Identification of phenyl-pyridine-2-carboxylic acid derivatives as novel cell cycle inhibitors with increased selectivity for cancer cells

Anti-Cancer Drugs

Volumn 13, Issue 4, 2002, Pages 359-366

  Berthel, Steven J ^a   Marks, Ian M ^a   Yin, Xuefeng ^a   Mischke, Steven G ^a   Orzechowski, Lucja ^a   Pezzoni, Gabriella ^a   Sala, Franca ^a   Vassilev, Lyubomir T ^a  

^a HOFFMANN LA ROCHE INC   (United States)

Author keywords

Antitumor; Cancer cells; Cell cycle; Mitosis; Xenografts

Indexed keywords

ANTIMITOTIC AGENT; CYTOTOXIC AGENT; PICOLINIC ACID DERIVATIVE; RO 414439; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG TOLERABILITY; FEMALE; HUMAN; HUMAN CELL; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARBOXYLIC ACIDS; CELL CYCLE; CELL SURVIVAL; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, NUDE; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0036242235     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200204000-00004     Document Type: Article

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