. Histamine increases interstitial adenosine concentration via activation of ecto-5′-nucleotidase in rat hearts in vivo
19. NO and cGMP facilitate adenosine production in rat hearts via activation of ecto-5′-nucleotidase
20. Nitric oxide: Physiology, pathophysiology, and pharmacology
21. Nicorandil increases adenosine 5′-monophosphateprimed interstitial adenosine via activation of ecto5′-nucleotidase in rat hearts
22. Two distinct adenosine-sensitive sites on adenylate cyclase
23. Adenosine inhibits exocytotic release of endogenous noradrenaline in rat heart: A protective mechanism in early myocardial ischemia
24. 1 adenosine receptors in rabbit heart
25. Preconditioning protects ischemic rabbit heart by protein kinase C activation
26. Amphipathic lipid metabolites and arrhythmias during ischemia
27. Ischemic preconditioning increases adenosine release and 5′-nucleotidase activity during myocardial ischemia and reperfusion in dogs. Implications for myocardial salvage
28. Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction
29. Effects of lysophosphatidylcholine on the production of interstitial adenosine via protein kinase C-mediated activation of ecto-5′-nucleotidase in rat hearts
30. Oxygen-derived free radicals in postischemic tissue injury
31. ATP channel by oxygen free radicals produced by xanthine oxidase reaction
32. Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism
33. + channels reduces hydroxyl radicals in the rat myocardium
34. Proarrhythmic effects of pinacidil are partially mediated through enhancement of catecholamine release in isolated perfused guineapig hearts
35. Effects of pinacidil on the sympatho-adrenal system in dogs
36. Prejunctional effects of cromakalim, nicorandil and pinacidil on noradrenergic transmission in rat isolated mesenteric artery
37. An increase of the native interstitial adenosine concentration during histidine application. Naunyn Schmiedebergs