Engraftment and tumorigenesis of HTLV-1 transformed T cell lines in SCID/bg and NOD/SCID mice

Leukemia Research

Volumn 26, Issue 6, 2002, Pages 561-567

  Liu, Yingxian ^a   Dole, Kiran ^a   Stanley, James R L ^b   Richard, Virgile ^b   Rosol, Thomas J ^b   Ratner, Lee ^c   Lairmore, Michael ^b   Feuer, Gerold ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY   (United States)

Author keywords

ATL; HTLV; HTLV proviral clone; Leukemogenesis; SCID mouse; Transformation; Tumorigenesis

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CARCINOGENESIS; CELL IMMORTALIZATION; CELL TRANSFORMATION; CONTROLLED STUDY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS INFECTION; INOCULATION; LEUKEMIA CELL; LEUKEMOGENESIS; LYMPHOCYTE CULTURE; MOLECULAR CLONING; MONONUCLEAR CELL; MOUSE; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SCID MOUSE; T CELL LEUKEMIA; T LYMPHOCYTE;

ANIMALS; CELL LINE, TRANSFORMED; GRAFT SURVIVAL; HTLV-I INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LEUKEMIA-LYMPHOMA, T-CELL, ACUTE, HTLV-I-ASSOCIATED; LEUKOCYTES, MONONUCLEAR; LYMPHOMA; MICE; MICE, INBRED NOD; MICE, SCID; MODELS, ANIMAL; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL;

EID: 0036253407     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(01)00169-2     Document Type: Article

References (8)

1. I reduces viral infectivity in vivo
2. Construction and characterization of infectious human T cell leukemia virus type 1 molecular clones
3. Human T cell leukemia virus type 1 pX-I and pX-II open reading frames are dispensable for the immortalization of primary lymphocytes
4. Establishment of human T cell leukemia virus type I (HTLV-1) T cell lymphomas in SCID mice
5. Potential role of natural killer cells in controlling tumorigenesis by human T cell leukemia viruses
6. HTLV-1 gene expression in adult T cell leukemia cells elicits an NK cell response in vitro and correlates with cell rejection in SCID mice
7. Immune-deficient SCID and NOD/SCID mice models as functional assays for studying normal and malignant human hematopoiesis
8. Humoral hypercalcemia of malignancy: SCID/bg mouse model of adult T cell lymphoma (ATL) independent of HTLV-1 tax expression