Perfringolysin O expression in Clostridium perfringens is independent of the upstream pfoR gene

Journal of Bacteriology

Volumn 184, Issue 7, 2002, Pages 2034-2038

  Awad, Milena M ^a   Rood, Julian I ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOXIN; GENE PRODUCT; PROTEIN PFOR; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GENE; CLOSTRIDIUM PERFRINGENS; CONTROLLED STUDY; ESCHERICHIA COLI; GAS GANGRENE; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC RECOMBINATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; STRUCTURAL GENE;

BACTERIAL TOXINS; CHROMOSOMES, BACTERIAL; CLOSTRIDIUM PERFRINGENS; GENE DELETION; GENE EXPRESSION; GENES, BACTERIAL; GENETIC COMPLEMENTATION TEST; HEMOLYSIN PROTEINS; TRANS-ACTIVATORS;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM; CLOSTRIDIUM PERFRINGENS; CLOSTRIDIUM PERFRINGENS A; ESCHERICHIA COLI; POSIBACTERIA; PROKARYOTA;

EID: 0036209436     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.184.7.2034-2038.2002     Document Type: Article

References (22)

1. Virulence studies on chromosomal α-toxin and θtoxin mutants constructed by allelic exchange provide genetic evidence for the essential role of α-toxin in Clostridium perfringens-mediated gas gangrene
2. Synergistic effects of alpha-toxin and perfringolysin O in Clostridium perfringens-mediated gas gangrene
3. Isolation of α-toxin, θ-toxin and κ-toxin mutants of Clostridium perfringens by Tn916 mutagenesis
4. Clostridium perfringens-Escherichia coli shuttle vectors that carry single antibiotic resistance determinants
5. Identification of novel VirR/VirS-regulated genes in Clostridium perfringens
6. The virR/virS locus regulates the transcription of genes encoding extracellular toxin production in Clostridium perfringens
7. The VirR response regulator from Clostridium perfringens binds independently to two imperfect direct repeats located upstream of the pfoA promoter
8. Improved detection of helix-turn-helix DNA binding motifs in protein sequences
9. Use of genetically manipulated strains of Clostridium perfringens reveals that both alpha-toxin and theta-toxin are required for vascular leukostasis to occur in experimental gas gangrene
10. Analysis of the SlyA-controlled expression, subcellular localization and pore-forming activity of a 34 kDa haemolysin (ClyA) from Escherichia coli K-12
11. Conjugative transfer of RP4-oriT shuttle vectors from Escherichia coli to Clostridium perfringens
12. Identification and molecular analysis of a locus that regulates extracellular toxin production in Clostridium perfringens
13. Collagenase gene (colA) is located in the 3′-flanking region of the perfringolysin O (pfoA) locus in Clostridium perfringens
14. Genetic analysis of the ycgJ-metB-cysK-ygaG operon negatively regulated by the VirR/VirS system in Clostridium perfringens
15. Virulence genes of Clostridium perfringens
16. Gene cloning shows the alpha toxin of Clostridium perfringens to contain both sphingomyelinase and lecithinase activities
17. Electroporation -mediated transformation of lysostaphin-treated Clostridium perfringens
18. The virR gene, a member of a class of two-component response regulators, regulates the production of perfringolysin O, collagenase, and hemagglutinin in Clostridium perfringens
19. An Upstream regulatory sequence stimulates expression of the perfringolysin O gene of Clostridium perfringens
20. Clostridial gas gangrene: Evidence that α and θ toxins differentially modulate the immune response and induce acute tissue necrosis
21. The thiol-activated clostridial toxins
22. A genetically engineered vaccine against the alpha-toxin of Clostridium perfringens protects against experimental gas gangrene