Iron deficiency decreases mitochondrial aconitase abundance and citrate concentration without affecting tricarboxylic acid cycle capacity in rat liver

Journal of Nutrition

Volumn 132, Issue 4, 2002, Pages 643-651

  Ross, Kerry L ^a   Eisenstein, Richard S ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Citrate; Iron; Iron regulatory proteins; Mitochondrial aconitase; Rats; Tricarboxylic acid cycle

Indexed keywords

ACONITATE HYDRATASE; CITRIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; IRON DEFICIENCY; IRON METABOLISM; LIVER CELL; MALE; MITOCHONDRION; NONHUMAN; RAT;

ANIMALIA;

EID: 0036215728     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/132.4.643     Document Type: Article

References (50)

1. Toxicity associated with iron overload found in hemochromatosis: Possible mechanism in a rat model
2. Regulation of iron metabolism in eukaryotes
3. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress
4. Combinatorial mRNA regulation: Iron regulatory proteins and iso-iron-responsive elements (Iso-IREs)
5. Iron regulatory proteins and the molecular control of mammalian iron metabolism
6. Direct evidence for mRNA binding and post-transcriptional regulation by Escherichia coli aconitases
7. Bacillus subtilis aconitase is an RNA-binding protein
8. Succinate dehydrogenase b mRNA of Drosophila melanogaster has a functional iron-responsive element in its 5′-untranslated region
9. Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements
10. Identification of a conserved and functional iron-responsive element in the 5′ untranslated region of mammalian mitochondrial aconitase
11. Dietary iron intake rapidly influences iron regulatory proteins, ferritin subunits and mitochondrial aconitase in rat liver
12. Dietary iron intake modulates the activity of iron regulatory proteins and the abundance of ferritin and mitochondrial aconitase in rat liver
13. Iron differentially stimulates translation of mitochondrial aconitase and ferritin mRNAs in mammalian cells. Implications for iron regulatory proteins as regulators of mitochondrial citrate utilization
14. Iron-dependent changes in cellular energy metabolism: Influence on citric acid cycle and oxidative phosphorylation
15. Regulation of the 75-kDa subunit of mitochondrial complex I by iron
16. Increased glucose dependence in resting, iron-deficient rats
17. Glucose turnover and oxidation are increased in the iron-deficient anemic rat
18. Standardization of hemoglobinometry II. The hemoglobincyanide method
19. High-yield preparation of isolated rat liver parenchymal cells: A biochemical and fine structural study
20. Use of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations
21. Iron-responsive element-binding protein. Phosphorylation by protein kinase C
22. Postnatal age and the metabolism of medium- and long-chain fatty acids by isolated hepatocytes from small-for-gestational-age and appropriate-for-gestational-age piglets
23. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
24. Comparison of ketoconazole- and fluconazole-induced hepatotoxicity in a primary culture system of rat hepatocytes
25. A simple method for the isolation and purification of total lipids from animal tissues
26. The quantitative colorimetric determination of triglycerides at 410 nm
27. Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction
28. Characterization of the cellular reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT): Subcellular localization, substrate dependence, and involvement of mitochondrial electron transport in MTT reduction
29. Iron deficiency hyperlipidemia in 18-day-old rat pups: Effects of milk lipids, lipoprotein lipase, and triglyceride synthesis
30. Hyperlipidemia in offspring of iron-deficient rats
31. Regulation of the citric acid cycle in mammalian systems
32. Metabolic control analysis. The effects of high enzyme concentrations
33. The role of equilibria in the regulation of metabolism
34. The effect of testosterone on citrate synthesis and citrate oxidation and a proposed mechanism for regulation of net citrate production in prostate
35. Prolactin specifically regulates citrate oxidation and m-aconitase of rat prostate epithelial cells
36. Suppression of TCA cycle activity in the cardiac muscle cell by hydroperoxide-induced oxidant stress
37. Induction of an increase in mitochondrial matrix enzymes in muscle of iron-deficient rats
38. Perturbation of mitochondrial composition in muscle by iron deficiency. Implications regarding regulation of mitochondrial assembly
39. Mitochondrial aconitase binds to the 3′ untranslated region of the mouse hepatitis virus genome
40. The molecular physiology of citrate
41. Malonyl-CoA, fuel sensing, and insulin resistance
42. Iron uptake mechanisms and their regulation in pathogenic bacteria
43. Citrate-dependent iron transport system in Escherichia coli K-12
44. The aconitase function of iron regulatory protein 1. Genetic studies in yeast implicate its role in iron-mediated redox regulation
45. Iron transport across biologic membranes
46. Isotopomer analysis of citric acid cycle and gluconeogenesis in rat liver. Reversibility of isocitrate dehydrogenase and involvement of ATP-citrate lyase in gluconeogenesis
47. Hepatic glucose production and insulin sensitivity and responsiveness in iron-deficient anemic rats
48. Reciprocal changes of muscle oxidases and liver enzymes with recovery from iron deficiency
49. Lactate is essential for maintenance of euglycemia in iron-deficient rats at rest and during exercise