Adjuvant therapy of colon cancer: A review

Clinical Colorectal Cancer

Volumn 1, Issue 4, 2002, Pages 230-236

  Hobday, Timothy J ^a   Erlichman, Charles ^a  

^a MAYO CLINIC   (United States)

Author keywords

5 fluorouracil; Fluorodeoxyuridine; Hepatic arterial infusion; Immunotherapy; Leucovorin; Levamisole; Locoregional chemotherapy; Portal vein infusion

Indexed keywords

5 ETHYNYLURACIL; CAPECITABINE; CARBOPLATIN; CISPLATIN; EDRECOLOMAB; FLOXURIDINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; LEVAMISOLE; METHOTREXATE; MITOMYCIN; MONOCLONAL ANTIBODY; OXALIPLATIN; PREDNISONE; PRODRUG; RALTITREXED; SEMUSTINE; TEGAFUR; URACIL; VINCRISTINE;

CANCER ADJUVANT THERAPY; CANCER IMMUNOTHERAPY; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; COLON CANCER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; HEPATIC ARTERY; HUMAN; MAJOR CLINICAL STUDY; META ANALYSIS; METASTASIS; PORTAL VEIN; PREDICTION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REVIEW; SIDE EFFECT; VALIDATION PROCESS;

EID: 0036214792     PISSN: 15330028     EISSN: None     Source Type: Journal    
DOI: 10.3816/CCC.2002.n.004     Document Type: Review

References (52)

1. Therapy for early-stage colorectal cancer
2. Cancer incidence and mortality, 1973-1995: A report card for the U.S
3. The classification of cancer of the rectum
4. The prognostic significance of direct extension of carcinoma of the colon and rectum
5. Adjuvant postoperative fluorouracil-modulated chemotherapy combined with pelvic radiation therapy for rectal cancer: Initial results of intergroup 0114
6. Adjuvant therapy of colorectal cancer. Why we still don't know
7. Postoperative adjuvant chemotherapy or BCG for colon cancer: Results from NSABP protocol C-01
8. Adjuvant therapy in large bowel adenocarcinoma: Long-term results of a Southwest Oncology Group Study
9. Adjuvant chemotherapy with fluorouracil and CCNU in colon cancer. Results of a multicentric randomized study
10. The benefit of leucovorin-modulated fluorouracil as postoperative as postoperative adjuvant therapy for primary colon cancer: Results from National Surgical Adjuvant Breast and Bowel Project protocol C-03
11. Surgical adjuvant therapy of large-bowel carcinoma: An evaluation of levamisole and the combination of levamisole and fluorouracil. The North Central Cancer Treatment Group and the Mayo Clinic
12. Mechanism of synergy of levamisole and fluorouracil: Induction of human leukocyte antigen class I in a colorectal cancer cell line
13. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma
14. Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: A final report
15. Adjuvant therapy for patients with colon and rectal cancer
16. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project
17. Controlled trial of fluorouracil and low-dose leucovorin given for 6 months as postoperative adjuvant therapy for colon cancer
18. Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. International Multicentre Pooled Analysis of Colon Cancer Trials (IMPACT) investigators
19. Prospective ly randomized trial of postoperative adjuvant chemotherapy in patients with high-risk colon cancer
20. Fluorouracil (FU), leucovorin (LV) and levamisole (LEV) adjuvant therapy for colon cancer: Five-year final report of INT-0089
21. Clinical trial to assess the relative efficacy of fluorouracil and leucovorin, fluorouracil and levamisole, and fluorouracil, leucovorin, and levamisole in patients with Dukes' B and C carcinoma of the colon: Surgical Adjuvant Breast and Bowel Project C-04
22. Intergroup study of fluorouracil plus levamisole as adjuvant therapy for stage II/Dukes' B2 colon cancer
23. Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: Results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
24. Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer. International Multicentre Pooled Analysis of B2 Colon Cancer Trials (IMPACT B2) Investigators
25. Five-year prospective study of DNA tumor ploidy and colorectal cancer survival
26. DNA ploidy and cell kinetic measurements as predictors of recurrence and survival in stages B2 and C colorectal adenocarcinoma
27. Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator
28. The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer
29. Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers
30. A randomized controlled trial of adjuvant portal vein cytotoxic perfusion in colorectal cancer
31. Portal vein chemotherapy for colorectal cancer: A meta-analysis of 4000 patients in 10 studies
32. Adjuvant therapy of Dukes' A, B, and C adenocarcinoma of the colon with portal-vein fluorouracil hepatic infusion: Preliminary results of National Surgical Adjuvant Breast and Bowel Project Protocol C-02
33. Adjuvant portal-vein infusion of fluorouracil and heparin in colorectal cancer: A randomised trial
34. Postoperative radiation therapy for high-risk colon carcinoma
35. A phase III study of adjuvant radiation therapy (RT), 5-fluorouracil (5-FU), and levamisole (LEV) vs 5-FU and LEV in selected patients with resected, high risk colon cancer: Initial results of Int 0130
36. Monoclonal antibody therapy for resected Dukes' C colorectal cancer: Seven-year outcome of a multicenter randomized trial
37. Edrecolomab (PanorexTM, 17-la antibody) (Edre) alone or in combination with 5-FU based chemotherapy in adjuvant treatment of stage III colon cancer: A safety review
38. Adjuvant 5-fluorouracil and leucovorin with or without interferon alfa-2a in colon carcinoma: National Surgical Adjuvant Breast and Bowel Project protocol C-05
39. Combined analysis of two phase III randomized trials comparing irinotecan (C), fluorouracil (F), leucovorin (L) vs F alone as first-line therapy of previously untreated metastatic colorectal cancer (MCRC)
40. Liver resection for colorectal metastases
41. Resection of colorectal liver metastases
42. Hepatic arterial infusion of chemotherapy after resection of hepatic metastases from colorectal cancer
43. The blood supply to neoplasms in the liver
44. Regional versus systemic chemotherapy in the treatment of colorectal carcinoma metastatic to the liver. Is there a survival difference? Meta-analysis of the published literature
45. Short-term hepatic arterial infusion chemotherapy of 5-FU after curative resection of colorectal liver metastases significantly improves disease free survival
46. Results of the Intergroup [Eastern Cooperative Oncology Group (ECOG) and Southwest Oncology Group (SWOG) prospective randomized study of surgery alone versus continuous hepatic artery infusion of FUDR and continuous of 5FU after hepatic resection for colorectal liver metastases
47. Phase II study of hepatic arterial infusion (HAI) plus systemic (SYS) chemotherapy (CH) after multiple metastasectomy in patients (Pts) with colorectal carcinoma metastatic (M-CRC) to the liver: A North Central (NCCTG) study
48. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
49. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
50. Folate-based thymidylate synthase inhibitors as anticancer drugs
51. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer