Interleukin-12 administration is more effective for preventing metastasis than for inhibiting primary established tumors in a murine model of spontaneous hepatic metastasis

Surgery Today

Volumn 32, Issue 3, 2002, Pages 236-242

  Kobayashi, Terutada ^a   Shiiba, Kenichi ^a   Satoh, Masayuki ^a   Hashimoto, Wataru ^b   Mizoi, Takayuki ^a   Matsuno, Seiki ^a   Takeda, Kazuyoshi ^c  

^a Postgraduate School of Medicine   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

Author keywords

Immunotherapy; Interleukin 12; Liver metastasis

Indexed keywords

INTERLEUKIN 12;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CANCER PREVENTION; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; INOCULATION; LIVER METASTASIS; LYMPHOCYTE PROLIFERATION; MALE; METASTASIS INHIBITION; MOUSE; NATURAL KILLER CELL; NONHUMAN; T LYMPHOCYTE; TUMOR GROWTH;

ANIMALS; CYTOTOXICITY, IMMUNOLOGIC; DISEASE MODELS, ANIMAL; INTERLEUKIN-12; LEUKOCYTES, MONONUCLEAR; LIVER NEOPLASMS; LYMPHOMA; MALE; MICE; MICE, INBRED BALB C; NEOPLASM METASTASIS; SPLEEN; T-LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 0036210064     PISSN: 09411291     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005950200027     Document Type: Article

References (26)

1. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes
2. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from B-lymphoblastoid cells
3. Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production
4. Antitumor and antimetastatic activity of interleukin 12 against murine tumors
5. + αβ T cells activated by IL-12 as a major effector in inhibition of experimental tumor metastasis
6. + αβ T cells in the lungs of euthymic and athymic mice
7. Requirement for Vα14 NKT cells in IL-12-mediated rejection of tumors
8. + T cells in IL-12-induced immune responses in vivo
9. IL-12-induced tumor regression correlates with in situ activity of IFN-γ produced by tumor-infiltrating cells and its secondary induction of anti-tumor pathways
10. The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor
11. Administration of recombinant interleukin 12 prevents outgrowth of tumor cells metastasizing spontaneously to lung and lymph nodes
12. Systemic administration of rIL-12 induces complete tumor regression and protective immunity: Response is correlated with a striking reversal of suppressed IFN-γ production by anti-tumor T cells
13. Molecular mechanisms underlying IFN-γ-mediated tumor growth inhibition induced during tumor immunotherapy with rIL-12
14. Enhanced induction of very late antigen 4/lymphocyte function-associated antigen 1-dependent T-cell migration to tumor sites following adminsitration of interleukin 12
15. Multiple roles of interferon-γ in the mediation of interleukin 12-induced tumor regression
16. + αβ T cells with intermediate TCR induced in the liver of mice by IL-12
17. Murine tumor cells metastasizing selectively in the liver: Ability to produce hepatocyte-activating cytokines interleukin-1 and/or -6
18. Enhanced expression of Lipocortin-1 as a new immunosuppressive protein in cancer patients and its influence on reduced in vitro peripheral blood lymphocyte response to mitogens
19. An essential regulatory role for macrophage migration inhibitory factor in T-cell activation
20. + αβ T cells with potent cytotoxicity in the liver of mice via production of IL-12 from Kupffer cells
21. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor)
22. + T lymphocytes, and NK cells
23. Cytotoxic γδ or αβ T cells with a natural killer cell marker, CD56, induced from human peripheral blood lymphocytes by a combination of IL-12 and IL-2
24. + T cells and their IFN-γ production in the generalized Shwartzman reaction
25. + T cells on experimental haematogenous tumour metastases in the liver and lungs of mice
26. Perforin-dependent NK cell cytotoxicity is sufficient for anti-metastatic effect of IL-12