Neural Wiskott-Aldrich syndrome protein (N-WASP) is the specific ligand for Shigella VirG among the WASP family and determines the host cell type allowing actin-based spreading

Cellular Microbiology

Volumn 4, Issue 4, 2002, Pages 223-233

  Suzuki, Toshihiko ^a,b   Mimuro, Hitomi ^b   Suetsugu, Shiro ^b   Miki, Hiroaki ^a,b   Takenawa, Tadaomi ^a,b   Sasakawa, Chihiro ^b  

^a JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BACTERIAL PROTEIN; CALMODULIN BINDING PROTEIN; LIGAND; PLECKSTRIN; PROTEIN VIRG; UNCLASSIFIED DRUG; WISKOTT ALDRICH SYNDROME PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BACTERIAL VIRULENCE; CARBOXY TERMINAL SEQUENCE; CELL SPREADING; CELL TYPE; CHIMERA; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HEMATOPOIETIC CELL; HOST CELL; LISTERIA; MACROPHAGE; MOLECULAR INTERACTION; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SHIGELLA; SHIGELLOSIS; THROMBOCYTE;

ACTINS; BACTERIAL PROTEINS; BIOLOGICAL TRANSPORT; CELLS, CULTURED; DNA-BINDING PROTEINS; HUMANS; LIGANDS; MACROPHAGES; NERVE TISSUE PROTEINS; SHIGELLA; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; WISKOTT-ALDRICH SYNDROME PROTEIN, NEURONAL;

ANIMALIA; BACTERIA (MICROORGANISMS); LISTERIA; SHIGELLA;

EID: 0036232011     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1462-5822.2002.00185.x     Document Type: Article

References (39)

1. SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development
2. Identification of icsA, a plasmid locus of Shigella flexneri that governs bacterial intra- and intercellular spread through interaction with F-actin
3. Isolation of a novel gene mutated in Wiskott-Aldrich syndrome
4. Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin- based motility
5. Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling
6. Unipolar localization and ATPase activity of IcsA, a Shigella flexneri protein involved in intracellular movement
7. The interleukin 1beta-converting enzyme, caspase 1, is activated during Shigella flexneri-induced apoptosis in human monocyte-derived macrophages
8. Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals
9. Shigella invasion of macrophage requires the insertion of IpaC into the host plasma membrane: Functional analysis of IpaC
10. In vitro reconstitution of cortical actin assembly sites in budding yeast
11. virG, a plasmid-coded virulence gene of Shigella flexneri: Identification of the virG protein and determination of the complete coding sequence
12. Bee1, a yeast protein with homology to Wiskott-Aldrich syndrome protein, is critical for the assembly of cortical actin cytoskeleton
13. Actin pedestal formation by enteropathogenic Escherichia coli and intracellular motility of Shigella flexneri are abolished in N-WASP- defective cells
14. A genetic determinant required for continuous reinfection of adjacent cells on a large plasmid in Shigella flexneri 2a
15. N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases
16. WAVE, a novel-WASP family protein involved in actin reorganization induced by Rac
17. Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP
18. A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization
19. How WASP-family proteins and the Arp2/3 complex convert intracellular signals into cytoskeletal structures
20. Pathogen-induced apoptosis of macrophages: A common end for different pathogenic strategies
21. Expression of Wiskott-Aldrich syndrome protein (WASP) gene during hematopoietic differentiation
22. The pathogenesis of Shigella flexneri infection: Lessons from in vitro and in vivo studies
23. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex
24. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
25. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate
26. Wiskott-Aldrich syndrome protein is associated with the adapter protein Grb2 and the epidermal growth factor receptor in living cells
27. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility
28. Studies of the expression of the Wiskott-Aldrich syndrome protein
29. Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex
30. Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP), that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP
31. Molecular basis of the intracellular spreading of Shigella
32. Extracellular transport of VirG protein in Shigella
33. Functional analysis of Shigella VirG domains essential for interaction with vinculin and actin-based motility
34. Neural Wiskott-Aldrich syndrome protein is implicated in actin-based motility of Shigella flexneri
35. Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells
36. WASP and WAVE family proteins: Key molecules for rapid rearrangement of cortical actin filaments and cell movement
37. The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization
38. The world according to Arp: Regulation of actin nucleation by the Arp2/3 complex
39. Interaction of human Arp2/3 and the Listeria monocytogenes ActA protein in actin filament nucleation