Supression of TCA cycle activity in the cardiac muscle cell by hydroperoxide-induced oxidant stress

American Journal of Physiology - Cell Physiology

Volumn 270, Issue 6 39-6, 1996, Pages

  Janero, David R ^a   Hreniuk, David ^a  

^a NONE

Author keywords

aconitase; cardiomyocyte; citric acid cycle; energy balance; free radicals; hydrogen peroxide; intermediary metabolism; ischemia reperfusion; Krebs cycle; mitochondria; peroxidation; tricarboxylic acid cycle

Indexed keywords

ACONITATE HYDRATASE; HYDROGEN PEROXIDE; ACETIC ACID DERIVATIVE; ACETYL COENZYME A SYNTHETASE; CARBON DIOXIDE;

ANIMAL CELL; ARTICLE; CATALYSIS; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME INACTIVATION; HEART MUSCLE CELL; NONHUMAN; OXIDATIVE STRESS; PEROXIDATION; PRIORITY JOURNAL; RAT; ANIMAL; CELL CULTURE; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; HEART MUSCLE; METABOLISM; OXIDATION REDUCTION REACTION; SPRAGUE DAWLEY RAT;

ACETATE-COA LIGASE; ACETATES; ACONITATE HYDRATASE; ANIMALS; CARBON DIOXIDE; CELLS, CULTURED; CITRIC ACID CYCLE; HYDROGEN PEROXIDE; MYOCARDIUM; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0029744741     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1996.270.6.c1735     Document Type: Article

References (40)

