Neither LAT nor open reading frame P mutations increase expression of spliced or intron-containing ICP0 transcripts in mouse ganglia latently infected with herpes simplex virus

Journal of Virology

Volumn 76, Issue 10, 2002, Pages 4764-4772

  Chen, Shun Hua ^a   Lee, Lily Yeh ^a   Garber, David A ^a   Schaffer, Priscilla A ^a   Knipe, David M ^a   Coen, Donald M ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN ICP0; THYMIDINE KINASE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DELETION MUTANT; GANGLION; GENE EXPRESSION; HERPES; HERPES SIMPLEX VIRUS; INTRON; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING; TRANSCRIPTION REGULATION; VIRUS LATENCY; VIRUS MUTATION;

ANIMALS; DISEASE MODELS, ANIMAL; DNA, VIRAL; GENE EXPRESSION REGULATION, VIRAL; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; IMMEDIATE-EARLY PROTEINS; INTRONS; MALE; MICE; MUTATION; OPEN READING FRAMES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYMIDINE KINASE; TRIGEMINAL GANGLION; UBIQUITIN-PROTEIN LIGASES; VIRAL PROTEINS; VIRUS ACTIVATION; VIRUS LATENCY;

EID: 0036239509     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.10.4764-4772.2002     Document Type: Article

References (51)

1. Herpes simplex virus type 1 immediate-early protein ICP0 and its isolated ring finger domain act as ubiquitin E3 ligases in vitro
2. Open reading frame P - A herpes simplex virus gene repressed during productive infection encodes a protein that binds a splicing factor and reduces synthesis of viral proteins made from spliced mRNA
3. The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency
4. Herpes simplex virus type 1 ICP0 plays a critical role in the de novo synthesis of infectious virus following transfection of viral DNA
5. Herpes simplex virus type 1 ICP0 regulates expression of immediate-early, early, and late genes in productively infected cells
6. Alternatively spliced mRNAs predicted to yield frame-shift proteins and stable intron 1 RNAs of the herpes simplex virus I regulatory gene α0 accumulation in the cytoplasm of infected cells
7. Herpes simplex viruses with mutations in the gene encoding ICP0 are defective in gene expression
8. Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation
9. A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus
10. Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus
11. Regulation of neighboring gene expression by the herpes simplex virus type 1 thymidine kinase gene
12. Identification of the latency-associated transcript promoter by expression of rabbit beta-globin mRNA in mouse sensory nerve ganglia latently infected with a recombinant herpes simplex virus
13. Construction and characterization of herpes simplex virus type I mutants with defined lesions in immediate-early gene 1
14. ICP0 induces the accumulation of colocalizing conjugated ubiquitin
15. Herpes simplex virus latency-associated transcript is a stable intron
16. Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice
17. A LAT-associated function reduces productive-cycle gene expression during acute infection of murine sensory neurons with herpes simplex virus type 1
18. ICP0 is required for efficient reactivation of herpes simplex virus type 1 from neuronal latency
19. Accumulation of viral transcripts and DNA during establishment of latency by herpes simplex virus
20. Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus
21. Antisense RNA: Function and fate of duplex RNA in cells of higher eukaryotes
22. Expression of a herpes simplex virus 1 open reading frame antisense to the gamma 1 34.5 gene and transcribed by an RNA 3′ coterminal with the unspliced latency-associated transcript
23. The regulation of synthesis and properties of protein product of open reading frame P of the herpes simplex virus 1 genome
24. 134.5 transcripts and latency-associated transcripts
25. A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency
26. Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency
27. Detection of herpes simplex virus type 1 gene expression in latently and productively infected mouse ganglia using the polymerase chain reaction
28. Herpes simplex virus type 1 latency-associated transcripts suppress viral replication and reduce immediate-early gene mRNA levels in a neuronal cell line
29. The complete DNA sequence of the long unique region in the genome of herpes simplex virus type 1
30. Detection of herpes simplex virus type 1-encoded RNA by polymerase chain reaction: Different pattern of viral RNA detection in latently infected murine trigeminal ganglia following in vitro or in vivo reactivation
31. Mapping of low abundance latency-associated RNA in the trigeminal ganglia of mice latently infected with herpes simplex virus type 1
32. Characterization of the IE110 gene of herpes simplex virus type 1
33. Repression of viral transcription during herpes simplex virus latency
34. Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice
35. 1134.5 gene and may account for the attenuation of the mutant virus
36. Herpes simplex viruses and their replication
37. Deletion mutants in the gene encoding the herpes simplex virus type 1 immediate-early protein ICP0 exhibit impaired growth in cell culture
38. Comprehensive quantification of herpes simplex virus latency at the single-cell level
39. Human herpesviruses: A consideration of the latent state
40. RNA complementary to a herpesvirus alpha gene mRNA is prominent in latently infected neurons
41. Isolation and characterization of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate-early polypeptide Vmw110
42. Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures
43. Analysis by RNA-PCR of latency and reactivation of herpes simplex virus in multiple neuronal tissues
44. The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity
45. Antiviral properties of a dominant negative mutant of the herpes simplex virus type-1 regulatory protein ICP0
46. Identification of dominant-negative mutants of the herpes simplex virus type 1 immediate-early protein ICP0
47. Atypical splicing of the latency-associated transcripts of herpes simplex type 1
48. A novel class of transcripts expressed with late kinetics in the absence of ICP4 spans the junction between the long and short segments of the herpes simplex virus type 1 genome
49. The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine
50. Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: Evidence for neuron specificity and for a large LAT transcript