In vitro and in vivo activities of three acridine thioethers against Leishmania donovani

Pharmacology

Volumn 65, Issue 2, 2002, Pages 74-82

  Mesa, Concepción ^a   Rodriguez Cabezas, Nieves ^b   Castilla, Juan J ^b   Moraleda Lindez, Valentín ^a   Barbe, Jacques ^c   Sanchez Moreno, Manuel ^b   Osuna, Antonio ^b,d  

^a UNIVERSITY OF ALMERÍA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

^c CNRS   (France)

^d Instituto de Biotecnologia   (Spain)

Author keywords

Acridines; In vivo and in vitro action; Leishmania

Indexed keywords

ACRIDINE DERIVATIVE; ANTILEISHMANIAL AGENT; BG 203; BG 237; BG 289; CARBOHYDRATE; NUCLEIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARBOHYDRATE SYNTHESIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG SCREENING; DRUG TARGETING; ENERGY YIELD; ENZYME ACTIVITY; FEMALE; FLAGELLATE; LEISHMANIA DONOVANI; MORPHOLOGICAL TRAIT; NONHUMAN; PARASITE INCIDENCE; PARASITOSIS; PRIORITY JOURNAL; RAT; ULTRASTRUCTURE;

ACETATES; ACRIDINES; ANIMALS; ANTIPROTOZOAL AGENTS; CELL DIVISION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; LACTIC ACID; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; LEUCINE; MACROPHAGES; MICE; MICROSCOPY, ELECTRON; PYRUVATES; RATS; RATS, WISTAR; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; SUCCINIC ACID; THYMIDINE; TIME FACTORS; TRITIUM; URIDINE;

EID: 0036214969     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056190     Document Type: Article

References (34)

1. AIDS leishmaniasis dangers of clash highlighted
2. Sodium stibogluconate in the treatment of Kala-Azar: Report on the treatment of 8 cases and the appearance of probable drug reactions
3. Suppression of Leishmania donovaniby oral administration of a bis(benzyl)polyamine analog
4. Purine analogs as chemotherapeutic agents in leishmaniasis and American trypanosomiasis
5. Activity of antitumour drugs against African trypanosomes
6. In vitro action of platinum (II) and platinum (IV) complexes on Trypanosoma cruzi and Leishmania donovani
7. In vitro action of newly organometallic compounds against trypanosomatidae protozoa
8. Activity of rhodium (III) complexes against Trypanosoma cruzi
9. Adducts of nitroimidazole derivatives with rhodium (II) carboxylates: Syntheses, characterization and evaluation of antichagasic activities
10. In vitro and in vivo activity of new rhodium (III) complexes against Leishmania donovani
11. The activities of four anticancer alkylisophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei
12. Antileishmanial activity of the ether phospholipid ilmofosine
13. In vitro activities of acridone alkaloids against Pneumocystis carinii
14. Structure-activity relationships for the antileishmanial and antitrypanosomal activities of 1′-substituted 9-anilinoacridines
15. 9-Anilinoacridines as potential antileishmanial agents
16. Activity and mode of action of acridine compounds against Leishmania donovani
17. Renal function in patients with mucocutaneous leishmaniasis treated with pentavalent antimonial
18. Cytotoxicity of acridine compounds for Leishmania promastigotes in vitro
19. Cleavable complex formation in Leishmania chagasi treated with anilinoacridines
20. Structure-activity relationships and modes of action of 9-anilinoacridines against chloroquine-resistant Plasmodium falciparum in vitro
21. In vitro study of anticancer acridines as potential antitrypanosomal and antimalarial agents
22. In vitro and in vivo activities of atalaphillinine and related acridone alkaloids against rodent malaria
23. Synthesis and in vitro evaluation of 9-anilino-3,6-diaminoacridines active against a multidrug-resistant strain of the malaria parasite Plasmodium falciparum
24. Synthesis of two novel thioacridinic derivatives and comparison of their in vitro biological activities
25. 'In vitro' action of Pt(II) and Pt(IV) complexes on Trypanosoma cruzi and Leishmania donovani
26. 1H]NMR characterization of its amastigote-like forms
27. Compartimentation of carbohydrate metabolism in trypanosomes
28. Metabolic studies of the protozoan parasite Crithidia luciliae, using proton nuclear magnetic resonance spectroscopy
29. The occurrence of glycosomes (microbodies) in the promastigote stage of four major Leishmania species
30. New antiparasitic agents. III. Comparison between trypanocidal activities of some acridine derivatives against Trypanosoma cruzi 'in vitro'
31. Decanetation of kinetoplast DNA by ATP-dependent DNA topoisomerase from kinetoplast hemoflagellate Leishmania donovani
32. Mechanistic aspects of DNA topoisomerases
33. Acción 'in vivo' de tres derivados benzo(de)isiquinolil-1,3-diona sobre Trypanosoma cruzi