1. Amarasingham, C. R., and B. D, Davis. Regulation of α-ketoglutarate dehydrogenase formation in Escherichia coli. J. Biol. Chem. 240: 3664-3668, 1965.
2. 2 exposure. Am. J. Physiol. 262 (Lung Cell. Mol. Physiol. 6): L495-L501, 1992.
3. Bindoli, A. Lipid peroxidation in mitochondria. Free Radical Biol. Med. 5: 247-261, 1988.
4. Brown, J. M., M. A. Grosso, G. J. Whitman, A. Banerjee, L. S. Terada, J. E. Repine, and A. H. Harken. Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts. Proc. Natl. Acad. Sci. USA 86: 2516-2520, 1989.
5. Buxton, D. B., F. V. Mody, J. Krivokapich, M. E. Phelps, and H. R. Schelbert. Quantitative assessment of prolonged metabolic abnormalities in reperfused canine myocardium. Circ. Res. 85: 1842-1856, 1992.
6. Buxton, D. B., M. Schwaiger, A. Nguyen, M. E. Phelps, and H. R. Schelbert. Radiolabeled acetate as a tracer of myocardial tricarboxylic acid cycle flux. Circ. Res. 63: 628-634, 1989.
7. Castro, L., M. Rodriguez, and R. Radi. Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide. J. Biol. Chem. 269: 29409-29415, 1994.
8. Cha, S., and R. E. Parks, Jr. Succinic thiokinase. I. Purification of the enzyme from pig heart. J. Biol. Chem. 239: 1961-1967, 1969.
9. Cook, R. A., and B. D. Sanwal. Isocitrate dehydrogenase (NAD specific) from Neurospora crassa. Methods Enzymol. 13: 42-47, 1969.
10. Cooney, G. J., H. Taegtmeyer, and E. A. Newsholme. Tricarboxylic acid cycle flux and enzyme activities in the isolated working rat heart. Biochem. J. 200: 701-703, 1981.
11. Deboer, L. W. V., P. A. Bekx, L. Han, and L. Steinke. Pyruvate enhances recovery of rat hearts after ischemia and reperfusion by preventing free radical generation. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H1571-H1576, 1993.
12. Drapier, J.-C., and J. B. Hibbs, Jr. Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. J. Clin. Invest. 78: 790-797, 1986.
13. Flint, D. H., J. F. Tuminello, and M. H. Emptage. The inactivation of Fe-S cluster containing hydro-lyases by superoxide. J. Biol. Chem. 268: 22369-22376, 1993.
14. Gardner, P. R., and I. Fridovich. Inactivation-reactivation of aconitase in Escherichia coli. J. Biol. Chem. 267: 8757-8763, 1992.
15. Gardner, P. R., I. Ranieri, L. B. Epstein, and C. W. White. Superoxide radical and iron modulate aconitase activity in mammalian cells. J. Biol. Chem. 270: 13399-13405, 1995.
16. Goodwin, G. W., and H. Taegtmeyer. Metabolic recovery of isolated working rat heart after brief global ischemia. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H462-H470, 1994.
17. Hatch, M. D. A simple spectrophotometric assay for fumarate hydratase in crude extracts. Anal. Biochem. 85: 271-275, 1978.
18. Janero, D. R. Oxidative myocardial injury and cardiac-derived experimental systems. In: Biological Oxidation Systems, edited by C. C. Reddy, G. A. Hamilton, and K. M. Madyastha. New York: Academic, 1990, p. 977-998.
19. Janero, D. R, Myocardial ischemia-reperfusion injury and the cardioprotective potential of natural antioxidants. In: Natural Antioxidants in Human Health and Disease, edited by B. Frei. New York: Academic, 1994, p. 411-445.
20. Janero, D. R., and C. Burghardt. Production and release of platelet-activating factor by the injured heart-muscle cell (cardiomyocyte). Res. Commun. Chem. Pathol. Pharmacol. 67: 210-218, 1990.
21. Janero, D. R., C. Burghardt, and D. Feldman. Amphiphile-induced heart muscle-cell (myocyte) injury: effects of intracellular fatty acid overload. J. Cell. Physiol. 137: 1-13, 1988.
22. Janero, D. R., D. Hreniuk, and H. M. Sharif. Hydrogen peroxide-induced oxidative stress to the mammalian heartmuscle cell (cardiomyocyte): lethal peroxidative membrane injury. J. Cell. Physiol. 149: 347-364, 1991.
23. Janero, D. R., D. Hreniuk, and H. M. Sharif. Hydrogen peroxide-induced oxidative stress to the mammalian heartmuscle cell (cardiomyocyte): nonperoxidative purine and pyrimidine nucleotide depletion. J. Cell. Physiol. 155: 494-504, 1993.
24. Janero, D. R., D. Hreniuk, and H. M. Sharif. Hydroperoxide-induced oxidative stress impairs heart muscle cell carbohydrate metabolism. Am. J. Physiol. 266 (Cell Physiol. 35): C179-C188, 1994.
25. Janero, D. R., D. Hreniuk, H. M. Sharif, and K. C. Prout. Hydroperoxide-induced oxidative stress alters pyridine nucleotide metabolism in neonatal heart muscle cells. Am. J. Physiol. 264 (Cell Physiol. 33): C1401-C1410, 1993.
26. Janero, D. R., and C. Yarwood. Oxidative modulation and inactivation of rabbit cardiac adenylate deaminase. Biochem. J. 306: 421-427, 1995.
27. Kanazawa, K. Hepatic dysfunction caused by dietary products of lipid peroxidation. Int. J. Tissue React. 13: 67-78, 1991.
28. Kehrer, J. P. Free radicals as mediators of tissue injury and disease. Crit. Rev. Toxicol. 23: 21-48, 1993.
29. Kitto, G. B. Intra- and extramitochondrial malate dehydrogenases from chicken and tuna heart. Methods Enzymol. 13: 106-116, 1969.
30. Lowenstein, J. M. The tricarboxylic acid cycle. In: Metabolic Pathways, edited by D. M. Greenberg. New York: Academic, 1967, p. 146-270.
31. Rose, I. A., and E. L. O'Connell. Mechanism of aconitase action. I. The hydrogen transfer reaction. J. Biol. Chem. 242: 1870-1879, 1967.
32. Ross, J., D. R. Janero, and D. Hreniuk. Identification and molecular characterization of a high-affinity cardiomyocyte transforming growth factor-β2 receptor. FEBS Lett. 320: 229-234, 1993.
33. Sandhu, G. S., A. C. Burrier, and D. R. Janero. Adenosine deaminase inhibitors attenuate ischemic injury and preserve energy balance in isolated guinea pig heart. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H1249-H1256, 1993.
34. Sluse, F. E., A. J. Meijer, and J. M. Tager. Anion translocators in rat-heart mitochondria. FEBS Lett. 18: 149-153, 1971.
35. Srere, P. A., H. Brazil, and L. Gonen. The citrate condensing enzyme of pigeon breast muscle and moth flight muscle. Acta Chem. Scand. 17: S129-S134, 1963.
36. Srere, P. A., B. Sumegi, and A. D. Sherry. Organizational aspects of the citric acid cycle. Biochem. Soc. Symp. 54: 173-182, 1987.
37. Verniquet, F., J. Gaillard, M. Neuburger, and R. Douce. Rapid inactivation of plant aconitase by hydrogen peroxide. Biochem. J. 276: 643-648, 1991.
38. Warshaw, J. B. Cellular energy metabolism during fetal development. III. Deficient acetyl-CoA synthetase, acetylcarnitine transferase and oxidation of acetate in the fetal bovine heart. Biochim. Biophys. Acta 223: 409-415, 1970.
39. Webster, L. T. Studies of the acetyl coenzyme A synthetase reaction. IV. The requirement for monovalent cations. J. Biol. Chem. 241: 5504-5510, 1966.
40. Weiss, R. G., S. T. Gloth, R. Kalil-Filho, V. P. Chacko, M. D. Stern, and G. Gerstenblith. Indexing tricarboxylic acid cycle flux in intact hearts by carbon-13 nuclear magnetic resonance. Circ. Res. 70: 392-408, 1992.