Positive effect of transplantation of hNT Neurons (NTera 2/D1 cell-line) in a model of familial amyotrophic lateral sclerosis

Experimental Neurology

Volumn 174, Issue 2, 2002, Pages 169-180

  Garbuzova Davis, Svitlana ^a   Willing, Alison E ^a   Milliken, Melissa ^a   Saporta, Samuel ^a   Zigova, Tanya ^a   Cahill, David W ^a   Sanberg, Paul R ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Behavior; Cu Zn superoxide dismutase; Familial amyotrophic lateral sclerosis; hNT Neurons; Transgenic mice; Transplantation

Indexed keywords

ALANINE; GLYCINE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL FUNCTION; CELL SURVIVAL; CELL TRANSPLANTATION; CONTROLLED STUDY; COORDINATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LIFESPAN; LOCOMOTION; MALE; MOTONEURON; MOTOR DYSFUNCTION; MOUSE; MUSCLE STRENGTH; NONHUMAN; PARALYSIS; PRIORITY JOURNAL; SPINAL CORD VENTRAL HORN;

EID: 0036218669     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2002.7860     Document Type: Article

References (40)

1. Retinoic acid induces neuronal differentiation of cloned human embryonal carcinoma cell line in vitro
2. Intrastriatal and intranigral grafting of hNT neurons in the 6-OHDA rat model of Parkinson's disease
3. Hyperactivity and hypoactivity in a rat model of Huntington's disease: The systemic 3-nitropropionic acid model
4. Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats
5. Overview of motor neuron disease: Classification and nomenclature
6. Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis
7. Preclinical testing of neuroprotective neurotrophic factors in a model of chronic motor neuron degeneration
8. Animal models of Amyotrophic lateral sclerosis
9. Treatment of amyotrophic lateral sclerosis
10. Cu/Zn superoxide dismutase activity at different ages in sporadic amyotrophic lateral sclerosis
11. Transplantation of human cultured neurons (HNT) protects against 6-hydroxydopamine-induced parkinsonism in adult rats
12. Human NT2 neurons express a large variety of neurotransmission phenotypes in vitro
13. Transgenic animal models of familial amyotrophic lateral sclerosis
14. Motor neuron degeneration in mice that express a human Cu/Zn superoxide dismutase mutation
15. Functional synapses are formed between human NTera2 (NT2N, hNT) neurons grown on astrocytes
16. Differential effects of spinal cord gray and white matter on process outgrowth from grafted human NTERA2 neurons (NT2N, hNT)
17. ALS therapy: Targets for the future
18. Neural transplantation of hNT neurons for Huntington's disease
19. Expression of tyrosine hydroxylase in newly differentiated neurons from a human cell line (hNT)
20. Neuromuscular function impairment is not caused by motor neurone loss in FALS mice: An electromyographic study
21. Transplanted human neurons derived from a teratocarcinoma cell line (NTera-2) mature, integrate, and survive for over 1 year in the nude mouse brain
22. Detection of GDNF in cultured and grafted hNT Neurons
23. Acetylcholinesterase expression in NTera 2 human neuronal cells: A model for developmental expression in the nervous system
24. Recovery of motor and sensory evoked potentials after transplantation of hNT neurons in rats with complete spinal cord contusion injury
25. Overexpression of GAP-43 in thalamic projection neurons of transgenic mice does not enable them to regenerate axons through peripheral nerve grafts
26. A receptor is expressed in human neurons derived from teratocarcinoma cell line
27. Long-term integration and neuronal differantiation of human embryonal carcinoma cell (NTera-2) transplanted into the caudoputamen of nude mice
28. NTera 2 cells: A human cell line, which displays characteristics expected of a human committed neuronal progenitor cell
29. Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons
30. Identification of new mutations in the Cu/Zn superoxide dismutase gene of patients with familial amyotrophic lateral sclerosis
31. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
32. GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice
33. Neural transplantation of human neuroteratocarcinoma (hNT) neurons into ischemic rats. A quantitative dose-response analysis of cell survival and behavioral recovery
34. Expression of Rab3A GTPase and other synaptic proteins is induced in differentiated NT2N neurons
35. Genetics of amyotrophic lateral sclerosis
36. Differentially regulated production of platelet-derived growth factor and of transforming growth factor beta by a human teratocarcinoma cell line
37. HNT Neurons delay onset of motor deficit in a model of amyotrophic lateral sclerosis
38. The influence of hNT Neurons on dopaminergic ventral mesencephalic neurons in vitro and in vivo
39. Dopaminergic phenotype of hNT cells in vitro
40. Lithium chloride induces the expression of tyrosine hydroxylase in hNT neurons