Transcription of multiple var genes by individual, trophozoite-stage Plasmodium falciparum cells expressing a chondroitin sulphate A binding phenotype

Molecular Microbiology

Volumn 43, Issue 5, 2002, Pages 1285-1293

  Duffy, Michael F ^a,c   Brown, Graham V ^b,c   Basuki, Wanny ^a   Krejany, Efrosinia O ^a   Noviyanti, Rintis ^b   Cowman, Alan F ^b   Reeder, John C ^b,d  

^a EIJKMAN INSTITUTE FOR MOLECULAR BIOLOGY   (Indonesia)

^b WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d PAPUA NEW GUINEA INSTITUTE OF MEDICAL RESEARCH   (Papua New Guinea)

Author keywords

[No Author keywords available]

Indexed keywords

CHONDROITIN 4 SULFATE; ERYTHROCYTE MEMBRANE PROTEIN 1; PROTEIN; RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL ADHESION; CELL ASSAY; CONTROLLED STUDY; ERYTHROCYTE; GENE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC CODE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; NONHUMAN; PARASITE; PARASITOSIS; PHENOTYPE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN VARIANT; TROPHOZOITE; VAR GENE;

ANIMALS; CELL ADHESION; CHONDROITIN SULFATES; ERYTHROCYTES; HUMANS; MALARIA, FALCIPARUM; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; TRANSCRIPTION, GENETIC;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0036227659     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.02822.x     Document Type: Article

References (32)

1. Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes
2. Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria
3. Plasmodium falciparum domain mediating adhesion to chondroitin sulfate A: A receptor for human placental infection
4. Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria
5. Multiple ligands for cytoadherence can be present simultaneously on the surface of Plasmodium falciparum-infected erythrocytes
6. Developmental selection of var gene expression in Plasmodium falciparum
7. Identification of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) as the rosetting ligand of the malaria parasite P. falciparum
8. Adhesion of malaria-infected red blood cells to chondroitin sulfate A under flow conditions
9. Intracluster recombination and var transcription switches in the antigenic variation of Plasmodium falciparum
10. Cooperative silencing elements in var genes
11. Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum
12. Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta
13. Maternal antibodies block malaria
14. Variant antigens and endothelial receptor adhesion in Plasmodium falciparum
15. A simple RNA analysis method shows var and rif multigene family expression patterns in Plasmodium falciparum
16. Multiple var gene transcripts are expressed in Plasmodium falciparum infected erythrocytes selected for adhesion
17. Biological and biochemical characteristics of cytoadhesion of Plasmodium falciparum-infected erythrocytes to chondroitin-4-sulfate
18. A simple method for typing Plasmodium falciparum merozoite surface antigens 1 and 2 (MSA 1 and MSA2) using a dimorphic-form specific polymerase chain reaction
19. Diversity of agglutinating phenotype, cytoadherence, and rosette-forming characteristics of Plasmodium falciparum isolates from Papua New Guinean children
20. The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by PfEMP1
21. Polymorphism of the TRAP gene of Plasmodium falciparum
22. Antigenic variation in malaria: In situ switching, relaxed and mutually exclusive transcription of var genes during intra-erythrocytic development in Plasmodium falciparum
23. Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes
24. Analysis of adhesive domains from the A4VAR Plasmodium falciparum erythrocyte membrane protein-1 identifies a CD36 binding domain
25. Identification of a Plasmodium falciparum intercellular adhesion molecule-1 binding domain: A parasite adhesion trait implicated in cerebral malaria
26. The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes
27. A study of var gene transcription in vitro using universal var gene primers
28. Human malaria parasites in continuous culture
29. Amplification of the multidrug resistance gene pfmdr1 in Plasmodium falciparum has arisen as multiple independent events
30. An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration
31. Genomic distribution and functional characterisation of two distinct and conserved Plasmodium falciparum var gene 5′ flanking sequences
32. Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins