Nicorandil increases adenosine 5′-monophosphate-primed interstitial adenosine via activation of ecto-5′-nucleotidase in rat hearts

Heart and Vessels

Volumn 15, Issue 2, 2000, Pages 81-85

  Sato, T ^a   Obata, T ^a   Yamanaka, Y ^a   Arita, M ^a  

^a OITA UNIVERSITY   (Japan)

Author keywords

Adenosine; Cyclic guanosine monophosphate; Ecto 5 nucleotidase; Microdialysis; Nicorandil

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; ADENOSINE; ADENOSINE DERIVATIVE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; BICARBONATE; CALCIUM CHLORIDE; CHLORAL HYDRATE; CROMAKALIM; CYCLIC GMP; DIMETHYL SULFOXIDE; DISODIUM HYDROGEN PHOSPHATE; DRUG VEHICLE; ECTO 5' NUCLEOTIDASE; GLIBENCLAMIDE; GLUCOSE DERIVATIVE; GUANYLATE CYCLASE; GUANYLATE CYCLASE INHIBITOR; METHYLENE BLUE; NICORANDIL; NITRIC ACID DERIVATIVE; NITRIC OXIDE; NUCLEOSIDE; OXYGEN; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM CHLORIDE; SODIUM CHLORIDE; SODIUM HYDROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIALYSATE; DOSE RESPONSE; DRUG ACTIVITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HEART; INTERSTITIUM; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

5'-NUCLEOTIDASE; ADENOSINE; ADENOSINE MONOPHOSPHATE; ANIMALS; FEMALE; HEART; MALE; MYOCARDIUM; NICORANDIL; RATS; RATS, WISTAR;

EID: 0034522838     PISSN: 09108327     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003800070036     Document Type: Article

References (25)

1. Nicorandil as a hybrid between nitrates and potassium channel activators
2. Clinical profile of nicorandil: An overview of its haemodynamic properties and therapeutic efficacy
3. The cardioprotective effects of nicorandil
4. Antiischemic effects of nicorandil during coronary angioplasty in humans
5. Cardioprotective effect of intravenous nicorandil in patients with successful reperfusion for acute myocardial infarction
6. Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction
7. Protective effects of adenosine in myocardial ischemia
8. Intra- and extracellular formation of adenosine by cardiac tissue
9. It is time to ask what adenosine can do for cardioprotection
10. Cardio-protection with ischemic preconditioning and MLA: Role of adenosine-regulating enzymes?
11. Ecto-5∥-nucleotidase is not required for ischemic preconditioning in rabbit myocardium in situ
12. ATP channels
13. NO and cGMP facilitate adenosine production in rat hearts via activation of ecto-5∥-nucleotidase
14. In vivo monitoring of norepinephrine and OH generation myocardial ischemic injury by dialysis technique
15. 1-adrenoceptors and protein kinase C-mediated activation of ecto-5∥-nucleotidase in rat hearts in vivo
16. The effect of glibenclamide on the production of interstitial adenosine by inhibiting ecto-5∥-nucleotidase in rat hearts
17. Cardiac microdialysis in isolated rat hearts: Interstitial adenosine purine metabolites during ischemia
18. In vivo regulation of rat heart 5∥-nucleotidase by adenine nucleotidase and magnesium
19. 5∥-Nucleotidase in rat heart: Evidence for the occurrence of two soluble enzymes with different substrate specificities
20. Myocardial adenosine formation during hypoxia: Effects of ecto-5∥-nucleotidase inhibition
21. Purification and regulation of an AMP-specific cytosolic 5∥-nucleotidase from dog heart
22. Vascular levels and cGMP-increasing effects of nicorandil administered orally to rats
23. Brain microdialysis
24. Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels
25. Adenosine primes the opening of mitochondrial ATP-sensitive potassium channels: A key step in ischemic preconditioning?