TP53 mutations in human meningiomas

International Journal of Biological Markers

Volumn 17, Issue 1, 2002, Pages 42-48

  Verheijen, F M ^a   Sprong, M ^a   Kloosterman, J M E ^a   Blaauw, G ^a   Thijssen, J H H ^a   Blankenstein, M A ^a  

^a TWENTEBORG HOSPITAL   (Netherlands)

Author keywords

Meningioma; P53; PCR SSCP; TP53

Indexed keywords

DNA; NUCLEOTIDE; PROTEIN P53;

ADULT; AGED; ALLELE; ARTICLE; BENIGN TUMOR; CANCER RECURRENCE; CENTRAL NERVOUS SYSTEM TUMOR; CLINICAL ARTICLE; CODON; CONTROLLED STUDY; DISEASE COURSE; DNA DETERMINATION; DNA POLYMORPHISM; DNA SEQUENCE; EXON; FEMALE; GENE; GENE MUTATION; GENE OVEREXPRESSION; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INCIDENCE; INTRACRANIAL TUMOR; INTRON; MALE; MENINGIOMA; POLYMERASE CHAIN REACTION; PROTEIN DOMAIN; QUANTITATIVE ANALYSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; TP53 GENE; TUMOR SUPPRESSOR GENE;

EID: 0036220460     PISSN: 03936155     EISSN: None     Source Type: Journal    
DOI: 10.5301/JBM.2008.3174     Document Type: Article

References (47)

1. Tumor suppressor genes: Possible functions in the negative regulation of cell proliferation
2. How p53 suppresses cell growth
3. P53 mutations in human cancers
4. Tumourigenesis associated with the p53 tumour suppressor gene
5. p53 and the CNS: Tumors and developmental abnormalities
6. Presidential address: The histopathology of meningiomas. A reflection of origins and expected behavior?
7. Immunohistochemical detection of p53 protein in tumours of the central nervous system
8. Immunohistochemical evaluation of erbB-2 and p53 protein expression in benign and atypical human meningiomas
9. Expression of p53, MDM2 protein and KI-67 antigen in recurrent meningiomas
10. Prognostic significance of p53 and p21WAF1/CIP1 immunoreactivity and tumor micronecrosis for recurrence of meningiomas
11. Role of p53 gene mutation in tumor aggressiveness of intracranial meningiomas
12. The p53 tumor suppressor gene and gene product
13. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life
14. Constitutional p53 mutations associated with brain tumors in young adults
15. Detection of TP53 gene mutation in human meningiomas: A study using immunohistochemistry, polymerase chain reaction/single-strand conformation polymorphism and DNA sequencing techniques on paraffin-embedded samples
16. Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system
17. Sequencing analysis of RNA and DNA of exons 1 through 11 shows p53 gene alterations to be present in almost 100% of head and neck squamous cell cancers
18. DNA sequencing with chain-terminating inhibitors
19. Mechanisms of p53-mediated apoptosis
20. p53, the cellular gatekeeper for growth and division
21. Accumulation of wild-type p53 in meningiomas
22. Correlation between MIB-1 staining index and the immunoreactivity of p53 protein in recurrent and non-recurrent meningiomas
23. P53 overexpression and proliferative potential in malignant meningiomas
24. Correlation between histological grade, MIB-1, p53, and recurrence in 69 completely resected primary intracranial meningiomas with a 6 year mean follow-up
25. Novel nonsense mutation of the KAL gene in two brothers with Kallmann syndrome
26. Detection of p53 gene mutations in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products
27. Codon 72 polymorphism of the TP53 gene
28. Characterization of a frequent polymorphism in the coding sequence of the TP53 gene in colonic cancer patients and a control population
29. Accll polymorphism of the p53 gene
30. p53 codon 72 polymorphism in vulval cancer and vulval intraepithelial neoplasia
31. Germ line polymorphism of p53 and CYP1A1 genes involved in human lung cancer
32. Prognostic value of mutations and a germ line polymorphism of the p53 gene in non-small cell lung carcinoma: Association with clinicopathological features
33. Analysis of a germ line polymorphism of the p53 gene in lung cancer patients; discrete results with smoking history
34. P53 codon 72Arg polymorphism is not a risk factor for carcinogenesis in the Chinese
35. Homozygous arginine at codon 72 of p53 has no prognostic significance in cervical cancer
36. Risk of cervical cancer is not increased in Chinese carrying homozygous arginine at codon 72 of p53
37. p53 codon 72 polymorphism and risk of cervical cancer in UK
38. Correlation of the mutation of p53 gene and the polymorphism at codon 72 in smoking-related non-small cell lung cancer patients
39. Polymorphism at codon 36 of the p53 gene
40. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
41. Tumor suppressor p53: Regulation and function
42. Identification of a polymorphism in intron 2 of the p53 gene
43. Biologic heterogeneity of angiomatous meningiomas
44. PCR-SSCP analysis of p53 gene in human primary brain tumor
45. Homozygous deletions of the CDKN2/p16 gene in dural hemangiopericytomas
46. Malignant meningioma in Gorlin's syndrome: Cytogenetic and p53 gene analysis. Case report