The birth and death of photoreceptors: The Friedenwald Lecture

Investigative Ophthalmology and Visual Science

Volumn 43, Issue 5, 2002, Pages 1300-1309

  Papermaster, David S ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MEMBRANE PROTEIN; RAB PROTEIN; RAB8 PROTEIN; RHODOPSIN; UNCLASSIFIED DRUG;

APOPTOSIS; BLINDNESS; CELL POLARITY; CONFERENCE PAPER; FROG; HUMAN; INTRACELLULAR TRANSPORT; MOLECULAR MECHANICS; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; RETINA DEGENERATION; RETINA ROD; RETINA ROD OUTER SEGMENT; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; AWARDS AND PRIZES; BIOLOGICAL TRANSPORT; CELL DEATH; CELL SURVIVAL; FLORIDA; GTP-BINDING PROTEINS; HUMANS; OPHTHALMOLOGY; RETINAL DEGENERATION; RHODOPSIN; RODS (RETINA); SOCIETIES, SCIENTIFIC;

EID: 0036241296     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (96)

1. Structure of visual pigments 1: Purification, molecular weight and composition of bovine visual pigment 500
2. Molecular basis of visual excitation
3. Rhodopsin content in the outer segment membranes of bovine and frog retinal rods
4. Visual cells and the concept of renewal
5. Membrane biosynthesis in the frog retina: Opsin transport in the photoreceptor cell
6. Rhodopsin carbohydrate: Structure of small oligosaccharides attached at two sites near the NH2 terminus
7. Messenger RNA of opsin from bovine retina: Isolation and partial sequence of the in vitro translation product
8. In vitro biosynthesis, core-glycosylation and membrane integration of opsin
9. Bovine opsin has more than one signal sequence
10. Some observations on the ultrastructure and morphogenesis of photoreceptors
11. Disk morphogenesis in vertebrate photoreceptors
12. Actin in the photoreceptor connecting cilium: Immunocytochemical localization to the site of outer segment disk formation
13. Myosin VIIa, the product of the Usher 1B syndrome gene, is concentrated in the connecting cilia of photoreceptor cells
14. Cytochalasin D disrupts outer segment disc morphogenesis in situ in rabbit retina
15. A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration
16. Biosynthetic and immunochemical characterization of large protein in frog and cattle rod outer segment membranes
17. Light-induced binding of guanosinetriphosphatase to bovine photoreceptor membranes: Effect of limited proteolysis of the membranes
18. Characterization and analysis of frog photoreceptor membranes
19. Protein complement of rod outer segments of frog retina
20. Localization of peripherin/rds in the disk membranes of cone and rod photoreceptors: Relationship to disk membrane morphogenesis and retinal degeneration
21. Molecular cloning, primary structure, and orientation of the vertebrate photoreceptor cell protein peripherin in the rod outer segment disk membrane
22. Cloning of the cDNA for a novel photoreceptor membrane protein (rom-1) identifies a disk rim protein family implicated in human retinopathies
23. Photoreceptor membrane proteins, phototransduction, and retinal degenerative diseases. The Friedenwald Lecture
24. Rhodopsin structure, function, and topography. The Friedenwald Lecture
25. Differences in the protein composition of bovine retinal rod outer segment disk and plasma membranes isolated by a ricin-gold-dextran density perturbation method
26. Some contributions to the cell biology of photoreceptors. The Proctor Lecture
27. Changes in structure of the disks of retinal rods in hypotonic solutions
28. Surfaces of rod photoreceptor disk membranes: Integral membrane components
29. Immunocytochemical localization of opsin in outer segments and Golgi zones of frog photoreceptor cells. An electron microscope analysis of cross-linked albumin-embedded retinas
30. Immunocytochemical localization of a large intrinsic membrane protein to the incisures and margins of frog rod outer segment disks
31. Molecular cloning, membrane topology, and localization of bovine rom-1 in rod and cone photoreceptor cells
32. Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration
33. The 220-kDa rim protein of retinal rod outer segments is a member of the ABC transporter superfamily
34. Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knock-out mice
35. Stargardt's ABCR is localized to the disc membrane of retinal rod outer segments
36. ABCR, the ATP-binding cassette transporter responsible for Stargardt macular dystrophy, is an efficient target of all-trans-retinal-mediated photooxidative damage in vitro: Implications for retinal disease
37. Rhodopsin rotates in the visual receptor membrane
38. Lateral diffusion of rhodopsin in the photoreceptor membrane
39. Membrane biogenesis: An overview
40. Membrane assembly in retinal photoreceptors I. Freeze-fracture analysis of cytoplasmic vesicles in relationship to disc assembly
41. Immunocytochemistry of retinal membrane protein biosynthesis at the electron microscopic level by the albumin embedding technique
42. Immunoferritin localization of intracellular antigens: The use of ultracryotomy to obtain ultrathin sections suitable for direct immunoferritin staining
43. Solid phase conjugation of ferritin to Fab fragments for use in antigen localization on thin sections
44. Cone lamellae and red and green rod outer segment disks contain a large intrinsic membrane protein on their margins: An ultrastructural immunocytochemical study of frog retinas
45. Ultrastructural localization of retinal photoreceptor proteins
46. Rapid embedding of tissues in Lowicryl K4M for immunoelectron microscopy
47. Fine structure of a periciliary ridge complex of frog retinal rod cells revealed by ultrahigh resolution scanning electron microscopy
48. Vesicular transport of newly synthesized opsin from the Golgi apparatus toward the rod outer segment: Ultrastructural immunocytochemical and autoradiographic evidence in Xenopus retinas
49. Biosynthesis and vectorial transport of opsin on vesicles in retinal rod photoreceptors
50. Freeze-fracture studies of photoreceptor membranes: New observations bearing upon the distribution of cholesterol
51. Immunocytochemical localization of opsin in the cell membrane of developing rat retinal photoreceptors
52. Opsin accumulation in photoreceptor inner segment plasma membranes of dystrophic RCS rats
53. Opsin distribution and synthesis in degenerating photoreceptors of rd mutant mice
54. Rod photoreceptor neurite sprouting in retinitis pigmentosa
55. Immunoaffinity partitioning of retinal subcellular fractions using the streptavidin-biotin-bridge
56. Immunoaffinity partitioning of photoreceptor membranes by the streptavidin-biotin-bridge in an aqueous polymer two-phase system
57. The streptavidin-biotin-bridge technique: Application in light and electron microscope immunocytochemistry
58. Receptor-mediated endocytosis of asialoglycoproteins by rat hepatocytes: Receptor-positive and receptor-negative endosomes
59. Polarized sorting of rhodopsin on post-Golgi membranes in frog retinal photoreceptor cells
60. Alpha Aand alpha B-crystallin in the retina: Association with the post-Golgi compartment of frog retinal photoreceptors
61. Rab6 is associated with a compartment that transports rhodopsin from the trans-Golgi to the site of rod outer segment disk formation in frog photoreceptors
62. rab8 in retinal photoreceptors may participate in rhodopsin transport and in rod outer segment disk morphogenesis
63. Rab proteins and post-Golgi trafficking of rhodopsin in photoreceptor cells
64. Cytoplasmic domain of rhodopsin is essential for post-Golgi vesicle formation in a retinal cell-free system
65. Regulation of sorting and post-Golgi trafficking of rhodopsin by its C-terminal sequence QVS(A)PA
66. Post-Golgi trafficking of rhodopsin in retinal photoreceptors
67. Involvement of the Golgi apparatus in sorting of materials to opposite ends of frog rod retinal photoreceptors
68. Rhodopsin's carboxy-terminal cytoplasmic tail acts as a membrane receptor for cytoplasmic dynein by binding to the dynein light chain Tctex-1
69. Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation
70. Characterization of the Xenopus rhodopsin gene
71. Transgene expression in Xenopus rods
72. The photoreceptors and pigment epithelium of the larval Xenopus retina: Morphogenesis and outer segment renewal
73. Differential growth of the neural retina in Xenopus laevis larvae
74. Immunocytochemical reactivity of Xenopus laevis retinal rods and cones with several monoclonal antibodies to visual pigments
75. Ocular findings in patients with autosomal dominant retinitis pigmentosa and rhodopsin, proline-347-leucine
76. A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment
77. Transgenic mice carrying the dominant rhodopsin mutation P347S: Evidence for defective vectorial transport of rhodopsin to the outer segments
78. A functional rhodopsin-green fluorescent protein fusion protein localizes correctly in transgenic Xenopus laevis retinal rods and is expressed in a time-dependent pattern
79. Identification of an outer segment targeting signal in the COOH terminus of rhodopsin using transgenic Xenopus laevis
80. 3H]palmitic acid
81. Three-dimensional structure of the cytoplasmic face of the G protein receptor rhodopsin
82. Crystal structure of rhodopsin: A G protein-coupled receptor
83. Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of g-protein-coupled receptors (gpcrs)
84. Cytoplasmic dynein regulation by subunit heterogeneity and its role in apical transport
85. Rab8 promotes polarized membrane transport through reorganization of actin and microtubules in fibroblasts
86. A rab8 mutant causes accumulation of rhodopsin-bearing membranes and cell death in transgenic Xenopus rods
87. Evidence from normal and degenerating photoreceptors that two outer segment integral membrane proteins have separate transport pathways
88. Death at an early age; apoptosis in inherited retinal degenerations
89. Widespread elimination of naturally occurring neuronal death in Bax-deficient mice
90. Synergistic effect of Bcl-2 and BAG-1 on the prevention of photoreceptor cell death
91. Expression of Bcl-2 protects against photoreceptor degeneration in retinal degeneration slow (rds) mice
92. Overexpression of Bcl-2 or Bcl-XL transgenes and photoreceptor degeneration
93. Necessary but insufficient
94. Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants