Transcription of the derepressed open reading frame p of herpes simplex virus 1 precludes the expression of the antisense γ134.5 Gene and may account for the attenuation of the mutant virus

Journal of Virology

Volumn 71, Issue 10, 1997, Pages 7750-7757

  Randall, Glenn ^a   Roizman, Bernard ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ARTICLE; GENE EXPRESSION; GENOTYPE; HERPES SIMPLEX VIRUS 1; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN ANALYSIS; VIRAL GENETICS; VIRUS ATTENUATION; VIRUS EXPRESSION; VIRUS MUTANT; VIRUS TRANSCRIPTION;

EID: 0030823640     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.10.7750-7757.1997     Document Type: Article

References (32)

1. Ackermann, M., D. K. Braun, L. Pereira, and B. Roizman. 1984. Characterization of a proteins 0, 4, and 27 with monoclonal antibodies. J. Virol. 52:108-118.
2. Ackermann, M., J. Chou, M. Sarmiento, R. A. Lerner, and B. Roizman. 1986. Identification by antibody to a synthetic peptide of a protein specified by a diploid gene located in the terminal repeats of the L component of the herpes simplex virus genome, J. Virol. 58:843-850.
3. - deletion mutant. J. Virol. 56:207-215.
4. Andreansky, S. S., B. He, G. J. Gillespie, L. Soroceanu, J. Markert, J. Chou, B. Roizman, and R. J. Whitley. 1996. The application of genetically engineered herpes simplex viruses to the treatment of experimental brain tumors. Proc. Natl. Acad. Sci. USA 93:11313-11318.
5. L region. J. Virol. 67:632-642.
6. Bruni, R., and B. Roizman. 1996. Open reading frame P - a herpes simplex virus gene repressed during productive infection encodes a protein that binds a splicing factor and reduces synthesis of viral proteins made from spliced mRNA. Proc. Natl. Acad. Sci. USA 93:10423-10427.
7. L43 gene of herpes simplex virus 1: potential implications for regulation of gene expression by antisense transcription. J. Virol. 70:7663-7668.
8. - mutants of herpes simplex virus I. Proc. Natl. Acad. Sci. USA 92:10516-10520.
9. 134.5, a gene nonessential for growth in culture. Science 250:1262-1266.
10. 134.5 gene of herpes simplex virus, J. Virol. 68:8304-8311.
11. 134.5, which maps in inverted repeats, is conserved in several limited-passage isolates but not in strain 17syn +. J. Virol. 64:1014-1020.
12. 134.5 gene of herpes simplex virus I precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programmed cell death in neuronal cells. Proc. Natl. Acad. Sci. USA 89:3266-3270.
13. 134.5 gene function which blocks the host response to infection maps in the homologous domain of the genes expressed during growth arrest and DNA damage. Proc. Natl. Acad. Sci. USA 91:5247-5251.
14. Ejercito, P. M., E. D. Kieff, and B. Roizman. 1967. Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells. J. Gen. Virol. 2:357-364.
15. Faber, S. W., and K. W. Wilcox. 1986. Association of the herpes simplex virus regulatory protein ICP4 with specific nucleotide sequences in DNA. Nucleic Acids Res. 14:6067-6083.
16. 134.5 gene of herpes simplex virus to preclude the premature shutotf of total protein synthesis in infected human cells. J. Virol. 70:84-90.
17. 134.5 protein of herpes simplex virus I complexes with protein phosphatase la to dephosphorylate the α subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. Proc. Natl. Acad. Sci. USA 94:843-848.
18. Igarishi, K., R. Fawl, R. J. Roller, and B. Roizman. 1993. Construction and properties of a recombinant herpes simplex virus 1 lacking both S-component origins of DNA synthesis. J. Virol. 67:2123-2132.
19. Lagunoff, M., G. Randall, and B. Roizman. 1996. Phenotypic properties of herpes simplex virus 1 containing a derepressed open reading frame P gene. J. Virol. 70:1810-1817.
20. 134.5 gene and transcribed by an RNA 3′ coterminal with the unspliced latency-associated transcript. J. Virol. 68: 6021-6028.
21. Lagunoff, M., and B. Roizman. 1995. The regulation of synthesis and properties of the protein product of open reading frame P of the herpes simplex virus 1 genome. J. Virol. 69:3615-3623.
22. Leopardi, R., N. Michael, and B. Roizman. 1995. Repression of the herpes simplex virus 1 α4 gene by its gene product (ICP4) within the context of the viral genome is conditioned by the distance and stereoaxial alignment of the ICP4 DNA binding site relative to the TATA box. J. Virol. 69:3042-3048.
23. - mutant of herpes simplex virus 1. J. Virol. 71:5560-5569.
24. Michael, N., and B. Roizman. 1993. Repression of the herpes simplex virus α4 gene by its gene product occurs within the context of the viral genome and is associated with all three identified cognate sites. Proc. Natl. Acad. Sci. USA 90:2286-2290.
25. Post, L. E., S, Mackem, and B. Roizman. 1981. Regulation of a genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with a gene promoters. Cell 24:555-565.
26. Post, L. E., and B. Roizman. 1981. A generalized technique for deletion of specific genes in large genomes: α gene 22 of herpes simplex virus 1 is not essential for growth. Cell 25:227-232.
27. Reed, L. J., and H. Muench. 1938. A simple method of estimating fifty percent endpoints. Am. J. Hyg. 27:493-497.
28. Spivack, J. G., and N. W. Fraser. 1987. Detection of herpes simplex virus type 1 transcripts during latent infection in mice. J. Virol. 61:3841-3847.
29. Stevens, J. G., E. K. Wagner, G. B. Devi-Rao, M. L. Cook, and L. T. Feldman. 1987. RNA complementary to a herpesvirus a gene mRNA is prominent in latently infected neurons. Science 235:1056-1059.
30. 134.5 deletion mutants in rodent models. J. Clin. Invest. 91:2837-2843.
31. Yen, L., and P. A. Schaffer. 1993. A novel class of transcripts expressed with late kinetics in the absence of ICP4 spans the junction between the long and short segments of the herpes simplex virus type 1 genome. J. Virol. 67:7373-7382.
32. Zwaagstra, J. C., H. Ghiasi, S. M. Slanina, A. B. Nesburn, S. C. Wheatley, K. Lillycrop, J. Wood, D. S. Latch Man, K. Patel, and S. L. Wechsler. 1990. Activity of herpes simplex virus type I latency-associated transcript (LAT) in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript. J. Virol. 64:5019-5028.